Search Results - "Delaney, Colin"

Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression by Padeken, Jan, Methot, Stephen, Zeller, Peter, Delaney, Colin E, Kalck, Veronique, Gasser, Susan M

“…The establishment and maintenance of chromatin domains shape the epigenetic memory of a cell, with the methylation of histone H3 lysine 9 (H3K9me) defining…”
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Identification of epigenetically altered genes in sporadic amyotrophic lateral sclerosis by Figueroa-Romero, Claudia, Hur, Junguk, Bender, Diane E, Delaney, Colin E, Cataldo, Michael D, Smith, Andrea L, Yung, Raymond, Ruden, Douglas M, Callaghan, Brian C, Feldman, Eva L

“…Amyotrophic lateral sclerosis (ALS) is a terminal disease involving the progressive degeneration of motor neurons within the motor cortex, brainstem and spinal…”
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Analysis of DNA Methylation by Pyrosequencing by Delaney, Colin, Garg, Sanjay K, Yung, Raymond

“…Pyrosequencing is a technique that uses a sequencing-by-synthesis system which is designed to quantify single-nucleotide polymorphisms (SNPs). Artificial C/T…”
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H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity by Methot, Stephen P., Padeken, Jan, Brancati, Giovanna, Zeller, Peter, Delaney, Colin E., Gaidatzis, Dimos, Kohler, Hubertus, van Oudenaarden, Alexander, Großhans, Helge, Gasser, Susan M.

“…The developmental role of histone H3K9 methylation (H3K9me), which typifies heterochromatin, remains unclear. In Caenorhabditis elegans , loss of H3K9me leads…”
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Heterochromatic foci and transcriptional repression by an unstructured MET-2/SETDB1 co-factor LIN-65 by Delaney, Colin E, Methot, Stephen P, Guidi, Micol, Katic, Iskra, Gasser, Susan M, Padeken, Jan

“…The segregation of the genome into accessible euchromatin and histone H3K9-methylated heterochromatin helps silence repetitive elements and tissue-specific…”
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SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity by Delaney, Colin E., Methot, Stephen P., Kalck, Veronique, Seebacher, Jan, Hess, Daniel, Gasser, Susan M., Padeken, Jan

“…Transcriptionally silenced heterochromatin bearing methylation of histone H3 on lysine 9 (H3K9me) is critical for maintaining organismal viability and tissue…”
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Author Correction: SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity by Delaney, Colin E., Methot, Stephen P., Kalck, Veronique, Seebacher, Jan, Hess, Daniel, Gasser, Susan M., Padeken, Jan

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A histone H4 lysine 20 methyltransferase couples environmental cues to sensory neuron control of developmental plasticity by Delaney, Colin E, Chen, Albert T, Graniel, Jacqueline V, Dumas, Kathleen J, Hu, Patrick J

“…Animals change developmental fates in response to external cues. In the nematode , unfavorable environmental conditions induce a state of diapause known as…”
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Unexpected role for dosage compensation in the control of dauer arrest, insulin-like signaling, and FoxO transcription factor activity in Caenorhabditis elegans by Dumas, Kathleen J, Delaney, Colin E, Flibotte, Stephane, Moerman, Donald G, Csankovszki, Gyorgyi, Hu, Patrick J

“…During embryogenesis, an essential process known as dosage compensation is initiated to equalize gene expression from sex chromosomes. Although much is known…”
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Requirement for translocon-associated protein (TRAP) α in insulin biogenesis by Li, Xin, Itani, Omar A, Haataja, Leena, Dumas, Kathleen J, Yang, Jing, Cha, Jeeyeon, Flibotte, Stephane, Shih, Hung-Jen, Delaney, Colin E, Xu, Jialu, Qi, Ling, Arvan, Peter, Liu, Ming, Hu, Patrick J

“…The mechanistic basis for the biogenesis of peptide hormones and growth factors is poorly understood. Here, we show that the conserved endoplasmic reticulum…”
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Maternal diet supplemented with methyl-donors protects against atherosclerosis in F1 ApoE(-/-) mice by Delaney, Colin, Garg, Sanjay K, Fernandes, Chris, Hoeltzel, Mark, Allen, Robert H, Stabler, Sally, Yung, Raymond

“…Atherosclerosis is an inflammatory condition of the arterial wall mediated by cells of both innate and adaptive immunity. T lymphocytes play an important role…”
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Aging is associated with increased regulatory T‐cell function by Garg, Sanjay K., Delaney, Colin, Toubai, Tomomi, Ghosh, Amiya, Reddy, Pavan, Banerjee, Ruma, Yung, Raymond

“…Summary Regulatory T‐cell (Treg, CD4+CD25+) dysfunction is suspected to play a key role in immune senescence and contributes to increased susceptibility to…”
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Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue by Lumeng, Carey N, Liu, Jianhua, Geletka, Lynn, Delaney, Colin, Delproposto, Jennifer, Desai, Anjali, Oatmen, Kelsie, Martinez-Santibanez, Gabriel, Julius, Annabelle, Garg, Sanjay, Yung, Raymond L

“…Age-related adiposity has been linked to chronic inflammatory diseases in late life. To date, the studies on adipose tissue leukocytes and aging have not taken…”
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Changes in adipose tissue macrophages and T cells during aging by Garg, Sanjay K, Delaney, Colin, Shi, Hang, Yung, Raymond

“…Adipose tissue historically was believed to be an inert tissue, functioning primarily in the storage of energy and thermal homeostasis. However, recent…”
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Diet Influences Expression of Autoimmune‐Associated Genes and Disease Severity by Epigenetic Mechanisms in a Transgenic Mouse Model of Lupus by Strickland, Faith M., Hewagama, Anura, Wu, Ailing, Sawalha, Amr H., Delaney, Colin, Hoeltzel, Mark F., Yung, Raymond, Johnson, Kent, Mickelson, Barbara, Richardson, Bruce C.

“…Objective Lupus flares occur when genetically predisposed individuals encounter appropriate environmental agents. Current evidence indicates that the…”
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Neuropathy Target Esterase Gene Mutations Cause Motor Neuron Disease by Rainier, Shirley, Bui, Melanie, Mark, Erin, Thomas, Donald, Tokarz, Debra, Ming, Lei, Delaney, Colin, Richardson, Rudy J., Albers, James W., Matsunami, Nori, Stevens, Jeff, Coon, Hilary, Leppert, Mark, Fink, John K.

“…The possibility that organophosphorus (OP) compounds contribute to motor neuron disease (MND) is supported by association of paraoxonase 1 polymorphisms with…”
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Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus by Strickland, Faith M, Hewagama, Anura, Lu, Qianjian, Wu, Ailing, Hinderer, Robert, Webb, Ryan, Johnson, Kent, Sawalha, Amr H, Delaney, Colin, Yung, Raymond, Richardson, Bruce C

“…Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease primarily afflicting women. The reason for the gender bias is unclear, but genetic…”
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Maternal methyl-donor supplementation increases regulatory T-cell-mediated redox remodeling (P4422) by Yung, Raymond, Delaney, Colin, Garg, Sanjay, Banerjee, Ruma

“…Regulatory T cells (Treg) maintain peripheral tolerance by inhibiting the proliferation of effector T (Teff) cells. Previously, we exposed dams to a diet…”
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Maternal micronutrient supplementation suppresses T cell chemokine receptor expression and function in F1 mice by Delaney, Colin, Hoeltzel, Mark, Garg, Sanjay K, Warner, Roscoe, Johnson, Kent, Yung, Raymond

“…Prenatal environmental exposures play a critical role in determining late-life chronic disease susceptibility. However, the mechanisms linking the in utero…”
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Changes in adipose tissue macrophage and T cell during aging by Garg, Sanjay K, Delaney, Colin, Shi, Hang, Yung, Raymond

“…Adipose tissue historically was believed to be an inert tissue, functioning primarily in the storage of energy and thermal homeostasis. However, recent…”
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