Search Results - "Delalande, Clémence"

Inhibitors of DHHC family proteins by Lan, Tong, Delalande, Clémence, Dickinson, Bryan C.

“…Protein S-acylation is a prevalent post-translational protein lipidation that is dynamically regulated by ‘writer’ protein S-acyltransferases and ‘eraser’…”
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Molecular Glue Discovery: Current and Future Approaches by Dewey, Jeffrey A., Delalande, Clémence, Azizi, Saara-Anne, Lu, Vivian, Antonopoulos, Dionysios, Babnigg, Gyorgy

“…The intracellular interactions of biomolecules can be maneuvered to redirect signaling, reprogram the cell cycle, or decrease infectivity using only a few…”
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Development of an Acrylamide-Based Inhibitor of Protein S‑Acylation by Azizi, Saara-Anne, Lan, Tong, Delalande, Clémence, Kathayat, Rahul S, Banales Mejia, Fernando, Qin, Alice, Brookes, Noah, Sandoval, Perla Jasmine, Dickinson, Bryan C

“…Protein S-acylation is a dynamic lipid post-translational modification that can modulate the localization and activity of target proteins. In humans, the…”
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Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20 by Azizi, Saara-Anne, Delalande, Clémence, Lan, Tong, Qiu, Tian, Dickinson, Bryan C.

“…Protein S-acylation is a dynamic and reversible lipid post-translational modification that can affect the activity, stability, localization, and interactions…”
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Identification of potent and selective small molecule inhibitors of the cation channel TRPM4 by Ozhathil, Lijo Cherian, Delalande, Clémence, Bianchi, Beatrice, Nemeth, Gabor, Kappel, Sven, Thomet, Urs, Ross‐Kaschitza, Daniela, Simonin, Céline, Rubin, Matthias, Gertsch, Jürg, Lochner, Martin, Peinelt, Christine, Reymond, Jean‐Louis, Abriel, Hugues

“…Background and Purpose TRPM4 is a calcium‐activated non‐selective cation channel expressed in many tissues and implicated in several diseases, and has not yet…”
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Metal-free 5-exo-dig cyclization of propargyl urea using TBAF by Huguenot, Florent, Delalande, Clémence, Vidal, Michel

“…We present the first results of the intramolecular cyclization of propargyl ureas catalyzed by TBAF. Depending on the substituents close to the triple bond,…”
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Improved fluorescence assays to measure the defects associated with F508del‐CFTR allow identification of new active compounds by Langron, Emily, Simone, Michela I, Delalande, Clémence M S, Reymond, Jean‐Louis, Selwood, David L, Vergani, Paola

“…Background and Purpose Cystic fibrosis (CF) is a debilitating disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR)…”
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Optimizing TRPM4 inhibitors in the MHFP6 chemical space by Delalande, Clémence, Awale, Mahendra, Rubin, Matthias, Probst, Daniel, Ozhathil, Lijo C., Gertsch, Jürg, Abriel, Hugues, Reymond, Jean-Louis

“…We recently reported 4-chloro-2-(2-chlorophenoxy)acetamido)benzoic acid (CBA) as the first potent inhibitor of TRPM4, a cation channel implicated in cardiac…”
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Frontiers in Medicinal Chemistry 2017 in Bern, Switzerland by Probst, Daniel, Heitz, Marc, Poirier, Marion, Gan, Bee Ha, Delalande, Clémence, Reymond, Jean‐Louis

“…Sharing capital ideas: The 2017 Frontiers in Medicinal Chemistry (FiMC) conference, organized jointly by the German Chemical Society, the German Pharmaceutical…”
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Investigation of TRPM4 in Prostate Cancer Cells with Novel Small Molecule Inhibitors by Borgström, Anna, Hauert, Barbara, Kappel, Sven, Delalande, Clémence, Reymond, Jean-Louis, Peinelt, Christine

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