Search Results - "Delaissé, J M"

The Type I Collagen Fragments ICTP and CTX Reveal Distinct Enzymatic Pathways of Bone Collagen Degradation by Garnero, P, Ferreras, M, Karsdal, MA, Nicamhlaoibh, R, Risteli, J, Borel, O, Qvist, P, Delmas, PD, Foged, NT, Delaissé, JM

“…Bone resorption may generate collagen fragments such as ICTP and CTX, which can be quantified in serum and/or urine by using specific immunoassays, and which…”
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The Bone Lining Cell: Its Role in Cleaning Howship's Lacunae and Initiating Bone Formation by Everts, V., Delaissé, J. M., Korper, W., Jansen, D. C., Tigchelaar‐Gutter, W., Saftig, P., Beertsen, W.

“…In this study we investigated the role of bone lining cells in the coordination of bone resorption and formation. Ultrastructural analysis of mouse long bones…”
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Osteoclast nuclei of myeloma patients show chromosome translocations specific for the myeloma cell clone: a new type of cancer-host partnership? by Andersen, TL, Boissy, P, Sondergaard, TE, Kupisiewicz, K, Plesner, T, Rasmussen, T, Haaber, J, Kølvraa, S, Delaissé, J-M

“…A major clinical manifestation of bone cancers is bone destruction. It is widely accepted that this destruction is not caused by the malignant cells…”
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Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases by BOISSIER, S, FERRERAS, M, PEYRUCHAUD, O, MAGNETTO, S, EBETINO, F. H, COLOMBEL, M, DELMAS, P, DELAISSE, J.-M, CLEZARDIN, P

“…The molecular mechanisms by which tumor cells metastasize to bone are likely to involve invasion, cell adhesion to bone, and the release of soluble mediators…”
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Biochemical markers of type II collagen breakdown and synthesis are positioned at specific sites in human osteoarthritic knee cartilage by Bay-Jensen, A.-C., M.Sc, Andersen, T.L., M.Sc, Charni-Ben Tabassi, N., Ph.D, Kristensen, P.W., M.D, Kjaersgaard-Andersen, P., M.D, Sandell, L., Ph.D, Garnero, P., Ph.D, Delaissé, J.-M., Ph.D

“…Summary Objective To investigate whether type II collagen turnover markers used for osteoarthritis (OA) activity evaluation in body fluids can be detected at…”
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Matrix Metalloproteinase 9 and Vascular Endothelial Growth Factor Are Essential for Osteoclast Recruitment into Developing Long Bones by Engsig, Michael T., Chen, Qing-Jun, Vu, Thiennu H., Pedersen, Anne-Cecilie, Therkidsen, Bente, Lund, Leif R., Henriksen, Kim, Lenhard, Thomas, Foged, Niels T., Werb, Zena, Delaisse, Jean-Marie

“…Bone development requires the recruitment of osteoclast precursors from surrounding mesenchyme, thereby allowing the key events of bone growth such as marrow…”
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Pulse treatment with the proteasome inhibitor bortezomib inhibits osteoclast resorptive activity in clinically relevant conditions by Boissy, P, Andersen, T.L, Lund, T, Kupisiewicz, K, Plesner, T, Delaissé, J.M

“…Abstract Myeloma bone disease is due to bone degradation by osteoclasts, and absence of repair by bone forming osteoblasts. Recent observations suggest that…”
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Endothelial cell-driven regulation of CD9 or motility-related protein-1 expression in multiple myeloma cells within the murine 5T33MM model and myeloma patients by DE BRUYNE, E, ANDERSEN, T. L, DE RAEVE, H, VAN VAICKENBORGH, E, CAERS, J, VAN CAMP, B, DELAISSE, J.-M, VAN RIET, I, VANDERKERKEN, K

“…The cell surface expression of CD9, a glycoprotein of the tetraspanin family influencing several processes including cell motility and metastasis, inversely…”
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The type II collagen fragments Helix-II and CTX-II reveal different enzymatic pathways of human cartilage collagen degradation by Charni-Ben Tabassi, N., Ph.D, Desmarais, S., Ph.D, Bay-Jensen, A.-C, Delaissé, J.M., Ph.D, Percival, M.D., Ph.D, Garnero, P., Ph.D., D.Sc

“…Summary Objective Cartilage degradation in osteoarthritis (OA) generates the type II collagen fragments, Helix-II and CTX-II that can be used as clinical…”
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Matrix metalloproteinases are obligatory for the migration of preosteoclasts to the developing marrow cavity of primitive long bones by Blavier, L, Delaissé, J M

“…A key event in bone resorption is the recruitment of osteoclasts to future resorption sites. We follow here the migration of preosteoclasts from the periosteum…”
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Cysteine Proteinases and Matrix Metalloproteinases Play Distinct Roles in the Subosteoclastic Resorption Zone by Everts, Vincent, Delaissé, Jean‐Marie, Korper, Wolf, Beertsen, Wouter

“…Digestion of calvarial bone by osteoclasts depends on the activity of cysteine proteinases and matrix metalloproteinases (MMPs). It is unknown, however,…”
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The Migration of Purified Osteoclasts Through Collagen Is Inhibited by Matrix Metalloproteinase Inhibitors by Sato, Takuya, Foged, Niels Tækker, Delaissé, Jean‐Marie

“…The most obvious proteolytic event controlled by the osteoclast is bone matrix removal in the resorption compartment. Here, however, we investigated whether…”
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(Pro)collagenase (matrix metalloproteinase-1) is present in rodent osteoclasts and in the underlying bone-resorbing compartment by DELAISSE, J. M, EECKHOUT, Y, NEFF, L, FRANCOIS-GILLET, C, HENRIET, P, SU, Y, VAES, G, BARON, R

“…Osteoclasts resorb the extracellular matrix of bone by secreting enzymes and acid into a sealed-off compartment that they form upon attachment to the bone…”
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Collagenolytic cysteine proteinases of bone tissue. Cathepsin B, (pro)cathepsin L and a cathepsin L-like 70 kDa proteinase by Delaissé, J M, Ledent, P, Vaes, G

“…The aim of the work was to identify and characterize the cysteine proteinases of bone tissue, as these enzymes appear necessary for bone resorption. Three…”
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Recruitment of osteoblasts in human cancellous bone remodelling by Kristensen, H.B, Andersensen, T.L, Delaissé, J.-M

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Quantification of the collagenolytic activity of isolated osteoclasts by enzyme‐linked immunosorbent assay by Foged, Niels Taekker, Delaisse, Jean‐Marie, Hou, Peng, Lou, Henriette, Sato, Takuya, Winding, Bent, Bonde, Martin

“…Difficulties in the geometrical definition and measurement of resorption pits is a major problem for the quantitative analysis of bone resorption by isolated…”
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Proteinases in bone resorption: obvious and less obvious roles by Delaissé, Jean-Marie, Engsig, Michael T, Everts, Vincent, del Carmen Ovejero, Maria, Ferreras, Mercedes, Lund, Leif, Vu, Thiennu H, Werb, Zena, Winding, Bent, Lochter, André, Karsdal, Morten A, Troen, Tine, Kirkegaard, Tove, Lenhard, Thomas, Heegaard, Anne-Marie, Neff, Lynn, Baron, Roland, Foged, Niels T

“…Bone resorption is critical for the development and the maintenance of the skeleton, and improper regulation of bone resorption leads to pathological…”
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Measurement of tumor load and distribution in a model of cancer-induced osteolysis: a necessary precaution when testing novel anti-resorptive therapies by Amhlaoibh, R Nic, Hoegh-Andersen, P, Brünner, N, Sørensen, A, Winding, B, Holst-Hansen, C, Karsdal, M A, Engsig, M T, Delaissé, J M, Heegaard, A M

“…The Arguello model of cancer metastasis to bone has been used extensively to study breast cancer-induced osteolytic disease. The effects of therapy on skeletal…”
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Capillaries prevail at bone remodelling sites in adult human bone by Kristensen, H.B, Andersen, T.L, Marcussen, N, Rolighed, L, Delaissé, J.-M

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The Collagenolytic Activity of Cathepsin K Is Unique among Mammalian Proteinases by Garnero, Patrick, Borel, Olivier, Byrjalsen, Inger, Ferreras, Mercedes, Drake, Fred H., McQueney, Michael S., Foged, Niels T., Delmas, Pierre D., Delaissé, Jean-Marie

“…Type I collagen fibers account for 90% of the organic matrix of bone. The degradation of this collagen is a major event during bone resorption, but its…”
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