Search Results - "Delahaye, Fabien"

T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling by Chin, Shu Shien, Guillen, Erik, Chorro, Laurent, Achar, Sooraj, Ng, Karina, Oberle, Susanne, Alfei, Francesca, Zehn, Dietmar, Altan-Bonnet, Grégoire, Delahaye, Fabien, Lauvau, Grégoire

“…Cognate antigen signal controls CD8 + T cell priming, expansion size and effector versus memory cell fates, but it is not known if and how it modulates the…”
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Genetic variants influence on the placenta regulatory landscape by Delahaye, Fabien, Do, Catherine, Kong, Yu, Ashkar, Remi, Salas, Martha, Tycko, Ben, Wapner, Ronald, Hughes, Francine

“…From genomic association studies, quantitative trait loci analysis, and epigenomic mapping, it is evident that significant efforts are necessary to define…”
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Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice by Mao, Kai, Quipildor, Gabriela Farias, Tabrizian, Tahmineh, Novaj, Ardijana, Guan, Fangxia, Walters, Ryan O., Delahaye, Fabien, Hubbard, Gene B., Ikeno, Yuji, Ejima, Keisuke, Li, Peng, Allison, David B., Salimi-Moosavi, Hossein, Beltran, Pedro J., Cohen, Pinchas, Barzilai, Nir, Huffman, Derek M.

“…Diminished growth factor signaling improves longevity in laboratory models, while a reduction in the somatotropic axis is favorably linked to human aging and…”
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Maternal Perinatal Undernutrition Drastically Reduces Postnatal Leptin Surge and Affects the Development of Arcuate Nucleus Proopiomelanocortin Neurons in Neonatal Male Rat Pups by Delahaye, Fabien, Breton, Christophe, Risold, Pierre-Yves, Enache, Mihaela, Dutriez-Casteloot, Isabelle, Laborie, Christine, Lesage, Jean, Vieau, Didier

“…A growing body of evidence suggests that maternal undernutrition sensitizes the offspring to the development of energy balance metabolic disorders such as type…”
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Cytolytic circumsporozoite-specific memory CD4+ T cell clones are expanded during Plasmodium falciparum infection by Furtado, Raquel, Paul, Mahinder, Zhang, Jinghang, Sung, Joowhan, Karell, Paul, Kim, Ryung S., Caillat-Zucman, Sophie, Liang, Li, Felgner, Philip, Bauleni, Andy, Gama, Syze, Buchwald, Andrea, Taylor, Terrie, Seydel, Karl, Laufer, Miriam, Delahaye, Fabien, Daily, Johanna P., Lauvau, Grégoire

“…Clinical immunity against Plasmodium falciparum infection develops in residents of malaria endemic regions, manifesting in reduced clinical symptoms during…”
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Epigenetic and Transcriptomic Programming of HSC Quiescence Signaling in Large for Gestational Age Neonates by Pelletier, Alexandre, Carrier, Arnaud, Zhao, Yongmei, Canouil, Mickaël, Derhourhi, Mehdi, Durand, Emmanuelle, Berberian-Ferrato, Lionel, Greally, John, Hughes, Francine, Froguel, Philippe, Bonnefond, Amélie, Delahaye, Fabien

“…Excessive fetal growth is associated with DNA methylation alterations in human hematopoietic stem and progenitor cells (HSPC), but their functional impact…”
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Prenatal Hyperglycemia Exposure and Cellular Stress, a Sugar-Coated View of Early Programming of Metabolic Diseases by Tozour, Jessica, Hughes, Francine, Carrier, Arnaud, Vieau, Didier, Delahaye, Fabien

“…Worldwide, the number of people with diabetes has quadrupled since 1980 reaching 422 million in 2014 (World Health Organization). This distressing rise in…”
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Multi-Omics Data Integration Reveals Sex-Dependent Hippocampal Programming by Maternal High-Fat Diet during Lactation in Adult Mouse Offspring by Gauvrit, Thibaut, Benderradji, Hamza, Pelletier, Alexandre, Aboulouard, Soulaimane, Faivre, Emilie, Carvalho, Kévin, Deleau, Aude, Vallez, Emmanuelle, Launay, Agathe, Bogdanova, Anna, Besegher, Mélanie, Le Gras, Stéphanie, Tailleux, Anne, Salzet, Michel, Buée, Luc, Delahaye, Fabien, Blum, David, Vieau, Didier

“…Early-life exposure to high-fat diets (HF) can program metabolic and cognitive alterations in adult offspring. Although the hippocampus plays a crucial role in…”
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Correction: Genetic variants influence on the placenta regulatory landscape by Delahaye, Fabien, Do, Catherine, Kong, Yu, Ashkar, Remi, Salas, Martha, Tycko, Ben, Wapner, Ronald, Hughes, Francine

“…[This corrects the article DOI: 10.1371/journal.pgen.1007785.]…”
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The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects by Lambert, Erwan, Saha, Orthis, Soares Landeira, Bruna, Melo de Farias, Ana Raquel, Hermant, Xavier, Carrier, Arnaud, Pelletier, Alexandre, Gadaut, Johanna, Davoine, Lindsay, Dupont, Cloé, Amouyel, Philippe, Bonnefond, Amélie, Lafont, Frank, Abdelfettah, Farida, Verstreken, Patrik, Chapuis, Julien, Barois, Nicolas, Delahaye, Fabien, Dermaut, Bart, Lambert, Jean-Charles, Costa, Marcos R, Dourlen, Pierre

“…The Bridging Integrator 1 (BIN1) gene is a major susceptibility gene for Alzheimer's disease (AD). Deciphering its pathophysiological role is challenging due…”
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Maternal prenatal undernutrition programs adipose tissue gene expression in adult male rat offspring under high-fat diet by Lukaszewski, Marie-Amélie, Mayeur, Sylvain, Fajardy, Isabelle, Delahaye, Fabien, Dutriez-Casteloot, Isabelle, Montel, Valérie, Dickes-Coopman, Anne, Laborie, Christine, Lesage, Jean, Vieau, Didier, Breton, Christophe

“…Several studies have shown that maternal undernutrition leading to low birth weight predisposes offspring to the development of metabolic pathologies such as…”
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Maternal prenatal undernutrition alters the response of POMC neurons to energy status variation in adult male rat offspring by Breton, Christophe, Lukaszewski, Marie-Amélie, Risold, Pierre-Yves, Enache, Mihaela, Guillemot, Johann, Rivière, Guillaume, Delahaye, Fabien, Lesage, Jean, Dutriez-Casteloot, Isabelle, Laborie, Christine, Vieau, Didier

“…Epidemiological studies suggest that maternal undernutrition predisposes the offspring to development of energy balance metabolic pathologies in adulthood…”
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Amyloid-Beta Peptides Trigger Premature Functional and Gene Expression Alterations in Human-Induced Neurons by Melo de Farias, Ana Raquel, Pelletier, Alexandre, Iohan, Lukas Cruz Carvalho, Saha, Orthis, Bonnefond, Amélie, Amouyel, Philippe, Delahaye, Fabien, Lambert, Jean-Charles, Costa, Marcos R

“…Alzheimer’s disease (AD) is the most prevalent cause of dementia in the elderly, characterized by the presence of amyloid-beta (Aβ) plaques, neurofibrillary…”
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991 Effects of SAR443579, a trifunctional anti-CD123 NK cell engager (NKCE), on natural killer (NK) cell subsets at the single cell level by Boldina, Galina, Nunes, Manoel, Berthelot, Karine, Dos-Santos-Bele, Wilson, Delahaye, Fabien, Augé, Franck, Biancotto, Angelique, Hadjipanayis, Angela, Cesaroni, Matteo, Virone-Oddos, Angela, Jackson, Donald

“…BackgroundIn Humans, circulating Natural Killer (NK) cytotoxic lymphocytes are represented by distinct subsets, differing in cytokine production, cytotoxicity…”
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Sex-dependent placental methylation quantitative trait loci provide insight into the prenatal origins of childhood onset traits and conditions by Casazza, William, Inkster, Amy M., Del Gobbo, Giulia F., Yuan, Victor, Delahaye, Fabien, Marsit, Carmen, Park, Yongjin P., Robinson, Wendy P., Mostafavi, Sara, Dennis, Jessica K.

“…Molecular quantitative trait loci (QTLs) allow us to understand the biology captured in genome-wide association studies (GWASs). The placenta regulates fetal…”
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Is the adipose tissue a key target of developmental programming of adult adiposity by maternal undernutrition? by Lukaszewski, Marie-Amélie, Delahaye, Fabien, Vieau, Didier, Breton, Christophe

“…Epidemiological studies have shown that maternal undernutrition during pregnancy (MU) leads to intrauterine growth retardation and low birth weight, and may…”
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DNA methylation loci in placenta associated with birthweight and expression of genes relevant for early development and adult diseases by Tekola-Ayele, Fasil, Zeng, Xuehuo, Ouidir, Marion, Workalemahu, Tsegaselassie, Zhang, Cuilin, Delahaye, Fabien, Wapner, Ronald

“…Abstract Background Birthweight marks an important milestone of health across the lifespan, including cardiometabolic disease risk in later life. The placenta,…”
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A road map of memory CD8+ T cell functional imprinting and fitness by Chin, Shu Shien, Chorro, Laurent, Achar, Sooraj, Zehn, Dietmar, Altan-Bonnet, Grergoire, Delahaye, Fabien, Lauvau, Gregoire

“…Abstract Previous studies established that TCR signaling strength determines the size of CD8+ T cell expansion and memory pool. Here we hypothesized that TCR…”
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Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome by Canouil, Mickaël, Khamis, Amna, Keikkala, Elina, Hummel, Sandra, Lobbens, Stephane, Bonnefond, Amélie, Delahaye, Fabien, Tzala, Evangelia, Mustaniemi, Sanna, Vääräsmäki, Marja, Jarvelin, Marjo-Riitta, Sebert, Sylvain, Kajantie, Eero, Froguel, Philippe, Andrew, Toby

“…Gestational diabetes mellitus (GDM) is associated with an increased risk of obesity and insulin resistance in offspring later in life, which might be explained…”
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Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes by Pervjakova, Natalia, Moen, Gunn-Helen, Borges, Maria-Carolina, Ferreira, Teresa, Cook, James P, Allard, Catherine, Beaumont, Robin N, Canouil, Mickaël, Hatem, Gad, Heiskala, Anni, Joensuu, Anni, Karhunen, Ville, Kwak, Soo Heon, Lin, Frederick T J, Liu, Jun, Rifas-Shiman, Sheryl, Tam, Claudia H, Tam, Wing Hung, Thorleifsson, Gudmar, Andrew, Toby, Auvinen, Juha, Bhowmik, Bishwajit, Bonnefond, Amélie, Delahaye, Fabien, Demirkan, Ayse, Froguel, Philippe, Haller-Kikkatalo, Kadri, Hardardottir, Hildur, Hummel, Sandra, Hussain, Akhtar, Kajantie, Eero, Keikkala, Elina, Khamis, Amna, Lahti, Jari, Lekva, Tove, Mustaniemi, Sanna, Sommer, Christine, Tagoma, Aili, Tzala, Evangelia, Uibo, Raivo, Vääräsmäki, Marja, Villa, Pia M, Birkeland, Kåre I, Bouchard, Luigi, Duijn, Cornelia M, Finer, Sarah, Groop, Leif, Hämäläinen, Esa, Hayes, Geoffrey M, Hitman, Graham A, Jang, Hak C, Järvelin, Marjo-Riitta, Jenum, Anne Karen, Laivuori, Hannele, Ma, Ronald C, Melander, Olle, Oken, Emily, Park, Kyong Soo, Perron, Patrice, Prasad, Rashmi B, Qvigstad, Elisabeth, Sebert, Sylvain, Stefansson, Kari, Steinthorsdottir, Valgerdur, Tuomi, Tiinamaija, Hivert, Marie-France, Franks, Paul W, McCarthy, Mark I, Lindgren, Cecilia M, Freathy, Rachel M, Lawlor, Deborah A, Morris, Andrew P, Mägi, Reedik

“…Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy complications and adverse perinatal outcomes. GDM often reoccurs and is…”
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