IGF -I plasma concentrations in non-treated horses and horses administered with methionyl equine somatotropin

IGF -I plasma concentrations in non-treated horses and horses administered with methionyl equine somatotropin

Insulin-like growth factor-I (IGF -I) is likely to be an indicator of somatotropin (ST) administration in the horse. To investigate the different ways ST administration may be detected, the following aspects of IGF -I concentrations in plasma were studied: (i) the daily variation; (ii) variation fol...

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Bibliographic Details
Published in:Research in veterinary science Vol. 71; no. 3; pp. 167 - 173
Main Authors: Popot, M.A., Bobin, S., Bonnaire, Y., Delahaut, P.H., Closset, J.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-12-2001
Subjects:
Age Factors
Animals
Biomarkers - analysis
Circadian Rhythm - physiology
Doping in Sports
Exercise Test - veterinary
Female
Growth Hormone - administration & dosage
Growth Hormone - blood
Horses - blood
Insulin-Like Growth Factor I - analysis
Insulin-Like Growth Factor I - metabolism
Jugular Veins
Male
Physical Conditioning, Animal - physiology
Reference Values
Rest - physiology
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Summary:Insulin-like growth factor-I (IGF -I) is likely to be an indicator of somatotropin (ST) administration in the horse. To investigate the different ways ST administration may be detected, the following aspects of IGF -I concentrations in plasma were studied: (i) the daily variation; (ii) variation following a treadmill test; (iii) concentrations at rest and after exercise; and (iv) concentrations in plasma from two young horses and two adults treated with methionyl equine somatotropin (e ST). In the population of horses at rest, IGF -I mean concentration (SEM) was 261 (104) ng ml−1. In post race samples, IGF -I mean concentration was 187 (100) ng ml−1. All of these data indicate that exercise does not modify IGF -I concentration in plasma. The magnitude of the increase in IGF -I following administration of e ST differed according to the age of the horses. The critical value of 700ng ml−1was exceeded for 1 day in adult horses and for at least 11 days in young horses. These results show that IGF -I has potential as an indirect marker of ST administration in horses.
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ISSN:0034-5288
1532-2661
DOI:10.1053/rvsc.2001.0505