Search Results - "DelaRosa, Olga"
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Modulation of Adult Mesenchymal Stem Cells Activity by Toll-Like Receptors: Implications on Therapeutic Potential
Published in Mediators of Inflammation (01-01-2010)“…Mesenchymal stem cells (MSCs) are of special interest as therapeutic agents in the settings of both chronic inflammatory and autoimmune diseases. Toll-like…”
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Mesenchymal stem cells as a therapeutic tool to treat sepsis
Published in World journal of stem cells (26-03-2015)“…Sepsis is a clinical syndrome caused by a deregulatedhost response to an infection. Sepsis is the mostfrequent cause of death in hospitalized patients.Although…”
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Dissecting Allo-Sensitization After Local Administration of Human Allogeneic Adipose Mesenchymal Stem Cells in Perianal Fistulas of Crohn's Disease Patients
Published in Frontiers in immunology (14-06-2019)“…Adipose mesenchymal stem cells (ASC) are considered minimally immunogenic. This is due to the low expression of human leukocyte antigens I (HLA-I), lack of…”
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Toll-like receptor-mediated signaling in human adipose-derived stem cells: implications for immunogenicity and immunosuppressive potential
Published in Tissue engineering. Part A (01-07-2009)“…Human adipose-derived stem cells (hASCs) are mesenchymal stem cells with reduced immunogenicity and the capability to modulate immune responses. These…”
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Comparative Analysis between the In Vivo Biodistribution and Therapeutic Efficacy of Adipose-Derived Mesenchymal Stromal Cells Administered Intraperitoneally in Experimental Colitis
Published in International journal of molecular sciences (23-06-2018)“…Mesenchymal stem cells (MSCs) have emerged as a promising treatment for inflammatory diseases. The immunomodulatory effect of MSCs takes place both by direct…”
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Human cardiac stem cells inhibit lymphocyte proliferation through paracrine mechanisms that correlate with indoleamine 2,3-dioxygenase induction and activity
Published in Stem cell research & therapy (25-10-2018)“…Transplantation of allogeneic human cardiac/stem progenitor cells (hCSCs) is currently being tested in several phase I/II clinical trials as a novel and…”
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Intralymphatic Administration of Adipose Mesenchymal Stem Cells Reduces the Severity of Collagen-Induced Experimental Arthritis
Published in Frontiers in immunology (21-04-2017)“…Mesenchymal stem cells (MSCs) are multipotent stromal cells with immunomodulatory properties. They have emerged as a very promising treatment for autoimmunity…”
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Human Cardiac-Derived Stem/Progenitor Cells Fine-Tune Monocyte-Derived Descendants Activities toward Cardiac Repair
Published in Frontiers in immunology (26-10-2017)“…Cardiac repair following MI relies on a finely regulated immune response involving sequential recruitment of monocytes to the injured tissue. Monocyte-derived…”
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Biodistribution and Efficacy of Human Adipose-Derived Mesenchymal Stem Cells Following Intranodal Administration in Experimental Colitis
Published in Frontiers in immunology (08-06-2017)“…Mesenchymal stem cells (MSCs) have a large potential in cell therapy for treatment of inflammatory and autoimmune diseases, thanks to their immunomodulatory…”
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Adipose‐derived mesenchymal stromal cells modulate experimental autoimmune arthritis by inducing an early regulatory innate cell signature
Published in Immunity, Inflammation and Disease (01-06-2016)“…Modulation of innate immune responses in rheumatoid arthritis and other immune‐mediated disorders is of critical importance in the clinic since a growing body…”
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Correlation of effector function with phenotype and cell division after in vitro differentiation of naive MART-1-specific CD8+ T cells
Published in International immunology (01-01-2009)“…Adoptive transfer of antigen-specific CD8+ T cells may represent an effective strategy for immunotherapy of tumors such as melanoma, but is limited by the…”
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Toll-like receptors as modulators of mesenchymal stem cells
Published in Frontiers in immunology (01-01-2012)“…Mesenchymal stem cells (MSCs) have differentiation and immunomodulatory properties that make them interesting tools for the treatment of degenerative…”
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Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors
Published in Immunity & ageing (28-08-2009)“…Ageing is associated with changes in the immune system with substantial alterations in T-lymphocyte subsets. Cytomegalovirus (CMV) is one of the factors that…”
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Human Adipose‐Derived Mesenchymal Stem Cells Modulate Experimental Autoimmune Arthritis by Modifying Early Adaptive T Cell Responses
Published in Stem cells (Dayton, Ohio) (01-12-2015)“…Mesenchymal stem cells (MSCs) are multipotent stromal cells with immunosuppressive properties. They have emerged as a very promising treatment for autoimmunity…”
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Safety and Efficacy of Intracoronary Infusion of Allogeneic Human Cardiac Stem Cells in Patients with ST-segment Elevation Myocardial Infarction and Left Ventricular Dysfunction: A Multicenter Randomized, Double-Blind and Placebo-Controlled Clinical Trial
Published in Circulation research (17-08-2018)“…RATIONALE:Allogeneic cardiac stem cells (AlloCSC-01) have shown protective, immunoregulatory and regenerative properties with a robust safety profile in large…”
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Mesenchymal stem cells as therapeutic agents of inflammatory and autoimmune diseases
Published in Current opinion in biotechnology (01-12-2012)“…Graphical abstract Highlights ► Immunomodulatory properties of MSCs in vitro and in vivo are discussed. ► Safety and efficacy of treatments with allogeneic…”
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Requirement of IFN-gamma-mediated indoleamine 2,3-dioxygenase expression in the modulation of lymphocyte proliferation by human adipose-derived stem cells
Published in Tissue engineering. Part A (01-10-2009)“…Human adipose-derived mesenchymal stem cells (hASCs) are mesenchymal stem cells (MSCs) with reduced immunogenicity and capability to modulate immune responses…”
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Human adipose-derived stem cells impair natural killer cell function and exhibit low susceptibility to natural killer-mediated lysis
Published in Stem cells and development (20-05-2012)“…Human adipose-derived stem cells (hASCs) have been successfully used in treating numerous diseases. However, several aspects need to be considered,…”
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Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting: Lessons Learned from First Clinical Trials
Published in Transplantation (15-08-2013)“…The Fourth Expert Meeting of the Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Consortium took place in Barcelona on October 19 and 20, 2012…”
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Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity
Published in Biogerontology (Dordrecht) (01-10-2006)“…Scientific and clinical advances in the last century have led to increased numbers of individuals living to older ages. Thus a major concern is how to live…”
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