Search Results - "Dela Justina, Vanessa"
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O -GlcNAc Modification During Pregnancy: Focus on Placental Environment
Published in Frontiers in physiology (12-09-2018)“…Successful placentation is a key event for fetal development, which commences following embryo implantation into the uterine wall, eliciting decidualization,…”
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Increased expression of STAT3 and SOCS3 in placenta from hyperglycemic rats
Published in European journal of histochemistry (30-10-2019)“…Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated by interleukin (IL)-6 and IL-10 that generate nearly…”
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Evaluation of drug prescriptions for pregnant women in the Legal Amazon Region
Published in Revista Brasileira de Saúde Materno Infantil (01-12-2018)“…Abstract Objectives: to evaluate the drug prescriptions for pregnant women in the Legal Amazon during prenatal care. Methods: this is a…”
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Double-stranded RNA and Toll-like receptor activation: a novel mechanism for blood pressure regulation
Published in Clinical science (1979) (31-01-2020)“…Toll-like receptors (TLRs), such as TLR4 and 9, recognize pathogen-associated molecular pattern (PAMPs) and danger-associated molecular patterns (DAMPs) and…”
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Toll-Like Receptors Contribute to Sex Differences in Blood Pressure Regulation
Published in Journal of cardiovascular pharmacology (01-09-2020)“…Toll-like receptors (TLRs) play an important role in the innate immune system, and recently, they have been shown to be involved in the regulation of blood…”
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Physiological and pathological evidence of O-GlcNAcylation regulation during pregnancy related process
Published in Placenta (Eastbourne) (26-09-2023)“…O-GlcNAcylation is a dynamic and reversible post-translational modification (PTM) controlled by the enzymes O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA)…”
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Macrophage-Specific Toll Like Receptor 9 (TLR9) Causes Corpus Cavernosum Dysfunction in Mice Fed a High Fat Diet
Published in Journal of sexual medicine (01-04-2021)“…Erectile dysfunction (ED) has been shown to be related with inflammatory markers in humans. Chronic infusion of TNF-α caused ED in mice while TNF-α knockout…”
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O-GlcNAc impairs endothelial function in uterine arteries from virgin but not pregnant rats: The role of GSK3β
Published in European journal of pharmacology (05-08-2020)“…Increased O-Linked β-N-acetylglucosamine (O-GlcNAc) is observed in several pathologies, and unbalanced O-GlcNAcylation levels favor endothelial dysfunction…”
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Piezo1 channels mediate vasorelaxation of uterine arteries from pseudopregnant rats
Published in Frontiers in physiology (01-06-2023)“…There is a great increase in uterine arterial blood flow during normal pregnancy, which is a result of the cardiovascular changes that occur in pregnancy to…”
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Piezo1 activation induces relaxation of the pudendal artery and corpus cavernosum
Published in Frontiers in physiology (10-02-2023)“…Piezo1 channel is a sensor for shear-stress in the vasculature. Piezo1 activation induces vasodilation, and its deficiency contributes to vascular disorders,…”
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O-linked N-acetyl-glucosamine deposition in placental proteins varies according to maternal glycemic levels
Published in Life sciences (1973) (15-07-2018)“…Hyperglycemia increases glycosylation with O-linked N‐acetyl‐glucosamine (O-GlcNAc) contributing to placental dysfunction and fetal growth impairment. Our aim…”
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Protein O -GlcNAcylation as a nutrient sensor signaling placental dysfunction in hypertensive pregnancy
Published in Frontiers in endocrinology (Lausanne) (01-12-2022)“…During pregnancy, arterial hypertension may impair placental function, which is critical for a healthy baby's growth. Important proteins during placentation…”
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O-Glycosylation with O-linked β-N-acetylglucosamine increases vascular contraction: Possible modulatory role on Interleukin-10 signaling pathway
Published in Life sciences (1973) (15-09-2018)“…The interleukin-10 (IL-10) is an immuno-regulatory cytokine that plays a protective effect in the vasculature. IL-10 binding to its receptor, activating the…”
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High Levels of Tumor Necrosis Factor-Alpha Reduce Placental Aquaporin 3 Expression and Impair in vitro Trophoblastic Cell Migration
Published in Frontiers in physiology (29-06-2021)“…Placentas from preeclamptic women display augmented tumor necrosis factor-alpha (TNF-α) levels with reduced expression of aquaporin 3 (AQP3). However, whether…”
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Sex Differences in Molecular Mechanisms of Cardiovascular Aging
Published in Frontiers in aging (10-09-2021)“…Cardiovascular disease (CVD) is still the leading cause of illness and death in the Western world. Cardiovascular aging is a progressive modification occurring…”
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Trimethylamine N‐Oxide (TMAO) Impairs Endothelium‐Dependent Relaxation in Mouse Mesenteric Resistance Artery and Aorta
Published in The FASEB journal (01-04-2020)“…Abstract only Trimethylamine N‐oxide (TMAO) is a gut microbiota‐dependent metabolite produced from choline and phosphatidylcholine and it has been related to…”
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Abstract P173: Trimethylamine N-Oxide (TMAO) Impairs Endothelium-Dependent Relaxation of the Mesenteric Artery in Lean and Db/db Mice
Published in Hypertension (Dallas, Tex. 1979) (01-09-2019)“…Abstract only Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite produced from choline and phosphatidylcholine and it has recently been…”
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Evidence of Nitric Oxide Impairment During Hypertensive Pregnancies
Published in Advances in experimental medicine and biology (2023)“…Hypertensive disorders of pregnancy complicate up to 10% of pregnancies worldwide, and they can be classified into (1) gestational hypertension, (2)…”
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Abstract P062: Trimethylamine N-oxide Impairs Endothelium-dependent Relaxation In Aorta Of Non-diabetic And Diabetic Mice
Published in Hypertension (Dallas, Tex. 1979) (01-09-2020)“…Abstract only Trimethylamine N-oxide (TMAO) is a gut microbiota metabolite related with cardiovascular diseases. Circulating levels of TMAO are increased in…”
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Abstract P214: Mechanotransduction And Uterine Blood Flow In Preeclampsia- The Role Of Piezo 1 Ion Channels
Published in Hypertension (Dallas, Tex. 1979) (01-09-2020)“…Abstract only Background: There is a large increase in uterine arterial blood flow during normal pregnancy. Structural and cellular adjustments occur in the…”
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