Search Results - "Del Rio, Marcela"

Clinically Relevant Correction of Recessive Dystrophic Epidermolysis Bullosa by Dual sgRNA CRISPR/Cas9-Mediated Gene Editing by Bonafont, Jose, Mencía, Ángeles, García, Marta, Torres, Raúl, Rodríguez, Sandra, Carretero, Marta, Chacón-Solano, Esteban, Modamio-Høybjør, Silvia, Marinas, Lucía, León, Carlos, Escamez, María J., Hausser, Ingrid, Del Río, Marcela, Murillas, Rodolfo, Larcher, Fernando

“…Gene editing constitutes a novel approach for precisely correcting disease-causing gene mutations. Frameshift mutations in COL7A1 causing recessive dystrophic…”
Get full text

Topical Enzyme-Replacement Therapy Restores Transglutaminase 1 Activity and Corrects Architecture of Transglutaminase-1-Deficient Skin Grafts by Aufenvenne, Karin, Larcher, Fernando, Hausser, Ingrid, Duarte, Blanca, Oji, Vinzenz, Nikolenko, Heike, Del Rio, Marcela, Dathe, Margitta, Traupe, Heiko

“…Transglutaminase-1 (TG1)-deficient autosomal-recessive congenital ichthyosis (ARCI) is a rare and severe genetic skin disease caused by mutations in TGM1. It…”
Get full text

Deletion of a Pathogenic Mutation-Containing Exon of COL7A1 Allows Clonal Gene Editing Correction of RDEB Patient Epidermal Stem Cells by Mencía, Ángeles, Chamorro, Cristina, Bonafont, Jose, Duarte, Blanca, Holguin, Almudena, Illera, Nuria, Llames, Sara G., Escámez, Maria José, Hausser, Ingrid, Del Río, Marcela, Larcher, Fernando, Murillas, Rodolfo

“…Recessive dystrophic epidermolysis bullosa is a severe skin fragility disease caused by loss of functional type VII collagen at the dermal-epidermal junction…”
Get full text

Humanization of Tumor Stroma by Tissue Engineering as a Tool to Improve Squamous Cell Carcinoma Xenograft by Guerrero-Aspizua, Sara, González-Masa, Andrea, Conti, Claudio J, García, Marta, Chacón-Solano, Esteban, Larcher, Fernando, Del Río, Marcela

“…The role of stroma is fundamental in the development and behavior of epithelial tumors. In this regard, limited growth of squamous cell carcinomas (SCC) or…”
Get full text

Gene Editing for the Efficient Correction of a Recurrent COL7A1 Mutation in Recessive Dystrophic Epidermolysis Bullosa Keratinocytes by Chamorro, Cristina, Mencía, Angeles, Almarza, David, Duarte, Blanca, Büning, Hildegard, Sallach, Jessica, Hausser, Ingrid, Del Río, Marcela, Larcher, Fernando, Murillas, Rodolfo

“…Clonal gene therapy protocols based on the precise manipulation of epidermal stem cells require highly efficient gene-editing molecular tools. We have combined…”
Get full text

Early, Non-Invasive Sensing of Sustained Hyperglycemia in Mice Using Millimeter-Wave Spectroscopy by Moreno-Oyervides, Aldo, Martín-Mateos, Pedro, Aguilera-Morillo, M Carmen, Ulisse, Giacomo, Arriba, María C, Durban, María, Rio, Marcela Del, Larcher, Fernando, Krozer, Viktor, Acedo, Pablo

“…Diabetes is a very complex condition affecting millions of people around the world. Its occurrence, always accompanied by sustained hyperglycemia, leads to…”
Get full text

Gene therapy based in antimicrobial peptides and proinflammatory cytokine prevents reactivation of experimental latent tuberculosis by Ramos-Espinosa, Octavio, Hernández-Bazán, Sujhey, Francisco-Cruz, Alejandro, Mata-Espinosa, Dulce, Barrios-Payán, Jorge, Marquina-Castillo, Brenda, López-Casillas, Fernando, Carretero, Marta, del Río, Marcela, Hernández-Pando, Rogelio

“…Mycobacterium tuberculosis (Mtb) latent infection can lead to reactivation. The design of new strategies to prevent it is an important subject. B6D2F1 mice…”
Get full text

1α,25-Dihydroxyvitamin D3 regulates the expression of Id1 and Id2 genes and the angiogenic phenotype of human colon carcinoma cells by FERNANDEZ-GARCIA, Nuria Isabel, PALMER, Hector G, GARCIA, Marta, GONZALEZ-MARTIN, Alicia, DEL RIO, Marcela, BARETTINO, Domingo, VOLPERT, Olga, MUNOZ, Alberto, JIMENEZ, Benilde

“…1α,25-Dihydroxyvitamin D3 (1α,25(OH)2D3) has antitumor activity in addition to its classical action on calcium metabolism and bone tissue biology. It is…”
Get full text

Humoral and Cell-Mediated Immune Responses to Monovalent 2009 Influenza A/H1N1 and Seasonal Trivalent Influenza Vaccines in High-Risk Children by Long, Caroline B., MD, Ramos, Irene, PhD, Rastogi, Deepa, MD, MSc, Manwani, Deepa, MD, Janow, Ginger, MD, Del Rio, Marcela, MD, Mayers, Marguerite, MD, Herold, Betsy C., MD, Fernandez-Sesma, Ana, PhD, Madan, Rebecca Pellett, MD, MSc

“…Objective Humoral and cell-mediated immune responses to monovalent 2009 pandemic influenza A (H1N1/2009) and seasonal trivalent influenza (TIV) vaccines were…”
Get full text

Raloxifene and n-Acetylcysteine Ameliorate TGF-Signalling in Fibroblasts from Patients with Recessive Dominant Epidermolysis Bullosa by Aguado, Tania, García, Marta, García, Adela, Ferrer-Mayorga, Gemma, Martínez-Santamaría, Lucía, Del Río, Marcela, Botella, Luisa-María, Sánchez-Puelles, José-María

“…Recessive dystrophic epidermolysis bullosa (RDEB) is a severe skin disease caused by mutation of the gene. RDEB is associated with high levels of TGF-β1, which…”
Get full text

A humanized mouse model of HPV-associated pathology driven by E7 expression by Buitrago-Pérez, Águeda, Hachimi, Mariam, Dueñas, Marta, Lloveras, Belén, Santos, Almudena, Holguín, Almudena, Duarte, Blanca, Santiago, Juan Luis, Akgül, Baki, Rodríguez-Peralto, José L, Storey, Alan, Ribas, Catalina, Larcher, Fernando, del Rio, Marcela, Paramio, Jesús M, García-Escudero, Ramón

“…Human papillomavirus (HPV) is the causative agent of human cervical cancer and has been associated with oropharyngeal squamous cell carcinoma development…”
Get full text

DNA Repair and Immune Response Pathways Are Deregulated in Melanocyte-Keratinocyte Co-cultures Derived From the Healthy Skin of Familial Melanoma Patients by Potrony, Miriam, Haddad, Tariq Sami, Tell-Martí, Gemma, Gimenez-Xavier, Pol, Leon, Carlos, Pevida, Marta, Mateu, Judit, Badenas, Celia, Carrera, Cristina, Malvehy, Josep, Aguilera, Paula, Llames, Sara, Escámez, Maria José, Puig-Butillé, Joan A., del Río, Marcela, Puig, Susana

“…Familial melanoma accounts for 10% of cases, being CDKN2A the main high-risk gene. However, the mechanisms underlying melanomagenesis in these cases remain…”
Get full text

Beneficial Effect of Systemic Allogeneic Adipose Derived Mesenchymal Cells on the Clinical, Inflammatory and Immunologic Status of a Patient With Recessive Dystrophic Epidermolysis Bullosa: A Case Report by Maseda, Rocío, Martínez-Santamaría, Lucía, Sacedón, Rosa, Butta, Nora, de Arriba, María Del Carmen, García-Barcenilla, Sara, García, Marta, Illera, Nuria, Pérez-Conde, Isabel, Carretero, Marta, Jiménez, Eva, Melen, Gustavo, Borobia, Alberto M, Jiménez-Yuste, Víctor, Vicente, Ángeles, Del Río, Marcela, de Lucas, Raúl, Escámez, María José

“…Recessive dystrophic epidermolysis bullosa (RDEB) is an incurable inherited mucocutaneous fragility disorder characterized by recurrent blisters, erosions, and…”
Get full text

Tacrolimus variability is associated with de novo donor-specific antibody development in pediatric renal transplant recipients by Solomon, Sonia, Colovai, Adriana, Del Rio, Marcela, Hayde, Nicole

“…Background Donor-specific antibody (DSA) is a risk factor for antibody-mediated rejection and shortened graft survival. We investigated the role of…”
Get full text

Feeder Layer Cell Actions and Applications by Llames, Sara, García-Pérez, Eva, Meana, Álvaro, Larcher, Fernando, del Río, Marcela

“…Cultures of growth-arrested feeder cells have been used for years to promote cell proliferation, particularly with low-density inocula. Basically, feeder cells…”
Get more information

Malaria and acute kidney injury by Brown, Denver D., Solomon, Sonia, Lerner, Daniele, Del Rio, Marcela

“…Malaria is a parasitic infection transmitted by mosquitos, resulting in significant morbidity and mortality. It affects 212 million worldwide, causing death in…”
Get full text

Ofatumumab in post‐transplantation recurrence of focal segmental glomerulosclerosis in a child by Solomon, Sonia, Zolotnitskaya, Anna, Del Rio, Marcela

“…FSGS is a potentially devastating form of nephrotic syndrome. Treatment of SRNS can be difficult, especially post‐transplantation. The current therapy of…”
Get full text

CRISPR/Cas9-Mediated In Situ Correction of LAMB3 Gene in Keratinocytes Derived from a Junctional Epidermolysis Bullosa Patient by Benati, Daniela, Miselli, Francesca, Cocchiarella, Fabienne, Patrizi, Clarissa, Carretero, Marta, Baldassarri, Samantha, Ammendola, Virginia, Has, Cristina, Colloca, Stefano, Del Rio, Marcela, Larcher, Fernando, Recchia, Alessandra

“…Deficiency of basement membrane heterotrimeric laminin 332 component, coded by LAMA3, LAMB3, and LAMC2 genes, causes junctional epidermolysis bullosa (JEB), a…”
Get full text

Inhibition of xenografted human melanoma growth and prevention of metastasis development by dual antiangiogenic/antitumor activities of pigment epithelium-derived factor by GARCIA, Marta, FERNANDEZ-GARCIA, Nuria Isabel, LARCHER, Fernando, DEL RIO, Marcela, RIVAS, Veronica, CARRETERO, Marta, ESCAMEZ, Maria J, GONZALEZ-MARTIN, Alicia, MEDRANO, Estela E, VOLPERT, Olga, JORCANO, Jose L, JIMENEZ, Benilde

“…Human melanoma mortality is associated with the growth of metastasis in selected organs including the lungs, liver, and brain. In this study, we examined the…”
Get full text

Amenorrhea in a pediatric kidney transplant recipient: Answers by Steinman, Benjamin, Kilduff, Stella, Del Rio, Marcela, Hayde, Nicole

Get full text