Search Results - "Del Rio, Gabriel"

Protein-Protein Interactions Efficiently Modeled by Residue Cluster Classes by Poot Velez, Albros Hermes, Fontove, Fernando, Del Rio, Gabriel

“…Predicting protein-protein interactions (PPI) represents an important challenge in structural bioinformatics. Current computational methods display different…”
Get full text

Effective Design of Multifunctional Peptides by Combining Compatible Functions by Diener, Christian, Garza Ramos Martínez, Georgina, Moreno Blas, Daniel, Castillo González, David A, Corzo, Gerardo, Castro-Obregon, Susana, Del Rio, Gabriel

“…Multifunctionality is a common trait of many natural proteins and peptides, yet the rules to generate such multifunctionality remain unclear. We propose that…”
Get full text

Embedded-AMP: A Multi-Thread Computational Method for the Systematic Identification of Antimicrobial Peptides Embedded in Proteome Sequences by Carballo, Germán Meléndrez, Vázquez, Karen Guerrero, García-González, Luis A, Rio, Gabriel Del, Brizuela, Carlos A

“…Antimicrobial peptides (AMPs) have gained the attention of the research community for being an alternative to conventional antimicrobials to fight antibiotic…”
Get full text

Anti-cancer activity of targeted pro-apoptotic peptides by Ruoslahti, Erkki, Bredesen, Dale E, Pasqualini, Renata, Ellerby, H. Michael, Arap, Wadih, Ellerby, Lisa M, Kain, Renate, Andrusiak, Rebecca, Rio, Gabriel Del, Krajewski, Stanislaw, Lombardo, Christian R, Rao, Rammohan

“…We have designed short peptides composed of two functional domains, one a tumor blood vessel 'homing' motif and the other a programmed cell death-inducing…”
Get full text

An Antimicrobial Peptide Induces FIG1 -Dependent Cell Death During Cell Cycle Arrest in Yeast by Arellano, Vladimir J, Martinell García, Paula, Rodríguez Plaza, Jonathan G, Lara Ortiz, Maria T, Schreiber, Gabriele, Volkmer, Rudolf, Klipp, Edda, Rio, Gabriel Del

“…Although most antibiotics act on cells that are actively dividing and non-dividing cells such as in microbe sporulation or cancer stem cells represent a new…”
Get full text

Residue Cluster Classes: A Unified Protein Representation for Efficient Structural and Functional Classification by Fontove, Fernando, Del Rio, Gabriel

“…Proteins are characterized by their structures and functions, and these two fundamental aspects of proteins are assumed to be related. To model such a…”
Get full text

Cell‐penetrating peptides predictors: A comparative analysis of methods and datasets by Guerrero‐Vázquez, Karen, Del Rio, Gabriel, Brizuela, Carlos A.

“…Cell‐Penetrating Peptides (CPP) are emerging as an alternative to small‐molecule drugs to expand the range of biomolecules that can be targeted for therapeutic…”
Get full text

Antimicrobial peptides with cell-penetrating activity as prophylactic and treatment drugs by del Rio, Gabriel, Trejo Perez, Mario A., Brizuela, Carlos A.

“…Health is fundamental for the development of individuals and evolution of species. In that sense, for human societies is relevant to understand how the human…”
Get full text

Saturation Mutagenesis of the Transmembrane Region of HokC in Escherichia coli Reveals Its High Tolerance to Mutations by Lara Ortiz, Maria Teresa, Martinell García, Victor, Del Rio, Gabriel

“…Cells adapt to different stress conditions, such as the antibiotics presence. This adaptation sometimes is achieved by changing relevant protein positions, of…”
Get full text

Challenges in the Computational Modeling of the Protein Structure—Activity Relationship by Del Río, Gabriel

“…Living organisms are composed of biopolymers (proteins, nucleic acids, carbohydrates and lipid polymers) that are used to keep or transmit information relevant…”
Get full text

Heterologous Machine Learning for the Identification of Antimicrobial Activity in Human-Targeted Drugs by Nava Lara, Rodrigo A, Aguilera-Mendoza, Longendri, Brizuela, Carlos A, Peña, Antonio, Del Rio, Gabriel

“…The emergence of microbes resistant to common antibiotics represent a current treat to human health. It has been recently recognized that non-antibiotic…”
Get full text

Systematic Identification of Machine-Learning Models Aimed to Classify Critical Residues for Protein Function from Protein Structure by Corral-Corral, Ricardo, Beltrán, Jesús A, Brizuela, Carlos A, Del Rio, Gabriel

“…Protein structure and protein function should be related, yet the nature of this relationship remains unsolved. Mapping the critical residues for protein…”
Get full text

Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway by Rao, Rammohan V, Castro-Obregon, Susana, Frankowski, Harald, Schuler, Martin, Stoka, Veronica, del Rio, Gabriel, Bredesen, Dale E, Ellerby, H Michael

“…Accumulation of misfolded proteins and alterations in Ca2+ homeostasis in the endoplasmic reticulum (ER) causes ER stress and leads to cell death. However, the…”
Get full text

An automatic representation of peptides for effective antimicrobial activity classification by Beltran, Jesus A., Del Rio, Gabriel, Brizuela, Carlos A.

“…[Display omitted] Antimicrobial peptides (AMPs) are a promising alternative to small-molecules-based antibiotics. These peptides are part of most living…”
Get full text

Yeast mating and image-based quantification of spatial pattern formation by Diener, Christian, Schreiber, Gabriele, Giese, Wolfgang, del Rio, Gabriel, Schröder, Andreas, Klipp, Edda

“…Communication between cells is a ubiquitous feature of cell populations and is frequently realized by secretion and detection of signaling molecules. Direct…”
Get full text

Selective Moonlighting Cell-Penetrating Peptides by Morán-Torres, Rafael, Castillo González, David A, Durán-Pastén, Maria Luisa, Aguilar-Maldonado, Beatriz, Castro-Obregón, Susana, Del Rio, Gabriel

“…Cell penetrating peptides (CPPs) are molecules capable of passing through biological membranes. This capacity has been used to deliver impermeable molecules…”
Get full text

Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78 by Rao, Rammohan V., Peel, Alyson, Logvinova, Anna, del Rio, Gabriel, Hermel, Evan, Yokota, Takanori, Goldsmith, Paul C., Ellerby, Lisa M., Ellerby, H.Michael, Bredesen, Dale E.

“…Alterations in Ca 2+ homeostasis and accumulation of unfolded proteins in the endoplasmic reticulum (ER) lead to an ER stress response. Prolonged ER stress may…”
Get full text

Antimicrobial Peptide against Mycobacterium Tuberculosis That Activates Autophagy Is an Effective Treatment for Tuberculosis by Peláez Coyotl, Erika A., Barrios Palacios, Jacqueline, Muciño, Gabriel, Moreno-Blas, Daniel, Costas, Miguel, Montiel Montes, Teresa, Diener, Christian, Uribe-Carvajal, Salvador, Massieu, Lourdes, Castro-Obregón, Susana, Espinosa, Octavio Ramos, Mata Espinosa, Dulce, Barrios-Payan, Jorge, León Contreras, Juan Carlos, Corzo, Gerardo, Hernández-Pando, Rogelio, Del Rio, Gabriel

“…Mycobacterium tuberculosis (MTB) is the principal cause of human tuberculosis (TB), which is a serious health problem worldwide. The development of innovative…”
Get full text

The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase by Llambi, Fabien, Lourenço, Filipe Calheiros, Gozuacik, Devrim, Guix, Catherine, Pays, Laurent, Del Rio, Gabriel, Kimchi, Adi, Mehlen, Patrick

“…Netrin‐1 receptors UNC5H (UNC5H1–4) were originally proposed to mediate the chemorepulsive activity of netrin‐1 during axonal guidance processes. However,…”
Get full text

Relevant Features of Polypharmacologic Human-Target Antimicrobials Discovered by Machine-Learning Techniques by Nava Lara, Rodrigo A., Beltrán, Jesús A., Brizuela, Carlos A., Del Rio, Gabriel

“…Polypharmacologic human-targeted antimicrobials (polyHAM) are potentially useful in the treatment of complex human diseases where the microbiome is important…”
Get full text