Search Results - "Del Re, Dominic"

Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease by Del Re, Dominic P, Amgalan, Dulguun, Linkermann, Andreas, Liu, Qinghang, Kitsis, Richard N

“…Twelve regulated cell death programs have been described. We review in detail the basic biology of nine including death receptor-mediated apoptosis, death…”
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Decoding the Impact of the Hippo Pathway on Different Cell Types in Heart Failure by Hu, Chengchen, Francisco, Jamie, Re, Dominic P. Del, Sadoshima, Junichi

“…The evolutionarily conserved Hippo pathway plays a pivotal role in governing a variety of biological processes. Heart failure (HF) is a major global health…”
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Mst1 Promotes Cardiac Myocyte Apoptosis through Phosphorylation and Inhibition of Bcl-xL by Del Re, Dominic P., Matsuda, Takahisa, Zhai, Peiyong, Maejima, Yasuhiro, Jain, Mohit Raja, Liu, Tong, Li, Hong, Hsu, Chiao-Po, Sadoshima, Junichi

“…The Hippo pathway, evolutionarily conserved from flies to mammals, promotes cell death and inhibits cell proliferation to regulate organ size. The core…”
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AAV-mediated YAP expression in cardiac fibroblasts promotes inflammation and increases fibrosis by Francisco, Jamie, Zhang, Yu, Nakada, Yasuki, Jeong, Jae Im, Huang, Chun-Yang, Ivessa, Andreas, Oka, Shinichi, Babu, Gopal J., Del Re, Dominic P.

“…Fibrosis is a hallmark of heart disease independent of etiology and is thought to contribute to impaired cardiac dysfunction and development of heart failure…”
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mTORC2 Regulates Cardiac Response to Stress by Inhibiting MST1 by Sciarretta, Sebastiano, Zhai, Peiyong, Maejima, Yasuhiro, Del Re, Dominic P., Nagarajan, Narayani, Yee, Derek, Liu, Tong, Magnuson, Mark A., Volpe, Massimo, Frati, Giacomo, Li, Hong, Sadoshima, Junichi

“…The mTOR and Hippo pathways have recently emerged as the major signaling transduction cascades regulating organ size and cellular homeostasis. However, direct…”
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Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction by Sciarretta, Sebastiano, Yee, Derek, Nagarajan, Narayani, Bianchi, Franca, Saito, Toshiro, Valenti, Valentina, Tong, Mingming, Del Re, Dominic P., Vecchione, Carmine, Schirone, Leonardo, Forte, Maurizio, Rubattu, Speranza, Shirakabe, Akihiro, Boppana, V. Subbarao, Volpe, Massimo, Frati, Giacomo, Zhai, Peiyong, Sadoshima, Junichi

“…Trehalose (TRE) is a natural, nonreducing disaccharide synthesized by lower organisms. TRE exhibits an extraordinary ability to protect cells against different…”
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Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2 by Maejima, Yasuhiro, Kyoi, Shiori, Zhai, Peiyong, Liu, Tong, Li, Hong, Ivessa, Andreas, Sciarretta, Sebastiano, Del Re, Dominic P, Zablocki, Daniela K, Hsu, Chiao-Po, Lim, Dae-Sik, Isobe, Mitsuaki, Sadoshima, Junichi

“…The kinase Mst1, which acts in the Hippo pathway, controls cell proliferation, differentiation and apoptosis. Junichi Sadoshima and his colleagues show that…”
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Inflammation in Myocardial Ischemia/Reperfusion Injury: Underlying Mechanisms and Therapeutic Potential by Francisco, Jamie, Del Re, Dominic P

“…Acute myocardial infarction (MI) occurs when blood flow to the myocardium is restricted, leading to cardiac damage and massive loss of viable cardiomyocytes…”
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Hippo Signaling in the Heart　– Non-Canonical Pathways Impact Growth, Survival and Function by Re, Dominic P. Del

“…Initially identified inDrosophila melanogaster, the Hippo signaling pathway regulates organ size through modulation of cell proliferation, survival and…”
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Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy in response to pressure overload by Byun, Jaemin, Del Re, Dominic P., Zhai, Peiyong, Ikeda, Shohei, Shirakabe, Akihiro, Mizushima, Wataru, Miyamoto, Shigeki, Brown, Joan H., Sadoshima, Junichi

“…Cardiovascular disease (CVD) remains the leading cause of death globally, and heart failure is a major component of CVD-related morbidity and mortality. The…”
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miR-206 Mediates YAP-Induced Cardiac Hypertrophy and Survival by Yang, Yanfei, Del Re, Dominic P, Nakano, Noritsugu, Sciarretta, Sebastiano, Zhai, Peiyong, Park, Jiyeon, Sayed, Danish, Shirakabe, Akihiro, Matsushima, Shoji, Park, Yongkyu, Tian, Bin, Abdellatif, Maha, Sadoshima, Junichi

“…RATIONALE:In Drosophila, the Hippo signaling pathway negatively regulates organ size by suppressing cell proliferation and survival through the inhibition of…”
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NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the Heart by Matsuda, Takahisa, Zhai, Peiyong, Sciarretta, Sebastiano, Zhang, Yu, Jeong, Jae Im, Ikeda, Shohei, Park, Jiyeon, Hsu, Chiao-Po, Tian, Bin, Pan, Duojia, Sadoshima, Junichi, Del Re, Dominic P

“…RATIONALE:NF2 (neurofibromin 2) is an established tumor suppressor that promotes apoptosis and inhibits growth in a variety of cell types, yet its function in…”
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Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload by Shao, Dan, Zhai, Peiyong, Hu, Chengchen, Mukai, Risa, Sciarretta, Sebastiano, Del Re, Dominic, Sadoshima, Junichi

“…The Hippo pathway plays a wide variety of roles in response to stress in the heart. Lats2, a component of the Hippo pathway, is phosphorylated by Mst1/2 and,…”
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Yes-associated Protein Isoform 1 (Yap1) Promotes Cardiomyocyte Survival and Growth to Protect against Myocardial Ischemic Injury by Del Re, Dominic P., Yang, Yanfei, Nakano, Noritsugu, Cho, Jaeyeaon, Zhai, Peiyong, Yamamoto, Takanobu, Zhang, Nailing, Yabuta, Norikazu, Nojima, Hiroshi, Pan, Duojia, Sadoshima, Junichi

“…Yap1 is an important regulator of cardiomyocyte proliferation and embryonic heart development, yet the function of endogenous Yap1 in the adult heart remains…”
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Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload by Ikeda, Shohei, Mizushima, Wataru, Sciarretta, Sebastiano, Abdellatif, Maha, Zhai, Peiyong, Mukai, Risa, Fefelova, Nadezhda, Oka, Shin-ichi, Nakamura, Michinari, Del Re, Dominic P, Farrance, Iain, Park, Ji Yeon, Tian, Bin, Xie, Lai-Hua, Kumar, Mohit, Hsu, Chiao-Po, Sadayappan, Sakthivel, Shimokawa, Hiroaki, Lim, Dae-Sik, Sadoshima, Junichi

“…RATIONALE:The Hippo pathway plays an important role in determining organ size through regulation of cell proliferation and apoptosis. Hippo inactivation and…”
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Guidelines for in vivo mouse models of myocardial infarction by Lindsey, Merry L, Brunt, Keith R, Kirk, Jonathan A, Kleinbongard, Petra, Calvert, John W, de Castro Brás, Lisandra E, DeLeon-Pennell, Kristine Y, Del Re, Dominic P, Frangogiannis, Nikolaos G, Frantz, Stefan, Gumina, Richard J, Halade, Ganesh V, Jones, Steven P, Ritchie, Rebecca H, Spinale, Francis G, Thorp, Edward B, Ripplinger, Crystal M, Kassiri, Zamaneh

“…Despite significant improvements in reperfusion strategies, acute coronary syndromes all too often culminate in a myocardial infarction (MI). The consequent MI…”
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Suppression of myeloid YAP antagonizes adverse cardiac remodeling during pressure overload stress by Francisco, Jamie, Guan, Jin, Zhang, Yu, Nakada, Yasuki, Mareedu, Satvik, Sung, Eun-Ah, Hu, Che-Ming, Oka, Shinichi, Zhai, Peiyong, Sadoshima, Junichi, Del Re, Dominic P.

“…Inflammation is an integral component of cardiovascular disease and is thought to contribute to cardiac dysfunction and heart failure. While ischemia-induced…”
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Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice by Nakamura, Michinari, Keller, Mariko Aoyagi, Fefelova, Nadezhda, Zhai, Peiyong, Liu, Tong, Tian, Yimin, Ikeda, Shohei, Del Re, Dominic P., Li, Hong, Xie, Lai-Hua, Sadoshima, Junichi

“…The anti-apoptotic function of Bcl-xL in the heart during ischemia/reperfusion is diminished by K-Ras-Mst1-mediated phosphorylation of Ser14, which allows…”
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The Hippo signal transduction network in skeletal and cardiac muscle by Wackerhage, Henning, Del Re, Dominic P, Judson, Robert N, Sudol, Marius, Sadoshima, Junichi

“…The discovery of the Hippo pathway can be traced back to two areas of research. Genetic screens in fruit flies led to the identification of the Hippo pathway…”
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Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition by Francisco, Jamie, Zhang, Yu, Jeong, Jae Im, Mizushima, Wataru, Ikeda, Shohei, Ivessa, Andreas, Oka, Shinichi, Zhai, Peiyong, Tallquist, Michelle D., Del Re, Dominic P.

“…[Display omitted] •YAP is activated by myocardial infarction or neuroendocrine stimulation in cardiac fibroblasts.•Active YAP promotes TEA domain transcription…”
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