Search Results - "Del Río, Marcela"
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The importance of immunity in the development of reliable animal models for psoriasis and atopic dermatitis
Published in Immunology and cell biology (01-09-2020)“…Psoriasis (PS) and atopic dermatitis (AD) are common inflammatory skin diseases characterized by an imbalance in specific T‐cell subsets, resulting in a…”
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In vitro and In vivo Wound Healing-Promoting Activities of Human Cathelicidin LL-37
Published in Journal of investigative dermatology (01-01-2008)“…The human antimicrobial peptide LL-37 plays an important role in host defense against infection. In addition to its antimicrobial action, other activities have…”
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Unveiling the value of C‐reactive protein as a severity biomarker and the IL4/IL13 pathway as a therapeutic target in recessive dystrophic epidermolysis bullosa: A multiparametric cross‐sectional study
Published in Experimental dermatology (01-08-2024)“…Patients with recessive dystrophic epidermolysis bullosa (RDEB) experience numerous complications, which are exacerbated by inflammatory dysregulation and…”
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4
Long-Term Skin Regeneration From a Gene-Targeted Human Epidermal Stem Cell Clone
Published in Molecular therapy (01-11-2014)Get full text
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5
Capturing the biological impact of CDKN2A and MC1R genes as an early predisposing event in melanoma and non melanoma skin cancer
Published in Oncotarget (30-03-2014)“…Germline mutations in CDKN2A and/or red hair color variants in MC1R genes are associated with an increased susceptibility to develop cutaneous melanoma or non…”
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Genomic expression differences between cutaneous cells from red hair color individuals and black hair color individuals based on bioinformatic analysis
Published in Oncotarget (14-02-2017)“…The MC1R gene plays a crucial role in pigmentation synthesis. Loss-of-function MC1R variants, which impair protein function, are associated with red hair color…”
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7
IKKα regulates the stratification and differentiation of the epidermis: implications for skin cancer development
Published in Oncotarget (22-11-2016)“…IKKα plays a mandatory role in keratinocyte differentiation and exerts an important task in non-melanoma skin cancer development. However, it is not fully…”
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Trends of maxillofacial trauma: An update from the prospective register of a multicenter study in emergency services of Chile
Published in Medicina oral, patología oral y cirugía bucal (01-09-2019)“…Determine the behavior of the maxillofacial trauma of adults treated in 3 tertiary care centers in the central zone of Chile. descriptive, cross-sectional,…”
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An In Vivo Model of Wound Healing in Genetically Modified Skin-Humanized Mice
Published in Journal of investigative dermatology (01-12-2004)“…Cutaneous wound-healing disorders are a major health problem that requires the development of innovative treatments. Whithin this context, the search for…”
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10
The effect of benzo[a]pyrene on the gut microbiota of Nile tilapia (Oreochromis niloticus)
Published in Applied microbiology and biotechnology (01-10-2021)“…Benzo[a]pyrene (BaP) is a highly toxic and carcinogenic polycyclic aromatic hydrocarbon (PAH) whose toxicological effects in the gut microbiota of aquatic…”
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Toxicity evaluation and microbiota response of the lined sole Achirus lineatus (Chordata: Achiridae) exposed to the light petroleum water-accommodated fraction (WAF)
Published in Journal of Toxicology and Environmental Health, Part A (17-04-2020)“…Exposure to contaminants might directly affect organisms and alter their associated microbiota. The objective of the present study was to determine the impact…”
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12
Partial mRNA Sequences of the Biomarkers CYP1A, GST, CAT, GR, SOD, GPx, VTG and p53 in Flatfish Syacium gunteri from Gulf of Mexico
Published in Bulletin of environmental contamination and toxicology (01-06-2018)“…The present study reports partial sequences of a group of genes used as exposure and effect biomarkers of organic contaminants and/or heavy metals in Syacium…”
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Clinically Relevant Correction of Recessive Dystrophic Epidermolysis Bullosa by Dual sgRNA CRISPR/Cas9-Mediated Gene Editing
Published in Molecular therapy (08-05-2019)“…Gene editing constitutes a novel approach for precisely correcting disease-causing gene mutations. Frameshift mutations in COL7A1 causing recessive dystrophic…”
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14
Gill and liver transcriptomic responses of Achirus lineatus (Neopterygii: Achiridae) exposed to water-accommodated fraction (WAF) of light crude oil reveal an onset of hypoxia-like condition
Published in Environmental science and pollution research international (01-07-2021)“…Crude oil is one of the most widespread pollutants released into the marine environment, and native species have provided useful information about the effect…”
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15
Effects of photodynamic therapy on dermal fibroblasts from xeroderma pigmentosum and Gorlin-Goltz syndrome patients
Published in Oncotarget (29-09-2017)“…PDT is widely applied for the treatment of non-melanoma skin cancer pre-malignant and malignant lesions (actinic keratosis, basal cell carcinoma and squamous…”
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Topical Enzyme-Replacement Therapy Restores Transglutaminase 1 Activity and Corrects Architecture of Transglutaminase-1-Deficient Skin Grafts
Published in American journal of human genetics (03-10-2013)“…Transglutaminase-1 (TG1)-deficient autosomal-recessive congenital ichthyosis (ARCI) is a rare and severe genetic skin disease caused by mutations in TGM1. It…”
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Deletion of a Pathogenic Mutation-Containing Exon of COL7A1 Allows Clonal Gene Editing Correction of RDEB Patient Epidermal Stem Cells
Published in Molecular therapy. Nucleic acids (01-06-2018)“…Recessive dystrophic epidermolysis bullosa is a severe skin fragility disease caused by loss of functional type VII collagen at the dermal-epidermal junction…”
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18
Humanization of Tumor Stroma by Tissue Engineering as a Tool to Improve Squamous Cell Carcinoma Xenograft
Published in International journal of molecular sciences (12-03-2020)“…The role of stroma is fundamental in the development and behavior of epithelial tumors. In this regard, limited growth of squamous cell carcinomas (SCC) or…”
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Combined adipose mesenchymal stromal cell advanced therapy resolved a recalcitrant leg ulcer in an 85-year-old patient
Published in Regenerative medicine (01-09-2020)“…Venous leg ulcers (VLU) represent an uphill economic, health and social burden, aggravated in the elderly. Best-practice care interventions are often…”
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Transcriptomic Analysis of a Diabetic Skin-Humanized Mouse Model Dissects Molecular Pathways Underlying the Delayed Wound Healing Response
Published in Genes (31-12-2020)“…Defective healing leading to cutaneous ulcer formation is one of the most feared complications of diabetes due to its consequences on patients' quality of life…”
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