Usefulness of Procalcitonin Levels for Predicting the Microbiological Orientation in Patients with Sepsis

Usefulness of Procalcitonin Levels for Predicting the Microbiological Orientation in Patients with Sepsis

The main objective of the study was to verify whether levels of procalcitonin (PCT) could guide us toward determining the type of bacteria causing the sepsis and to identify the discriminatory cut-off point in the first urgent laboratory test. This study is a single center retrospective analysis tha...

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Bibliographic Details
Published in:Journal of personalized medicine Vol. 14; no. 2; p. 208
Main Authors: Gómez, Natalia Fernanda Pascual, Del Pilar Sanz Martín, María, Chong, María Auxiliadora Semiglia, Cruz, Nelly Daniela Zurita, Hernández, Rosa Méndez, Molina, Iñigo Guerra, Sanz, Iñigo García, Tejerina, Angels Figuerola, Rueda, Fernando Ramasco
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01-02-2024
Subjects:
Bacteria
Biomarkers
Blood
Blood tests
Health aspects
Hospitals
Infection
Laboratories
Medical examination
Medical research
Medicine, Experimental
Microbiology
Patients
Procalcitonin
Sepsis
Septic shock
Statistical analysis
Taiwan
Spain
United States > US
microbiology
procalcitonin
sepsis code
biomarkers
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Summary:The main objective of the study was to verify whether levels of procalcitonin (PCT) could guide us toward determining the type of bacteria causing the sepsis and to identify the discriminatory cut-off point in the first urgent laboratory test. This study is a single center retrospective analysis that includes 371 patients with a mean age of 71.7 ± 15.6 years who were diagnosed with sepsis or septic shock. The yield of blood cultures in demonstrating the causative microbiological agent was 24.3% (90), and it was 57, 1% (212) when evaluating all types of cultures. Statistically significant positive differences were observed in the mean value of the PCT between the group that obtained positive cultures and the group that did not ( < 0.0001). The AUC-ROC of PCT values as a guide to the causal bacteria type was 0.68 (95%CI: 0.57-0.78, < 0.0021). The PCT value that showed the best diagnostic characteristics for identifying Gram-negative rods (GNR) as the causative agent in blood cultures was 2.1 ng/mL. The positive predictive value (PPV) was 78, 9% (66.3-88.1%). The AUC-ROC of the PCT values for sepsis diagnosis, with any positive culture that could be assessed, was 0.67 (95%CI: 0.63-0.73, < 0.0001). The PCT value that showed the best diagnostic characteristic for predicting sepsis was 3.6 ng/mL.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm14020208