Search Results - "Del Greco, Fabiola"

A framework for the investigation of pleiotropy in two‐sample summary data Mendelian randomization by Bowden, Jack, Del Greco M, Fabiola, Minelli, Cosetta, Davey Smith, George, Sheehan, Nuala, Thompson, John

“…Mendelian randomization (MR) uses genetic data to probe questions of causality in epidemiological research, by invoking the Instrumental Variable (IV)…”
Get full text

Mendelian Randomization as an Approach to Assess Causality Using Observational Data by Sekula, Peggy, Del Greco M, Fabiola, Pattaro, Cristian, Köttgen, Anna

“…Mendelian randomization refers to an analytic approach to assess the causality of an observed association between a modifiable exposure or risk factor and a…”
Get full text

Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression by Bowden, Jack, Spiller, Wesley, Del Greco M, Fabiola, Sheehan, Nuala, Thompson, John, Minelli, Cosetta, Davey Smith, George

“…Abstract Background Summary data furnishing a two-sample Mendelian randomization (MR) study are often visualized with the aid of a scatter plot, in which…”
Get full text

Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome by Greco M, Fabiola Del, Minelli, Cosetta, Sheehan, Nuala A, Thompson, John R

“…Mendelian randomisation (MR) estimates causal effects of modifiable phenotypes on an outcome by using genetic variants as instrumental variables, but its…”
Get full text

Mendelian randomization: Progressing towards understanding causality by König, Inke R., Greco, Fabiola M. Del

Get full text

Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci by Jones, Samuel E, Tyrrell, Jessica, Wood, Andrew R, Beaumont, Robin N, Ruth, Katherine S, Tuke, Marcus A, Yaghootkar, Hanieh, Hu, Youna, Teder-Laving, Maris, Hayward, Caroline, Roenneberg, Till, Wilson, James F, Del Greco, Fabiola, Hicks, Andrew A, Shin, Chol, Yun, Chang-Ho, Lee, Seung Ku, Metspalu, Andres, Byrne, Enda M, Gehrman, Philip R, Tiemeier, Henning, Allebrandt, Karla V, Freathy, Rachel M, Murray, Anna, Hinds, David A, Frayling, Timothy M, Weedon, Michael N

“…Disrupted circadian rhythms and reduced sleep duration are associated with several human diseases, particularly obesity and type 2 diabetes, but until…”
Get full text

Thyroid Function and Mood Disorders: A Mendelian Randomization Study by Kuś, Aleksander, Kjaergaard, Alisa D, Marouli, Eirini, Del Greco M, Fabiola, Sterenborg, Rosalie B T M, Chaker, Layal, Peeters, Robin P, Bednarczuk, Tomasz, Åsvold, Bjørn O, Burgess, Stephen, Deloukas, Panos, Teumer, Alexander, Ellervik, Christina, Medici, Marco

“…Observational studies suggest that even minor variations in thyroid function are associated with the risk of mood disorders, including major depressive…”
Get more information

Thyroid Function Affects the Risk of Stroke via Atrial Fibrillation: A Mendelian Randomization Study by Marouli, Eirini, Kus, Aleksander, Del Greco M, Fabiola, Chaker, Layal, Peeters, Robin, Teumer, Alexander, Deloukas, Panos, Medici, Marco

“…Abstract Context Observational studies suggest that variations in normal range thyroid function are associated with cardiovascular diseases. However, it…”
Get full text

Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic by Bowden, Jack, Del Greco M, Fabiola, Minelli, Cosetta, Davey Smith, George, Sheehan, Nuala A, Thompson, John R

“…: MR-Egger regression has recently been proposed as a method for Mendelian randomization (MR) analyses incorporating summary data estimates of causal effect…”
Get full text

The use of two-sample methods for Mendelian randomization analyses on single large datasets by Minelli, Cosetta, Del Greco M., Fabiola, van der Plaat, Diana A, Bowden, Jack, Sheehan, Nuala A, Thompson, John

“…Abstract Background With genome-wide association data for many exposures and outcomes now available from large biobanks, one-sample Mendelian randomization…”
Get full text

Age at menarche and adult body mass index: a Mendelian randomization study by Gill, Dipender, Brewer, Christopher F., Del Greco M, Fabiola, Sivakumaran, Prasanthi, Bowden, Jack, Sheehan, Nuala A., Minelli, Cosetta

“…Background Pubertal timing has psychological and physical sequelae. While observational studies have demonstrated an association between age at menarche and…”
Get full text

Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study by Pichler, Irene, Del Greco M, Fabiola, Gögele, Martin, Lill, Christina M, Bertram, Lars, Do, Chuong B, Eriksson, Nicholas, Foroud, Tatiana, Myers, Richard H, Nalls, Michael, Keller, Margaux F, Benyamin, Beben, Whitfield, John B, Pramstaller, Peter P, Hicks, Andrew A, Thompson, John R, Minelli, Cosetta

“…Although levels of iron are known to be increased in the brains of patients with Parkinson disease (PD), epidemiological evidence on a possible effect of iron…”
Get full text

Asthma and incident coronary heart disease: an observational and Mendelian randomisation study by Valencia-Hernández, Carlos A, Del Greco M, Fabiola, Sundaram, Varun, Portas, Laura, Minelli, Cosetta, Bloom, Chloe I

“…Observational studies suggest asthma is a risk factor for coronary heart disease (CHD) and sex modifies the risk, but they may suffer from methodological…”
Get more information

The causal relationship between gastro-oesophageal reflux disease and idiopathic pulmonary fibrosis: a bidirectional two-sample Mendelian randomisation study by Reynolds, Carl J, Del Greco M, Fabiola, Allen, Richard J, Flores, Carlos, Jenkins, R Gisli, Maher, Toby M, Molyneaux, Philip L, Noth, Imre, Oldham, Justin M, Wain, Louise V, An, Jiyuan, Ong, Jue-Sheng, MacGregor, Stuart, Yates, Tom A, Cullinan, Paul, Minelli, Cosetta

“…Gastro-oesophageal reflux disease (GORD) is associated with idiopathic pulmonary fibrosis (IPF) in observational studies. It is not known if this association…”
Get full text

Evaluating the current state of Mendelian randomization studies: a protocol for a systematic review on methodological and clinical aspects using neurodegenerative disorders as outcome by Grover, Sandeep, Del Greco M, Fabiola, König, Inke R

“…Mendelian randomization (MR) is fast becoming a popular method to judge causality from routinely conducted observational studies. However, stringent underlying…”
Get full text

A multi-omics study of circulating phospholipid markers of blood pressure by Liu, Jun, de Vries, Paul S., Del Greco M., Fabiola, Johansson, Åsa, Schraut, Katharina E., Hayward, Caroline, van Dijk, Ko Willems, Franco, Oscar. H., Hicks, Andrew A., Vitart, Veronique, Rudan, Igor, Campbell, Harry, Polašek, Ozren, Pramstaller, Peter P., Wilson, James F., Gyllensten, Ulf, van Duijn, Cornelia M., Dehghan, Abbas, Demirkan, Ayşe

“…High-throughput techniques allow us to measure a wide-range of phospholipids which can provide insight into the mechanisms of hypertension. We aimed to conduct…”
Get full text

Genetic determinants of complement activation in the general population by Noce, Damia, Foco, Luisa, Orth-Höller, Dorothea, König, Eva, Barbieri, Giulia, Pietzner, Maik, Ghasemi-Semeskandeh, Dariush, Coassin, Stefan, Fuchsberger, Christian, Gögele, Martin, Del Greco M., Fabiola, De Grandi, Alessandro, Summerer, Monika, Wheeler, Eleanor, Langenberg, Claudia, Lass-Flörl, Cornelia, Pramstaller, Peter Paul, Kronenberg, Florian, Würzner, Reinhard, Pattaro, Cristian

“…Complement is a fundamental innate immune response component. Its alterations are associated with severe systemic diseases. To illuminate the complement’s…”
Get full text

Mendelian Randomization by Grover, Sandeep, Del Greco M, Fabiola, Stein, Catherine M, Ziegler, Andreas

“…Confounding and reverse causality have prevented us from drawing meaningful clinical interpretation even in well-powered observational studies. Confounding may…”
Get more information

Whole Exome Sequencing Enhanced Imputation Identifies 85 Metabolite Associations in the Alpine CHRIS Cohort by König, Eva, Rainer, Johannes, Hernandes, Vinicius Verri, Paglia, Giuseppe, Del Greco M, Fabiola, Bottigliengo, Daniele, Yin, Xianyong, Chan, Lap Sum, Teumer, Alexander, Pramstaller, Peter P, Locke, Adam E, Fuchsberger, Christian

“…Metabolites are intermediates or end products of biochemical processes involved in both health and disease. Here, we take advantage of the well-characterized…”
Get full text

The Effect of Iron Status on Risk of Coronary Artery Disease: A Mendelian Randomization Study—Brief Report by Gill, Dipender, Del Greco M, Fabiola, Walker, Ann P, Srai, Surjit K.S, Laffan, Michael A, Minelli, Cosetta

“…OBJECTIVE—Iron status is a modifiable trait that has been implicated in cardiovascular disease. This study uses the Mendelian randomization technique to…”
Get full text