Search Results - "Del Bello, B."

Cross-talk between calpain and caspase-3 -7 in cisplatin-induced apoptosis of melanoma cells: a major role of calpain inhibition in cell death protection and p53 status by DEL BELLO, B, MORETTI, D, GAMBERUCCI, A, MAELLARO, E

“…The contribution of different proteolytic systems, in particular calpains and effector caspases, in apoptotic cell death is still controversial. In this paper,…”
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Novel variants of muscle calpain 3 identified in human melanoma cells: cisplatin-induced changes in vitro and differential expression in melanocytic lesions by Moretti, D., Del Bello, B., Cosci, E., Biagioli, M., Miracco, C., Maellaro, E.

“…Calpains are cysteine proteases comprising members ubiquitously expressed in human tissues and other tissue-specific isoforms. Alterations of calpain 3 (p94),…”
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Purification and characterization of glutathione-dependent dehydroascorbate reductase from rat liver by MAELLARO, E, DEL BELLO, B, SUGHERINI, L, SANTUCCI, A, COMPORTI, M, CASINI, A. F

“…GSH-dependent enzymic reduction of dehydroascorbic acid to ascorbic acid has been studied in rat liver cytosol. After gel filtration of cytosol on Sephadex…”
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Membrane gamma-glutamyl transpeptidase activity of melanoma cells: effects on cellular H2O2 production, cell surface protein thiol oxidation and NF-κB activation status by Maellaro, Emilia, Dominici, Silvia, Bello, Barbara Del, Valentini, Marta A., Pieri, Lisa, Perego, Paola, Supino, Rosanna, Zunino, Franco, Lorenzini, Evelina, Paolicchi, Aldo, Comporti, Mario, Pompella, Alfonso

“…The metabolism of glutathione by membrane-bound gamma-glutamyl transpeptidase (GGT) has been recently recognized as a basal source of hydrogen peroxide in the…”
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Protection by ascorbic acid against oxidative injury of isolated hepatocytes by Maellaro, E, Del Bello, B, Sugherini, L, Pompella, A, Casini, A F, Comporti, M

“…1. The ability of ascorbic acid to protect from prooxidant-induced toxic injury was investigated in isolated, intact rat hepatocytes, whose ascorbic acid…”
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Different effects of interferon-α on melanoma cell lines: a study on telomerase reverse transcriptase, telomerase activity and apoptosis by Maellaro, E., Pacenti, L., Del Bello, B., Valentini, M.A., Mangiavacchi, P., De Felice, C., Rubegni, P., Luzi, P., Miracco, C.

“…Summary Background Although the antiproliferative and proapoptotic effects of interferon (IFN)‐α are widely recognized, its antitumour mechanisms are not…”
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Purification of NADPH-dependent dehydroascorbate reductase from rat liver and its identification with 3 alpha-hydroxysteroid dehydrogenase by Del Bello, B, Maellaro, E, Sugherini, L, Santucci, A, Comporti, M, Casini, A F

“…Rat liver cytosol has been found to reduce dehydroascorbic acid (DHAA) to ascorbic acid in the presence of NADPH. The enzyme responsible for such activity has…”
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Glutathione depletion: its effects on other antioxidant systems and hepatocellular damage by Comporti, M, Maellaro, E, Del Bello, B, Casini, A F

“…1. The mechanisms of the liver damage produced by three glutathione (GSH)-depleting agents, bromobenzene, allyl alcohol and diethyl maleate, were investigated…”
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Redox modulation of cell surface protein thiols in U937 lymphoma cells: the role of gamma-glutamyl transpeptidase-dependent H2O2 production and S-thiolation by Dominici, S, Valentini, M, Maellaro, E, Del Bello, B, Paolicchi, A, Lorenzini, E, Tongiani, R, Comporti, M, Pompella, A

“…The expression of gamma-glutamyl transpeptidase (GGT), a plasma membrane ectoenzyme involved in the metabolism of extracellular reduced glutathione (GSH), is a…”
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Loss of MYC Confers Resistance to Doxorubicin-induced Apoptosis by Preventing the Activation of Multiple Serine Protease- and Caspase-mediated Pathways by Grassilli, Emanuela, Ballabeni, Andrea, Maellaro, Emilia, Del Bello, Barbara, Helin, Kristian

“…c-Myc plays an essential role in proliferation, differentiation, and apoptosis. Because of its relevance to cancer, most studies have focused on the cellular…”
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Role of caspases-3 and -7 in Apaf-1 proteolytic cleavage and degradation events during cisplatin-induced apoptosis in melanoma cells by Del Bello, Barbara, Valentini, Marta A, Mangiavacchi, Paola, Comporti, Mario, Maellaro, Emilia

“…Apoptosis protease-activating factor-1 (Apaf-1), the central element in the mitochondrial pathway of apoptosis, is frequently absent or poorly expressed in…”
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SENSITIVITY OF HUMAN METASTATIC MELANOMA CELLS TO THE ESTER ANALOG OF RAPAMYCIN, CCI-779 by Maellaro, E, Valentini, M A., Del Bello, B, Carmellini, M

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Cleavage of Bcl-2 in oxidant- and cisplatin-induced apoptosis of human melanoma cells by DEL BELLO, Barbara, VALENTINI, Marta A, ZUNINO, Franco, COMPORTI, Mario, MAELLARO, Emilia

“…Although the anti-apoptotic effect of Bcl-2 is well established, the role of Bcl-2 in tumour response to therapy and drug resistance is still unclear. The…”
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Different effects of interferon-[alpha] on melanoma cell lines: A study on telomerase reverse transcriptase, telomerase activity and apoptosis by Maellaro, E, Pacenti, L, B Del Bello, Valentini, M A

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Redox modulation of protein kinase/phosphatase balance in melanoma cells: the role of endogenous and gamma-glutamyltransferase-dependent H2O2 production by Pieri, Lisa, Dominici, Silvia, Del Bello, Barbara, Maellaro, Emilia, Comporti, Mario, Paolicchi, Aldo, Pompella, Alfonso

“…Alterations of protein kinase and protein phosphatase activities have been described in a number of tumors. Redox changes, such as in conditions of oxidant…”
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Cisplatin-induced apoptosis in melanoma cells: role of caspase-3 and caspase-7 in Apaf-1 proteolytic cleavage and in execution of the degradative phases by Del Bello, Barbara, Valentini, Marta A, Comporti, Mario, Maellaro, Emilia

“…Apoptosis protease-activating factor-1 (Apaf-1), which plays a central role in the formation of the apoptosome, is absent or poorly expressed (because of a…”
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Macrophage migration inhibitory factor protein and mRNA expression in cutaneous melanocytic tumours by MIRACCO, Clelia, DE NISI, Maria Caterina, MAELLARO, Emilia, DEL BELLO, Barbara, MASSI, Daniela, LUZI, Pietro, TOSI, Piero, ARCURI, Felice, COSCI, Elena, PACENTI, Lorenzo, TOSCANO, Marzia, LALINGA, Anna Vittoria, BIAGIOLI, Maurizio, RUBEGNI, Pietro, VATTI, Rosella

“…Macrophage migration inhibitory factor (MIF) is a widely expressed cytokine involved in various biological processes. Although MIF's functions in cancer have…”
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Protection by Ascorbate against Apoptosis of Thymocytes: Implications of Ascorbate-Induced Nonlethal Oxidative Stress and Poly(ADP-ribosyl)ation by Maellaro, E., Bello, B.Del, Comporti, M.

“…Apoptosis can be triggered in thymocytes with stimuli (6α-methylprednisolone, thapsigargin, and etoposide) acting by different mechanisms. In each of these…”
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Lipid peroxidation and antioxidant systems in the liver injury produced by glutathione depleting agents by Maellaro, E, Casini, A F, Del Bello, B, Comporti, M

“…The mechanisms of the liver damage produced by three glutathione (GSH) depleting agents, bromobenzene, allyl alcohol and diethylmaleate, was investigated. The…”
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Nonbiodegradable expanded polytetrafluoroethylene-covered stent implantation in porcine peripheral arteries : Histologic evaluation of vascular wall response compared with uncoated stents by SANGIORGI, Giuseppe, ARBUSTINI, Eloisa, LANZARINI, Paolo, DEL BELLO, Barbara, MAESTRI, Marcello, GASPARI, Annalisa, SOLCIA, Marco, VIRMANI, Renu, INGLESE, Luigi

“…To test the vascular wall response to an expanded polytetrafluoroethylene-covered stent, compared with conventional stenting, up to 6 months after deployment…”
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