Search Results - "Del Barrio, Laura"

Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lung infection while IL-1β is deleterious by Ceballos-Olvera, Ivonne, Sahoo, Manoranjan, Miller, Mark A, Del Barrio, Laura, Re, Fabio

“…Burkholderia pseudomallei is a Gram-negative bacterium that infects macrophages and other cell types and causes melioidosis. The interaction of B. pseudomallei…”
Get full text

Micro‐Topographies Induce Epigenetic Reprogramming and Quiescence in Human Mesenchymal Stem Cells by Vermeulen, Steven, Van Puyvelde, Bart, Bengtsson del Barrio, Laura, Almey, Ruben, Veer, Bernard K., Deforce, Dieter, Dhaenens, Maarten, de Boer, Jan

“…Biomaterials can control cell and nuclear morphology. Since the shape of the nucleus influences chromatin architecture, gene expression and cell identity,…”
Get full text

Prognostic Factor Utility of BAP1 Immunohistochemistry in Uveal Melanoma: A Single Center Study in Spain by Tabuenca Del Barrio, Laura, Nova-Camacho, Luiz Miguel, Zubicoa Enériz, Alicia, Martínez de Espronceda Ezquerro, Iñigo, Córdoba Iturriagagoitia, Alicia, Borque Rodríguez-Maimón, Enrique, García-Layana, Alfredo

“…Even today, the mortality rate for uveal melanoma (UM) remains very high. In our research, we sought to determine which pathological and clinical features were…”
Get full text

Metabolic Adaptation Establishes Disease Tolerance to Sepsis by Weis, Sebastian, Carlos, Ana Rita, Moita, Maria Raquel, Singh, Sumnima, Blankenhaus, Birte, Cardoso, Silvia, Larsen, Rasmus, Rebelo, Sofia, Schäuble, Sascha, Del Barrio, Laura, Mithieux, Gilles, Rajas, Fabienne, Lindig, Sandro, Bauer, Michael, Soares, Miguel P.

“…Sepsis is an often lethal syndrome resulting from maladaptive immune and metabolic responses to infection, compromising host homeostasis. Disease tolerance is…”
Get full text

Role of the Inflammasome, IL-1β, and IL-18 in Bacterial Infections by Re, Fabio, del Barrio, Laura, Ceballos-Olvera, Ivonne, Sahoo, Manoranjan

“…The inflammasome is an important innate immune pathway that regulates at least two host responses protective against infections: (1) secretion of the…”
Get full text

Renal control of disease tolerance to malaria by Ramos, Susana, Carlos, Ana Rita, Sundaram, Balamurugan, Jeney, Viktoria, Ribeiro, Ana, Gozzelino, Raffaella, Bank, Claudia, Gjini, Erida, Braza, Faouzi, Martins, Rui, Ademolue, Temitope Wilson, Blankenhaus, Birte, Gouveia, Zélia, Faísca, Pedro, Trujillo, Damian, Cardoso, Sílvia, Rebelo, Sofia, del Barrio, Laura, Zarjou, Abolfazl, Bolisetty, Subhashini, Agarwal, Anupam, Soares, Miguel P.

“…Malaria, the disease caused by Plasmodium spp. infection, remains a major global cause of morbidity and mortality. Host protection from malaria relies on…”
Get full text

Neutrophil elastase causes tissue damage that decreases host tolerance to lung infection with burkholderia species by Sahoo, Manoranjan, Del Barrio, Laura, Miller, Mark A, Re, Fabio

“…Two distinct defense strategies can protect the host from infection: resistance is the ability to destroy the infectious agent, and tolerance is the ability to…”
Get full text

Correlations between the NMR Lipoprotein Profile, APOE Genotype, and Cholesterol Efflux Capacity of Fasting Plasma from Cognitively Healthy Elderly Adults by de Rojas, Itziar, Del Barrio, Laura, Hernández, Isabel, Montrreal, Laura, García-González, Pablo, Marquié, Marta, Valero, Sergi, Cano, Amanda, Orellana, Adelina, Boada, Mercè, Mañes, Santos, Ruiz, Agustín

“…Cholesterol efflux capacity (CEC) is of interest given its potential relationship with several important clinical conditions including Alzheimer's disease. The…”
Get full text

Novel Multitarget Hybrid Compounds for the Treatment of Alzheimer's Disease by Michalska, Patrycja, Buendia, Izaskun, Del Barrio, Laura, Leon, Rafael

“…Alzheimer's disease (AD) is the most prevalent among the aging diseases known as neurodegenerative disorders. Drug design programs over the last two decades…”
Get more information

Guanosine protects human neuroblastoma SH-SY5Y cells against mitochondrial oxidative stress by inducing heme oxigenase-1 via PI3K/Akt/GSK-3β pathway by Dal-Cim, Tharine, Molz, Simone, Egea, Javier, Parada, Esther, Romero, Alejandro, Budni, Josiane, Martín de Saavedra, Maria D., Barrio, Laura del, Tasca, Carla I., López, Manuela G.

“…[Display omitted] ► Guanosine protects SH-SY5Y cells from oxidative damage induced by rotenone plus oligomycin. ► Guanosine promotes neuroprotection involves…”
Get full text

Production of anti-LPS IgM by B1a B cells depends on IL-1β and is protective against lung infection with Francisella tularensis LVS by del Barrio, Laura, Sahoo, Manoranjan, Lantier, Louis, Reynolds, Joseph M, Ceballos-Olvera, Ivonne, Re, Fabio

“…The role of IL-1β and IL-18 during lung infection with the gram-negative bacterium Francisella tularensis LVS has not been characterized in detail. Here, using…”
Get full text

N-Acylaminophenothiazines: Neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer’s disease by González-Muñoz, Gema C., Arce, Mariana P., López, Beatriz, Pérez, Concepción, Romero, Alejandro, Barrio, Laura del, Martín-de-Saavedra, María Dolores, Egea, Javier, León, Rafael, Villarroya, Mercedes, López, Manuela G., García, Antonio G., Conde, Santiago, Rodríguez-Franco, María Isabel

“…We have previously reported the multifunctional profile of N-(3-chloro-10H-phenothiazin-10-yl)-3-(dimethylamino)propanamide (1) as an effective neuroprotectant…”
Get full text

Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles by Samadi, Abdelouahid, Valderas, Carolina, Ríos, Cristóbal de los, Bastida, Agatha, Chioua, Mourad, González-Lafuente, Laura, Colmena, Inés, Gandía, Luis, Romero, Alejandro, Barrio, Laura del, Martín-de-Saavedra, María D., López, Manuela G., Villarroya, Mercedes, Marco-Contelles, José

“…The structures of tacrine, the 2-aminopyridine-3,5-dicarbonitrile precursors, and the new tacrine analogues. The synthesis, biological assessment, and…”
Get full text

Decreased painful visual acuity. Corynebacterium macginleyi blebitis-endophthalmitis infection by Tabuenca Del Barrio, L, Mozo Cuadrado, M, Borque Rodríguez-Maimón, E, Zubicoa Eneriz, A, Garralda Luquín, A

Get full text

ITH12410/SC058: A New Neuroprotective Compound with Potential in the Treatment of Alzheimer’s Disease by Romero, Alejandro, Egea, Javier, González-Muñoz, Gema C, Martı́n de Saavedra, Ma Dolores, del Barrio, Laura, Rodríguez-Franco, María Isabel, Conde, Santiago, López, Manuela G, Villarroya, Mercedes, de los Ríos, Cristóbal

“…The neuroprotective profile of the dibenzothiadiazepine ITH12410/SC058 (2-chloro-5,6-dihydro-5,6-diacetyldibenzo[b,f][1,4,5]thiadiazepine) against several…”
Get full text

Participation of calbindin-D28K in nociception: results from calbindin-D28K knockout mice by Egea, Javier, Malmierca, Eduardo, Rosa, Angelo O., del Barrio, Laura, Negredo, Pilar, Nuñez, Angel, López, Manuela G.

“…Since calbindin-D 28K (CB-D 28K )-positive neurons have been related to nociceptive sensory processing, we have hypothesized that altered CB-D 28K expression…”
Get full text

Stellate cell dynamics in progression and regression of hepatic fibrosis by del Barrio, Laura Almale, Scott, Emma A.H., Bjerre, Frederik Adam, Terkelsen, Mike, Ravnskjaer, Kim

Get full text

Bilateral Drug-Induced Uveitis and Epiretinal Membrane during the Treatment of a Metastatic Cutaneous Melanoma by Mozo Cuadrado, Marcos, Tabuenca Del Barrio, Laura, Compains Silva, Esther

“…Purpose: To report the case of a drug-induced uveitis during the treatment of a metastatic cutaneous melanoma. Case report: A 75-year-old female treated with…”
Get full text

Nrf2 participates in depressive disorders through an anti-inflammatory mechanism by Martín-de-Saavedra, María Dolores, Budni, Josiane, Cunha, Mauricio P, Gómez-Rangel, Vanessa, Lorrio, Silvia, del Barrio, Laura, Lastres-Becker, Isabel, Parada, Esther, Tordera, Rosa María, Rodrigues, Ana Lùcia S, Cuadrado, Antonio, López, Manuela G

“…Summary A causative relationship between inflammation and depression is gradually gaining consistency. Because Nrf2 participates in inflammation, we…”
Get full text

Poststress treatment with PNU282987 can rescue SH-SY5Y cells undergoing apoptosis via α7 nicotinic receptors linked to a Jak2/Akt/HO-1 signaling pathway by Parada, Esther, Egea, Javier, Romero, Alejandro, del Barrio, Laura, García, Antonio G., López, Manuela G.

“…Most neuroprotection studies with nicotinic agonists have shown efficacy when given before the stressor. Here we have investigated whether the α7 nicotinic…”
Get full text