Search Results - "Del Valle, Juan R."

Chemistry and Biology of the Aeruginosin Family of Serine Protease Inhibitors by Ersmark, Karolina, Del Valle, Juan R, Hanessian, Stephen

“…The aeruginosins have been isolated from marine sponges and cyanobacterial waterblooms, sources that are phylogenetically distinct and the bodies of water are…”
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Clarifying the translational potential of B-I09 by Del Valle, Juan R., Betts, Brian C., Yu, Xue-Zhong, Janssens, Sophie, Lambrecht, Bart N., Simon, M. Celeste, Hu, Chih-Chi Andrew

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Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells by Tang, Chih-Hang Anthony, Zundell, Joseph A, Ranatunga, Sujeewa, Lin, Cindy, Nefedova, Yulia, Del Valle, Juan R, Hu, Chih-Chi Andrew

“…Endoplasmic reticulum (ER) stress responses through the IRE-1/XBP-1 pathway are required for the function of STING (TMEM173), an ER-resident transmembrane…”
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Late-Stage Sidechain-to-Backbone Macrocyclization of N‑Amino Peptides by Rathman, Benjamin M, Del Valle, Juan R

“…Cysteine-containing N-amino peptides undergo chemoselective reactions with haloaldehydes to afford ethylene-bridged cyclic peptides. This bis-alkylation…”
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Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival by Tang, Chih-Hang Anthony, Ranatunga, Sujeewa, Kriss, Crystina L, Cubitt, Christopher L, Tao, Jianguo, Pinilla-Ibarz, Javier A, Del Valle, Juan R, Hu, Chih-Chi Andrew

“…Activation of the ER stress response is associated with malignant progression of B cell chronic lymphocytic leukemia (CLL). We developed a murine CLL model…”
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Total synthesis and chemical stability of pseudouridimycin by Cain, Christopher F, Scott, Aaron M, Sarnowski, Matthew P, Del Valle, Juan R

“…We report the chemical synthesis of pseudouridimycin (1), an antimicrobial natural product that potently and selectively inhibits bacterial RNA polymerase…”
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Peptide N‐Amination Supports β‐Sheet Conformations by Sarnowski, Matthew P., Kang, Chang Won, Elbatrawi, Yassin M., Wojtas, Lukasz, Del Valle, Juan R.

“…The conformational heterogeneity of backbone N‐substituted peptides limits their ability to adopt stable secondary structures. Herein, we describe a practical…”
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Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization by Tang, Chih-Hang Anthony, Chang, Shiun, Paton, Adrienne W, Paton, James C, Gabrilovich, Dmitry I, Ploegh, Hidde L, Del Valle, Juan R, Hu, Chih-Chi Andrew

“…To relieve endoplasmic reticulum (ER) stress, IRE1 splices XBP1 messenger RNA (mRNA) or engages regulated IRE1-dependent decay (RIDD) of other mRNAs. Upon XBP1…”
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STING regulates BCR signaling in normal and malignant B cells by Tang, Chih-Hang Anthony, Lee, Avery C., Chang, Shiun, Xu, Qin, Shao, Andong, Lo, Yun, Spalek, Walker T., Pinilla-Ibarz, Javier A., Del Valle, Juan R., Hu, Chih-Chi Andrew

“…STING is an endoplasmic reticulum (ER)-resident protein critical for sensing cytoplasmic DNA and promoting the production of type I interferons; however, the…”
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Synthesis of Novel Tricyclic Chromenone-Based Inhibitors of IRE‑1 RNase Activity by Ranatunga, Sujeewa, Tang, Chih-Hang Anthony, Kang, Chang Won, Kriss, Crystina L, Kloppenburg, Bernhard J, Hu, Chih-Chi Andrew, Del Valle, Juan R

“…Inositol-requiring enzyme 1 (IRE-1) is a kinase/RNase ER stress sensor that is activated in response to excessive accumulation of unfolded proteins, hypoxic…”
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Synthetic studies toward eleganine A by Cain, Christopher F., Howard, Evan H., Goodwin, Justin A., Valle, Juan R. Del

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Inhibition of Human Dendritic Cell ER Stress Response Reduces T Cell Alloreactivity Yet Spares Donor Anti-tumor Immunity by Betts, Brian C, Locke, Frederick L, Sagatys, Elizabeth M, Pidala, Joseph, Walton, Kelly, Menges, Meghan, Reff, Jordan, Saha, Asim, Djeu, Julie Y, Kiluk, John V, Lee, Marie C, Kim, Jongphil, Kang, Chang Won, Tang, Chih-Hang, Frieling, Jeremy, Lynch, Conor C, List, Alan, Rodriguez, Paulo C, Blazar, Bruce R, Conejo-Garcia, Jose R, Del Valle, Juan R, Hu, Chih-Chi, Anasetti, Claudio

“…Acute graft- vs. -host disease (GVHD) is an important cause of morbidity and death after allogeneic hematopoietic cell transplantation (HCT). We identify a new…”
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Synthesis, derivatization, and conformational scanning of peptides containing N-Aminoglycine by Starnes, Syrah K, Del Valle, Juan R

“…N-alkylated glycine residues are the main constituent of peptoids and peptoid-peptide hybrids that are employed across the biomedical and materials sciences…”
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Synthesis of Boc-protected bicycloproline by Ranatunga, Sujeewa, Valle, Juan R. Del

“…The synthesis of a highly constrained quaternary carbocyclic α-amino acid, (+)- N-Boc-bicycloproline, has been achieved starting from sodium…”
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Beyond N‑Alkylation: Synthesis, Structure, and Function of N‑Amino Peptides by Angera, Isaac J., Wright, Madison M., Del Valle, Juan R.

“…Conspectus The growing list of physiologically important protein–protein interactions (PPIs) has amplified the need for compounds to target topologically…”
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Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice by Schutt, Steven D., Wu, Yongxia, Tang, Chih-Hang Anthony, Bastian, David, Nguyen, Hung, Sofi, M. Hanief, Zhang, MengMeng, Liu, Chen, Helke, Kris, Wilson, Carole, Schnapp, Lynn M., Del Valle, Juan R., Hu, Chih-Chi Andrew, Yu, Xue-Zhong

“…Hematopoietic stem cell transplantation (HCT) is a curative procedure for hematological malignancies, but chronic graft-versus-host disease (cGVHD) remains a…”
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Total Synthesis of Marformycins A and D by Anwar, Avraz F., Elbatrawi, Yassin M., Degen, David, Ebright, Richard H., Del Valle, Juan R.

“…We report the synthesis of the antimicrobial cyclodepsipeptides marformycin A (1) and marformycin D (2) using a solid-phase approach. A scalable solution-phase…”
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IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers by Xie, Hong, Tang, Chih-Hang Anthony, Song, Jun H, Mancuso, Anthony, Del Valle, Juan R, Cao, Jin, Xiang, Yan, Dang, Chi V, Lan, Roy, Sanchez, Danielle J, Keith, Brian, Hu, Chih-Chi Andrew, Simon, M Celeste

“…Myc activation is a primary oncogenic event in many human cancers; however, these transcription factors are difficult to inhibit pharmacologically, suggesting…”
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N‑Aminoglycine and Its Derivatives Stabilize PPII Secondary Structure by Rajewski, Benjamin H., Wright, Madison M., Gerrein, Taylor A., Del Valle, Juan R.

“…The identification of unnatural residues that stabilize polyproline type 2 (PPII) folds can aid in the design of peptidomimetics targeting PPII-binding…”
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Synthetic Studies in the Intramolecular Carbocyclization of N-Acyloxyiminium Ions. Stereoelectronic and Steric Implications of Nucleophilic Alkene, Alkyne, and Allene Tethers by Hanessian, Stephen, Tremblay, Martin, Marzi, Mauro, Del Valle, Juan R

“…N-Acyloxyiminium ions generated from 4-substituted l-pyroglutamic esters with 4-(3-butenyl), 4-(3-butynyl), 4-(3-cinnamylmethyl), and 4-allenic tethers undergo…”
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