Search Results - "Dekkers, Dick"

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC by Raj, V. Stalin, Mou, Huihui, Smits, Saskia L., Dekkers, Dick H. W., Müller, Marcel A., Dijkman, Ronald, Muth, Doreen, Demmers, Jeroen A. A., Zaki, Ali, Fouchier, Ron A. M., Thiel, Volker, Drosten, Christian, Rottier, Peter J. M., Osterhaus, Albert D. M. E., Bosch, Berend Jan, Haagmans, Bart L.

“…Human coronavirus-EMC (hCoV-EMC) is a new coronavirus that has killed around half of the few humans infected so far; this study now identifies DPP4 as the…”
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Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes by Engelen, Erik, Akinci, Umut, Bryne, Jan Christian, Hou, Jun, Gontan, Cristina, Moen, Maaike, Szumska, Dorota, Kockx, Christel, van IJcken, Wilfred, Dekkers, Dick H W, Demmers, Jeroen, Rijkers, Erik-Jan, Bhattacharya, Shoumo, Philipsen, Sjaak, Pevny, Larysa H, Grosveld, Frank G, Rottier, Robbert J, Lenhard, Boris, Poot, Raymond A

“…Raymond Poot and colleagues report that Chd7, a chromatin remodeler associated with CHARGE syndrome, and Sox2, a transcription factor associated with an…”
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UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair by Schwertman, Petra, Lagarou, Anna, Dekkers, Dick H W, Raams, Anja, van der Hoek, Adriana C, Laffeber, Charlie, Hoeijmakers, Jan H J, Demmers, Jeroen A A, Fousteri, Maria, Vermeulen, Wim, Marteijn, Jurgen A

“…Jurgen Marteijn, Wim Vermeulen and colleagues report proteomic identification of UVSSA in a UV-induced protein complex implicated in UV-sensitive syndrome…”
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Nucleotide Biosynthetic Enzyme GMP Synthase Is a TRIM21-Controlled Relay of p53 Stabilization by Reddy, B. Ashok, van der Knaap, Jan A., Bot, Alice G.M., Mohd-Sarip, Adone, Dekkers, Dick H.W., Timmermans, Mieke A., Martens, John W.M., Demmers, Jeroen A.A., Verrijzer, C. Peter

“…Nucleotide biosynthesis is fundamental to normal cell proliferation as well as to oncogenesis. Tumor suppressor p53, which prevents aberrant cell…”
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Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration by van den Berg, Debbie L.C., Azzarelli, Roberta, Oishi, Koji, Martynoga, Ben, Urbán, Noelia, Dekkers, Dick H.W., Demmers, Jeroen A., Guillemot, François

“…Mutations in NIPBL are the most frequent cause of Cornelia de Lange syndrome (CdLS), a developmental disorder encompassing several neurological defects,…”
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Mediator complex interaction partners organize the transcriptional network that defines neural stem cells by Quevedo, Marti, Meert, Lize, Dekker, Mike R., Dekkers, Dick H. W., Brandsma, Johannes H., van den Berg, Debbie L. C., Ozgür, Zeliha, van IJcken, Wilfred F. J., Demmers, Jeroen, Fornerod, Maarten, Poot, Raymond A.

“…The Mediator complex regulates transcription by connecting enhancers to promoters. High Mediator binding density defines super enhancers, which regulate…”
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BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1 by Drost, Rinske, Dhillon, Kiranjit K, van der Gulden, Hanneke, van der Heijden, Ingrid, Brandsma, Inger, Cruz, Cristina, Chondronasiou, Dafni, Castroviejo-Bermejo, Marta, Boon, Ute, Schut, Eva, van der Burg, Eline, Wientjens, Ellen, Pieterse, Mark, Klijn, Christiaan, Klarenbeek, Sjoerd, Loayza-Puch, Fabricio, Elkon, Ran, van Deemter, Liesbeth, Rottenberg, Sven, van de Ven, Marieke, Dekkers, Dick H W, Demmers, Jeroen A A, van Gent, Dik C, Agami, Reuven, Balmaña, Judith, Serra, Violeta, Taniguchi, Toshiyasu, Bouwman, Peter, Jonkers, Jos

“…Heterozygous germline mutations in breast cancer 1 (BRCA1) strongly predispose women to breast cancer. BRCA1 plays an important role in DNA double-strand break…”
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CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment by Smits, Daphne J., Dekker, Jordy, Schot, Rachel, Tabarki, Brahim, Alhashem, Amal, Demmers, Jeroen A. A., Dekkers, Dick H. W., Romito, Antonio, van der Spek, Peter J., van Ham, Tjakko J., Bertoli-Avella, Aida M., Mancini, Grazia M. S.

“…CLEC16A is a membrane-associated C-type lectin protein that functions as a E3-ubiquitin ligase. CLEC16A regulates autophagy and mitophagy, and reportedly…”
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Identification of the (Pro)renin Receptor as a Novel Regulator of Low-Density Lipoprotein Metabolism by Lu, Xifeng, Meima, Marcel E, Nelson, Jessica K, Sorrentino, Vincenzo, Loregger, Anke, Scheij, Saskia, Dekkers, Dick H.W, Mulder, Monique T, Demmers, Jeroen A.A, M-Dallinga-Thie, Geesje, Zelcer, Noam, Danser, A.H Jan

“…RATIONALE:The (pro)renin receptor ([P]RR) interacts with (pro)renin at concentrations that are >1000× higher than observed under (patho)physiological…”
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Caldendrin and myosin V regulate synaptic spine apparatus localization via ER stabilization in dendritic spines by Konietzny, Anja, Grendel, Jasper, Kadek, Alan, Bucher, Michael, Han, Yuhao, Hertrich, Nathalie, Dekkers, Dick H W, Demmers, Jeroen A A, Grünewald, Kay, Uetrecht, Charlotte, Mikhaylova, Marina

“…Excitatory synapses of principal hippocampal neurons are frequently located on dendritic spines. The dynamic strengthening or weakening of individual inputs…”
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In vivo analysis reveals that ATP-hydrolysis couples remodeling to SWI/SNF release from chromatin by Tilly, Ben C, Chalkley, Gillian E, van der Knaap, Jan A, Moshkin, Yuri M, Kan, Tsung Wai, Dekkers, Dick HW, Demmers, Jeroen AA, Verrijzer, C Peter

“…ATP-dependent chromatin remodelers control the accessibility of genomic DNA through nucleosome mobilization. However, the dynamics of genome exploration by…”
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Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disorders by Estruch, Sara B, Graham, Sarah A, Quevedo, Martí, Vino, Arianna, Dekkers, Dick H W, Deriziotis, Pelagia, Sollis, Elliot, Demmers, Jeroen, Poot, Raymond A, Fisher, Simon E

“…Abstract FOXP transcription factors play important roles in neurodevelopment, but little is known about how their transcriptional activity is regulated. FOXP…”
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Characterization of the TBR1 interactome: variants associated with neurodevelopmental disorders disrupt novel protein interactions by Sollis, Elliot, den Hoed, Joery, Quevedo, Marti, Estruch, Sara B, Vino, Arianna, Dekkers, Dick H W, Demmers, Jeroen A A, Poot, Raymond, Deriziotis, Pelagia, Fisher, Simon E

“…Abstract TBR1 is a neuron-specific transcription factor involved in brain development and implicated in a neurodevelopmental disorder (NDD) combining features…”
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Myosin V regulates synaptopodin clustering and localization in the dendrites of hippocampal neurons by Konietzny, Anja, González-Gallego, Judit, Bär, Julia, Perez-Alvarez, Alberto, Drakew, Alexander, Demmers, Jeroen A A, Dekkers, Dick H W, Hammer, 3rd, John A, Frotscher, Michael, Oertner, Thomas G, Wagner, Wolfgang, Kneussel, Matthias, Mikhaylova, Marina

“…The spine apparatus (SA) is an endoplasmic reticulum-related organelle that is present in a subset of dendritic spines in cortical and pyramidal neurons, and…”
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HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis by Brandsma, Inger, Sato, Koichi, van Rossum-Fikkert, Sari E., van Vliet, Nicole, Sleddens, Esther, Reuter, Marcel, Odijk, Hanny, van den Tempel, Nathalie, Dekkers, Dick H.W., Bezstarosti, Karel, Demmers, Jeroen A.A., Maas, Alex, Lebbink, Joyce, Wyman, Claire, Essers, Jeroen, van Gent, Dik C., Baarends, Willy M., Knipscheer, Puck, Kanaar, Roland, Zelensky, Alex N.

“…The tumor suppressor BRCA2 is essential for homologous recombination (HR), replication fork stability, and DNA interstrand crosslink repair in vertebrates. We…”
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Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation by van Sluis, Marjolein, Yu, Qing, van der Woude, Melanie, Gonzalo-Hansen, Camila, Dealy, Shannon C., Janssens, Roel C., Somsen, Hedda B., Ramadhin, Anisha R., Dekkers, Dick H. W., Wienecke, Hannah Lena, Demmers, Joris J. P. G., Raams, Anja, Davó-Martínez, Carlota, Llerena Schiffmacher, Diana A., van Toorn, Marvin, Häckes, David, Thijssen, Karen L., Zhou, Di, Lammers, Judith G., Pines, Alex, Vermeulen, Wim, Pothof, Joris, Demmers, Jeroen A. A., van den Berg, Debbie L. C., Lans, Hannes, Marteijn, Jurgen A.

“…DNA–protein crosslinks (DPCs) arise from enzymatic intermediates, metabolism or chemicals like chemotherapeutics. DPCs are highly cytotoxic as they impede…”
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Prorenin Induces Intracellular Signaling in Cardiomyocytes Independently of Angiotensin II by Saris, Jasper J, ’t Hoen, Peter A.C, Garrelds, Ingrid M, Dekkers, Dick H.W, den Dunnen, Johan T, Lamers, Jos M.J, Danser, A H. Jan

“…Tissue accumulation of circulating prorenin results in angiotensin generation, but could also, through binding to the recently cloned (pro)renin receptor, lead…”
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Elevated Plasma Cardiac Troponin T Levels Caused by Skeletal Muscle Damage in Pompe Disease by Wens, Stephan C.A, Schaaf, Gerben J, Michels, Michelle, Kruijshaar, Michelle E, van Gestel, Tom J.M, in ‘t Groen, Stijn, Pijnenburg, Joon, Dekkers, Dick H.W, Demmers, Jeroen A.A, Verdijk, Lex B, Brusse, Esther, van Schaik, Ron H.N, van der Ploeg, Ans T, van Doorn, Pieter A, Pijnappel, W.W.M Pim

“…BACKGROUND—Elevated plasma cardiac troponin T (cTnT) levels in patients with neuromuscular disorders may erroneously lead to the diagnosis of acute myocardial…”
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Proteins that bind regulatory regions identified by histone modification chromatin immunoprecipitations and mass spectrometry by Engelen, Erik, Brandsma, Johannes H., Moen, Maaike J., Signorile, Luca, Dekkers, Dick H. W., Demmers, Jeroen, Kockx, Christel E. M., Ozgür, Zehila, van IJcken, Wilfred F. J., van den Berg, Debbie L. C., Poot, Raymond A.

“…The locations of transcriptional enhancers and promoters were recently mapped in many mammalian cell types. Proteins that bind those regulatory regions can…”
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Quantitative Proteomics Reveals Extensive Changes in the Ubiquitinome after Perturbation of the Proteasome by Targeted dsRNA-Mediated Subunit Knockdown in Drosophila by Sap, Karen A, Bezstarosti, Karel, Dekkers, Dick H. W, Voets, Olaf, Demmers, Jeroen A. A

“…The ubiquitin–proteasome system (UPS), a highly regulated mechanism including the active marking of proteins by ubiquitin to be degraded, is critical in…”
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