Search Results - "Dekkers, Bart G.J"

Phenotype modulation of airway smooth muscle in asthma by Wright, David B, Trian, Thomas, Siddiqui, Sana, Pascoe, Chris D, Johnson, Jill R, Dekkers, Bart G.J, Dakshinamurti, Shyamala, Bagchi, Rushita, Burgess, Janette K, Kanabar, Varsha, Ojo, Oluwaseun O

“…Abstract The biological responses of airway smooth muscle (ASM) are diverse, in part due to ASM phenotype plasticity. ASM phenotype plasticity refers to the…”
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Muscarinic receptors on airway mesenchymal cells: Novel findings for an ancient target by Meurs, Herman, Dekkers, Bart G.J, Maarsingh, Harm, Halayko, Andrew J, Zaagsma, Johan, Gosens, Reinoud

“…Abstract Since ancient times, anticholinergics have been used as a bronchodilator therapy for obstructive lung diseases. Targets of these drugs are…”
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Poor solubility and stability of rapamycin in aqueous environments by van der Wagt, Marijke A.J., Touw, Daan J., Dekkers, Bart G.J.

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Integrins: therapeutic targets in airway hyperresponsiveness and remodelling? by Wright, David B, Meurs, Herman, Dekkers, Bart G.J

“…Highlights • Current therapy is ineffective for the treatment of airway remodelling in asthma and COPD. • Changes in the environment of ASM may promote and…”
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Relevance of the drug–drug interactions between lidocaine and the pharmacokinetic enhancers ritonavir and cobicistat by Dekkers, Bart G.J, Bierman, Wouter F.W, Touw, Daan J, Alffenaar, Jan-Willem C

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Distinct PKA and Epac compartmentalization in airway function and plasticity by DEKKERS, Bart GJ, RACKE, Kurt, SCHMIDT, Martina

“…Asthma and chronic obstructive pulmonary disease (COPD) are obstructive lung diseases characterized by airway obstruction, airway inflammation and airway…”
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Basement membranes in obstructive pulmonary diseases by Dekkers, Bart G.J., Saad, Shehab I., van Spelde, Leah J., Burgess, Janette K.

“…•Basement membrane composition is changed in the airways of patients with obstructive airway diseases.•Basement membrane changes are linked to disease…”
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Pharmacology of airway smooth muscle proliferation by Gosens, Reinoud, Roscioni, Sara S., Dekkers, Bart G.J., Pera, Tonio, Schmidt, Martina, Schaafsma, Dedmer, Zaagsma, Johan, Meurs, Herman

“…Airway smooth muscle thickening is a pathological feature that contributes significantly to airflow limitation and airway hyperresponsiveness in asthma…”
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Functional phenotype of airway myocytes from asthmatic airways by Wright, David B, Trian, Thomas, Siddiqui, Sana, Pascoe, Chris D, Ojo, Oluwaseun O, Johnson, Jill R, Dekkers, Bart G.J, Dakshinamurti, Shyamala, Bagchi, Rushita, Burgess, Janette K, Kanabar, Varsha

“…Abstract In asthma, the airway smooth muscle (ASM) cell plays a central role in disease pathogenesis through cellular changes which may impact on its…”
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Amanitin intoxication: effects of therapies on clinical outcomes - a review of 40 years of reported cases by Tan, Jia Lin, Stam, Janine, van den Berg, Aad P., van Rheenen, Patrick F., Dekkers, Bart G. J., Touw, Daan J.

“…Amanita phalloides poisoning causes severe liver damage which may be potentially fatal. Several treatments are available, but their effectiveness has not been…”
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Authors' reply to amanita intoxication by Dekkers, Bart G. J., Touw, Daan J.

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LC-MS/MS for Therapeutic Drug Monitoring of anti-infective drugs by Veringa, Anette, Sturkenboom, Marieke G.G., Dekkers, Bart G.J., Koster, Remco A., Roberts, Jason A., Peloquin, Charles A., Touw, Daan J., Alffenaar, Jan-Willem C.

“…•TDM of anti-infective drugs plays an important role in treatment optimisation of infectious diseases. TDM is mostly performed in blood, serum or plasma, but…”
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Effects of interrupting the enterohepatic circulation in amatoxin intoxications by Varekamp, Jurriaan, Tan, Jia Lin, Stam, Janine, van den Berg, Aad P, van Rheenen, Patrick F, Touw, Daan J, Dekkers, Bart G J

“…Interruption of the enterohepatic circulation is regarded as an effective way to treat patients with amatoxin poisoning. Nonetheless, its effectiveness has not…”
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Laminin α4 contributes to airway remodeling and inflammation in asthma by Prabhala, Pavan, Wright, David B, Robbe, Patricia, Bitter, Catrin, Pera, Tonio, Ten Hacken, Nick H T, van den Berge, Maarten, Timens, Wim, Meurs, Herman, Dekkers, Bart G J

“…Airway inflammation and remodeling are characteristic features of asthma, with both contributing to airway hyperresponsiveness (AHR) and lung function…”
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Managing intoxications with nicotine-containing e-liquids by Henstra, Charlotte, Dekkers, Bart G J, Olgers, Tycho J, Ter Maaten, Jan C, Touw, Daan J

“…Nicotine is an addictive and poisonous agent. The recent development of e-cigarettes has caused a new demand for highly concentrated nicotine-containing…”
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Relevance of the drug-drug interactions between lidocaine and the pharmacokinetic enhancers ritonavir and cobicistat by Dekkers, Bart G J, Bierman, Wouter F W, Touw, Daan J, Alffenaar, Jan-Willem C

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Reduced moxifloxacin exposure in patients with tuberculosis and diabetes by Dekkers, Bart G J, Bolhuis, Mathieu S, Ter Beek, Lies, de Lange, Wiel C M, van der Werf, Tjip S, Alffenaar, Jan-Willem C, Akkerman, Onno W

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Therapeutic Drug Monitoring of Posaconazole: an Update by Dekkers, Bart G. J., Bakker, Martijn, van der Elst, Kim C. M., Sturkenboom, Marieke G. G., Veringa, Anette, Span, Lambert F. R., Alffenaar, Jan-Willem C.

“…Posaconazole is a second-generation triazole agent with a potent and broad antifungal activity. In addition to the oral suspension, a delayed-release tablet…”
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Insulin-Induced Laminin Expression Promotes a Hypercontractile Airway Smooth Muscle Phenotype by Dekkers, Bart G. J, Schaafsma, Dedmer, Tran, Thai, Zaagsma, Johan, Meurs, Herman

“…Airway smooth muscle (ASM) plays a key role in the development of airway hyperresponsiveness and remodeling in asthma, which may involve maturation of ASM…”
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Unexpected Amanita phalloides -Induced Hematotoxicity-Results from a Retrospective Study by Visser, Miranda, Hof, Willemien F J, Broek, Astrid M, van Hoek, Amanda, de Jong, Joyce J, Touw, Daan J, Dekkers, Bart G J

“…poisoning is a serious health problem with a mortality rate of 10-40%. Poisonings are characterized by severe liver and kidney toxicity. The effect of…”
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