Search Results - "Dekker, Simone E."

Early single-dose exosome treatment improves neurologic outcomes in a 7-day swine model of traumatic brain injury and hemorrhagic shock by Williams, Aaron M., Wu, Zhenyu, Bhatti, Umar F., Biesterveld, Ben E., Kemp, Michael T., Wakam, Glenn K., Vercruysse, Claire A., Chtraklin, Kiril, Siddiqui, Ali Z., Pickell, Zachary, Dekker, Simone E., Tian, Yuzi, Liu, Baoling, Li, Yongqing, Buller, Benjamin, Alam, Hasan B.

“…Early single-dose treatment with human mesenchymal stem cell-derived exosomes promotes neuroprotection and promotes blood-brain barrier integrity in models of…”
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Early Resuscitation with Fresh Frozen Plasma for Traumatic Brain Injury Combined with Hemorrhagic Shock Improves Neurologic Recovery by Halaweish, Ihab, MD, Bambakidis, Ted, MS, He, Wei, MD, Linzel, Durk, MD, Chang, Zhigang, MD, Srinivasan, Ashok, MD, Dekker, Simone E., BSc, Liu, Baoling, MD, Li, Yongqing, MD, PhD, Alam, Hasan B., MD, FACS

“…Background We have shown that early administration of fresh frozen plasma (FFP) reduces the size of brain lesions 6 hours after injury in a large animal model…”
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Intracranial facial nerve schwannomas: current management and review of the literature by Xu, Feng, MD, PhD, Pan, Sida, MD, Bambakidis, Nicholas C., MD

“…Abstract Facial nerve schwannomas are rare, benign, nerve-sheath tumors. They can occur in any segment of the facial nerve, and often clinically and…”
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The Retrolabyrinthine Presigmoid Approach to the Anterior Cerebellopontine Region: Expanding the Limits of Trautmann Triangle by Alonso, Fernando, Dekker, Simone E., Wright, James, Wright, Christina, Alonso, Andrea, Carmody, Margaret, Tubbs, R. Shane, Bambakidis, Nicholas C.

“…The anatomic area exposed through exposure of Trautmann triangle may not be sufficient. We studied the additional exposure provided by skeletonizing the…”
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Relationship between tissue perfusion and coagulopathy in traumatic brain injury by Dekker, Simone E., MD, Duvekot, Anne, MD, de Vries, Hielke-Martijn, Bsc, Geeraedts, Leo M.G., MD, PhD, Peerdeman, Saskia M., MD, PhD, de Waard, Monique C., PhD, Boer, Christa, PhD, Schober, Patrick, MD, PhD

“…Abstract Background Traumatic brain injury (TBI) related coagulopathy appears to be most prevalent in patients with tissue hypoperfusion, but evidence for this…”
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Normal saline influences coagulation and endothelial function after traumatic brain injury and hemorrhagic shock in pigs by Dekker, Simone E., BSc, Sillesen, Martin, MD, Bambakidis, Ted, MSc, Jin, Guang, MD, PhD, Liu, Baoling, MD, Boer, Christa, PhD, Johansson, Pär I., MD, DMSc, MPA, Halaweish, Ihab, MD, Maxwell, Jake, Alam, Hasan B., MD

“…Background Traumatic brain injury (TBI) and hemorrhagic shock (HS) are the leading causes of trauma-related deaths. These insults disrupt coagulation and…”
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Development of a novel neuroprotective strategy: Combined treatment with hypothermia and valproic acid improves survival in hypoxic hippocampal cells by Jin, Guang, MD, PhD, Liu, Baoling, MD, You, Zerong, PhD, Bambakidis, Ted, MS, Dekker, Simone E., BS, Maxwell, Jake, Halaweish, Ihab, MD, Linzel, Durk, MD, Alam, Hasan B., MD

“…Background Therapeutic hypothermia and histone deacetylase inhibitors, such as valproic acid (VPA), independently have been shown to have neuroprotective…”
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Hypothermia and valproic acid activate prosurvival pathways after hemorrhage by Bambakidis, Ted, MSc, Dekker, Simone E., BSc, Liu, Baoling, MD, Maxwell, Jake, Chtraklin, Kiril, DVM, Linzel, Durk, MD, Li, Yongqing, MD, PhD, Alam, Hasan B., MD

“…Abstract Background Therapeutic hypothermia (hypo) and valproic acid (VPA, a histone deacetylase inhibitor) have independently been shown to be protective in…”
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Treatment with a histone deacetylase inhibitor, valproic acid, is associated with increased platelet activation in a large animal model of traumatic brain injury and hemorrhagic shock by Dekker, Simone E., BSc, Sillesen, Martin, MD, Bambakidis, Ted, MSc, Andjelkovic, Anuska V., MD, PhD, Jin, Guang, MD, PhD, Liu, Baoling, MD, Boer, Christa, PhD, Johansson, Pär I., MD, Dmsc, MPA, Linzel, Durk, MD, Halaweish, Ihab, MD, Alam, Hasan B., MD

“…Abstract Background We have previously shown that resuscitation with fresh frozen plasma (FFP) in a large animal model of traumatic brain injury (TBI) and…”
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SOHO State of the Art Updates and Next Questions: Measurable Residual Disease in Acute Lymphoblastic Leukemia - Optimization and Innovation in 2022 and Beyond by Dekker, Simone E., Leonard, Jessica, Muffly, Lori

“…Measurable residual disease (MRD) is an established component of acute lymphoblastic leukemia (ALL) management in both children and adults. Society guidelines…”
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Treatment and Prevention of Acute Hepatitis B Virus by Dekker, Simone E., Green, Ellen W., Ahn, Joseph

“…This article reviews the incidence of acute hepatitis B virus (HBV) infection, its clinical course, strategies to prevent acute HBV infection in susceptible…”
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Early single-dose treatment with exosomes provides neuroprotection and improves blood-brain barrier integrity in swine model of traumatic brain injury and hemorrhagic shock by Williams, Aaron M., Bhatti, Umar F., Brown, Jordana F., Biesterveld, Ben E., Kathawate, Ranganath G., Graham, Nathan J., Chtraklin, Kiril, Siddiqui, Ali Z., Dekker, Simone E., Andjelkovic, Anuska, Higgins, Gerald A., Buller, Benjamin, Alam, Hasan B.

“…Administration of human mesenchymal stem cell (MSC)-derived exosomes can enhance neurorestoration in models of traumatic brain injury (TBI) and hemorrhagic…”
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Challenging clinical scenarios for therapeutic anticoagulation: A practical approach by Martens, Kylee L., Dekker, Simone E., Crowe, Megan, DeLoughery, Thomas G., Shatzel, Joseph J.

“…Therapeutic anticoagulation remains a fundamental backbone in the treatment and prevention of venous thromboembolism. However, while modern therapies are…”
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Comparison of Materials Used for 3D-Printing Temporal Bone Models to Simulate Surgical Dissection by McMillan, Alexandra, Kocharyan, Armine, Dekker, Simone E., Kikano, Elias George, Garg, Anisha, Huang, Victoria W., Moon, Nicholas, Cooke, Malcolm, Mowry, Sarah E.

“…Objective: To identify 3D-printed temporal bone (TB) models that most accurately recreate cortical mastoidectomy for use as a training tool by comparison of…”
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Early treatment with exosomes following traumatic brain injury and hemorrhagic shock in a swine model promotes transcriptional changes associated with neuroprotection by Williams, Aaron M., Higgins, Gerald A., Bhatti, Umar F., Biesterveld, Ben E., Dekker, Simone E., Kathawate, Ranganath G., Tian, Yuzi, Wu, Zhenyu, Kemp, Michael T., Wakam, Glenn K., Liu, Baoling, Li, Yongqing, Buller, Benjamin, Alam, Hasan B.

“…We have shown that administration of mesenchymal stem cell-derived exosomes (single dose given within 1 hour) in models of traumatic brain injury (TBI) and…”
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Early Treatment With a Single Dose of Mesenchymal Stem Cell Derived Extracellular Vesicles Modulates the Brain Transcriptome to Create Neuroprotective Changes in a Porcine Model of Traumatic Brain Injury and Hemorrhagic Shock by Bambakidis, Ted, Dekker, Simone E., Williams, Aaron M., Biesterveld, Ben E., Bhatti, Umar F., Liu, Baoling, Li, Yongqing, Pickell, Zachary, Buller, Benjamin, Alam, Hasan B.

“…Cell-based therapies using mesenchymal stem cell derived extracellular vesicles (EVs) improve neurologic outcomes in animal models of traumatic brain injury…”
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Improvement of Blood-Brain Barrier Integrity in Traumatic Brain Injury and Hemorrhagic Shock Following Treatment With Valproic Acid and Fresh Frozen Plasma by Nikolian, Vahagn C., Dekker, Simone E., Bambakidis, Ted, Higgins, Gerald A., Dennahy, Isabel S., Georgoff, Patrick E., Williams, Aaron M., Andjelkovic, Anuska V., Alam, Hasan B.

“…OBJECTIVE:Combined traumatic brain injury and hemorrhagic shock are highly lethal. Following injuries, the integrity of the blood-brain barrier can be…”
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Different resuscitation strategies and novel pharmacologic treatment with valproic acid in traumatic brain injury by Dekker, Simone E., Nikolian, Vahagn C., Sillesen, Martin, Bambakidis, Ted, Schober, Patrick, Alam, Hasan B.

“…Traumatic brain injury (TBI) is a leading cause of death in young adults, and effective treatment strategies have the potential to save many lives. TBI results…”
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Modulation of Brain Transcriptome by Combined Histone Deacetylase Inhibition and Plasma Treatment Following Traumatic Brain Injury and Hemorrhagic Shock by Dekker, Simone E., Biesterveld, Ben E., Bambakidis, Ted, Williams, Aaron M., Tagett, Rebecca, Johnson, Craig N., Sillesen, Martin, Liu, Baoling, Li, Yongqing, Alam, Hasan B.

“…We previously showed that the addition of valproic acid (VPA), a histone deacetylase inhibitor, to fresh frozen plasma (FFP) resuscitation attenuates brain…”
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Resuscitation with Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock by Bambakidis, Ted, Dekker, Simone E, Sillesen, Martin, Liu, Baoling, Johnson, Craig N, Jin, Guang, de Vries, Helga E, Li, Yongqing, Alam, Hasan B

“…Traumatic brain injury and hemorrhagic shock (TBI+HS) elicit a complex inflammatory response that contributes to secondary brain injury. There is currently no…”
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