Search Results - "Dejnirattisai, Wanwisa"
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Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera
Published in Cell (29-04-2021)“…The race to produce vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began when the first sequence was published, and this forms…”
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Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum
Published in Cell (05-08-2021)“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone progressive change, with variants conferring advantage rapidly becoming dominant…”
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Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera
Published in Cell (15-04-2021)“…SARS-CoV-2 has caused over 2 million deaths in little over a year. Vaccines are being deployed at scale, aiming to generate responses against the virus spike…”
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Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines
Published in Nature medicine (01-05-2022)“…Antibody responses are an important part of immunity after Coronavirus Disease 2019 (COVID-19) vaccination. However, antibody trajectories and the associated…”
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A protective Zika virus E-dimer-based subunit vaccine engineered to abrogate antibody-dependent enhancement of dengue infection
Published in Nature immunology (01-10-2019)“…Infections with dengue virus (DENV) and Zika virus (ZIKV) can induce cross-reactive antibody responses. Two immunodominant epitopes—one to precursor membrane…”
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Structural basis of potent Zika–dengue virus antibody cross-neutralization
Published in Nature (London) (04-08-2016)“…Zika virus is a member of the Flavivirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to…”
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The antigenic anatomy of SARS-CoV-2 receptor binding domain
Published in Cell (15-04-2021)“…Antibodies are crucial to immune protection against SARS-CoV-2, with some in emergency use as therapeutics. Here, we identify 377 human monoclonal antibodies…”
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Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins
Published in Nature communications (23-02-2021)“…Flaviviruses such as Dengue (DENV) or Zika virus (ZIKV) assemble into an immature form within the endoplasmatic reticulum (ER), and are then processed by furin…”
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Cross-Reacting Antibodies Enhance Dengue Virus Infection in Humans
Published in Science (American Association for the Advancement of Science) (07-05-2010)“…Dengue virus co-circulates as four serotypes, and sequential infections with more than one serotype are common. One hypothesis for the increased severity seen…”
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Longitudinal Analysis of Antibody Cross-neutralization Following Zika Virus and Dengue Virus Infection in Asia and the Americas
Published in The Journal of infectious diseases (13-07-2018)“…The 4 dengue virus serotypes (DENV1-4) and Zika virus (ZIKV) are related mosquito-borne flaviviruses of major importance globally. While monoclonal antibodies…”
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Recognition determinants of broadly neutralizing human antibodies against dengue viruses
Published in Nature (London) (02-04-2015)“…Human antibodies in complex with the soluble dimeric form of the dengue virus envelope protein E recognize a quaternary epitope and exhibit strong neutralizing…”
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Immunodominant T-cell responses to dengue virus NS3 are associated with DHF
Published in Proceedings of the National Academy of Sciences - PNAS (28-09-2010)“…Dengue infections are increasing at an alarming rate in many tropical and subtropical countries, where epidemics can put health care systems under extreme…”
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CryoEM structures of the multimeric secreted NS1, a major factor for dengue hemorrhagic fever
Published in Nature communications (09-11-2022)“…Dengue virus infection can cause dengue hemorrhagic fever (DHF). Dengue NS1 is multifunctional. The intracellular dimeric NS1 (iNS1) forms part of the viral…”
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Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope
Published in Nature communications (23-05-2017)“…A problem in the search for an efficient vaccine against dengue virus is the immunodominance of the fusion loop epitope (FLE), a segment of the envelope…”
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Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
Published in Nature communications (22-06-2018)“…Zika virus (ZIKV) emerged on a global scale and no licensed vaccine ensures long-lasting anti-ZIKV immunity. Here we report the design and comparative…”
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The alteration of NK cells phenotypes related to the functions and dengue disease outcomes
Published in Virus research (01-07-2024)“…•The NKp30 receptor's expression on activated NK cells is more pronounced in DF patients than in DHF patients, suggesting a potential role of this receptor in…”
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Symptoms and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Positivity in the General Population in the United Kingdom
Published in Clinical infectious diseases (24-08-2022)“…Abstract Background “Classic” symptoms (cough, fever, loss of taste/smell) prompt severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain…”
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The SARS-CoV-2 neutralizing antibody response to SD1 and its evasion by BA.2.86
Published in Nature communications (28-03-2024)“…Under pressure from neutralising antibodies induced by vaccination or infection the SARS-CoV-2 spike gene has become a hotspot for evolutionary change, leading…”
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Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus
Published in Nature immunology (01-11-2018)“…Dengue virus is a major pathogen, and severe infections can lead to life-threatening dengue hemorrhagic fever. Dengue virus exists as four serotypes, and…”
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Native-like SARS-CoV-2 Spike Glycoprotein Expressed by ChAdOx1 nCoV-19/AZD1222 Vaccine
Published in ACS central science (28-04-2021)“…Vaccine development against the SARS-CoV-2 virus focuses on the principal target of the neutralizing immune response, the spike (S) glycoprotein…”
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