Search Results - "Dejgaard, Kurt"

AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3 by Paquette, Mathieu, El-Houjeiri, Leeanna, C. Zirden, Linda, Puustinen, Pietri, Blanchette, Paola, Jeong, Hyeonju, Dejgaard, Kurt, Siegel, Peter M., Pause, Arnim

“…Increased macroautophagy/autophagy and lysosomal activity promote tumor growth, survival and chemo-resistance. During acute starvation, autophagy is rapidly…”
Get full text

Low free drug concentration prevents inhibition of F508del CFTR functional expression by the potentiator VX‐770 (ivacaftor) by Matthes, Elizabeth, Goepp, Julie, Carlile, Graeme W, Luo, Yishan, Dejgaard, Kurt, Billet, Arnaud, Robert, Renaud, Thomas, David Y, Hanrahan, John W

“…Background and Purpose The most common cystic fibrosis (CF) mutation F508del inhibits the gating and surface expression of CFTR, a plasma membrane anion…”
Get full text

An Interaction Map of Endoplasmic Reticulum Chaperones and Foldases by Jansen, Gregor, Määttänen, Pekka, Denisov, Alexey Y., Scarffe, Leslie, Schade, Babette, Balghi, Haouaria, Dejgaard, Kurt, Chen, Leanna Y., Muller, William J., Gehring, Kalle, Thomas, David Y.

“…Chaperones and foldases in the endoplasmic reticulum (ER) ensure correct protein folding. Extensive protein-protein interaction maps have defined the…”
Get full text

Rab18 and Rab43 have key roles in ER-Golgi trafficking by Dejgaard, Selma Y, Murshid, Ayesha, Erman, Ayşegül, Kızılay, Özge, Verbich, David, Lodge, Robert, Dejgaard, Kurt, Ly-Hartig, Thi Bach Nga, Pepperkok, Rainer, Simpson, Jeremy C, Presley, John F

“…Rabs and Arfs/Arls are Ras-related small GTPases of particular relevance to membrane trafficking. It is thought that these proteins regulate specific pathways…”
Get full text

Organization of the Sec61 Translocon, Studied by High Resolution Native Electrophoresis by Dejgaard, Kurt, Theberge, Jean-Francois, Heath-Engel, Hannah, Chevet, Eric, Tremblay, Michel L, Thomas, David Y

“…Cotranslational translocation of polypeptides into the ER is controlled by the dynamic interaction of ribosome and translocon components. Analysis of the steps…”
Get full text

Multiple 40-kDa heat-shock protein chaperones function in Tom70-dependent mitochondrial import by Bhangoo, Melanie K, Tzankov, Stefan, Fan, Anna C Y, Dejgaard, Kurt, Thomas, David Y, Young, Jason C

“…Mitochondrial preproteins that are imported via the translocase of the mitochondrial outer membrane (Tom)70 receptor are complexed with cytosolic chaperones…”
Get full text

Integrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency by Dufour, Catherine R., Xia, Hui, B’chir, Wafa, Perry, Marie-Claude, Kuzmanov, Uros, Gainullina, Anastasiia, Dejgaard, Kurt, Scholtes, Charlotte, Ouellet, Carlo, Zuo, Dongmei, Sanguin-Gendreau, Virginie, Guluzian, Christina, Smith, Harvey W., Muller, William J., Audet-Walsh, Etienne, Sergushichev, Alexey A., Emili, Andrew, Giguère, Vincent

“…Functional oncogenic links between ErbB2 and ERRα in HER2+ breast cancer patients support a therapeutic benefit of co-targeted therapies. However, ErbB2 and…”
Get full text

Alternative Splicing of a Receptor Intracellular Domain Yields Different Ectodomain Conformations, Enabling Isoform-Selective Functional Ligands by Brahimi, Fouad, Galan, Alba, Jmaeff, Sean, Barcelona, Pablo F., De Jay, Nicolas, Dejgaard, Kurt, Young, Jason C., Kleinman, Claudia L., Thomas, David Y., Saragovi, H. Uri

“…Events at a receptor ectodomain affect the intracellular domain conformation, activating signal transduction (out-to-in conformational effects). We…”
Get full text

gp25L/emp24/p24 Protein Family Members of the cis-Golgi Network Bind Both COP I and II Coatomer by Dominguez, Michel, Dejgaard, Kurt, Füllekrug, Joachim, Dahan, Sophie, Fazel, Ali, Paccaud, Jean-Pierre, Thomas, David Y., John J. M. Bergeron, Nilsson, Tommy

“…Five mammalian members of the gp25L/emp24/p24 family have been identified as major constituents of the cis-Golgi network of rat liver and HeLa cells. Two of…”
Get full text

Major Peanut Allergens Ara h 1, Ara h 2 and Ara h 8 Are Degraded and Fragmented Following High-Pressure and Temperature Autoclaving by Cohen, Casey, Dejgaard, Kurt, Jean-Claude, Bertrand, Mazer, Bruce

Get full text

Heterogeneous Nuclear Ribonucleoproteins H, H′, and F Are Members of a Ubiquitously Expressed Subfamily of Related but Distinct Proteins Encoded by Genes Mapping to Different Chromosomes by Bent, Honoré, Hanne, H. Rasmussen, Henrik, Vorum, Kurt, Dejgaard, Xiangdang, Liu, Pavel, Gromov, Peder, Madsen, Borbala, Gesser, Niels, Tommerup, Julio, E. Celis

“…Molecular cDNA cloning, two-dimensional gel immunoblotting, and amino acid microsequencing identified three sequence-unique and distinct proteins that…”
Get full text

Putative Protein Interactome of the Rhomboid Protease RHBDL4 by Hsiao, Jacqueline Melissa, Penalva, Ylauna Christine Mégane, Wu, Helen Yee-Li, Xiao, Bin, Jansen, Gregor, Dejgaard, Kurt, Young, Jason C., Munter, Lisa Marie

“…The physiological functions of the rhomboid-related protein 4 (RHBDL4) are emerging, but their molecular details remain unclear. Because increased expression…”
Get full text

Human 2-D PAGE databases for proteome analysis in health and disease: http ://biobase.dk/cgi-bin/celis by Celis, Julio E., Gromov, Pavel, Østergaard, Morten, Madsen, Peder, Honoré, Bent, Dejgaard, Kurt, Olsen, Eydfinnur, Vorum, Henrik, Kristensen, Dan Bach, Gromova, Irina, Haunsø, Anders, Van Damme, Josef, Puype, Magda, Vandekerckhove, Joel, Holm Rasmussen, Hanne

“…Human 2-D PAGE Databases established at the Danish Centre for Human Genome Research are now available on the World Wide Web (http://biobase.dk/cgi-bin/celis)…”
Get full text

Abstract LB054: A novel chemical proteomics approach toward the identification of kinase targets to sensitize tumour cells to the standard of care drug paclitaxel by Baryyan, Alaa Omar, Timiraos, Ana Belen Fraga, Dejgaard, Kurt, Jean-Claude, Bertrand J.

“…Abstract Introduction: Chemotherapy, through various signaling pathways changes the kinase activation profiles in tumour cells and it has been shown that…”
Get full text

Identification, molecular cloning, expression and chromosome mapping of a family of transformation upregulated hnRNP-K proteins derived by alternative splicing by Dejgaard, K, Leffers, H, Rasmussen, H H, Madsen, P, Kruse, T A, Gesser, B, Nielsen, H, Celis, J E

“…Acidic nuclear proteins (M(r) between 64,000 and 66,000; pI 4.9 to 5.5) that are highly upregulated in transformed cells and that belong to the hnRNP-K family…”
Get more information

Quantitative proteomics reveals differentially expressed proteins in murine preneoplastic intestine in a model of intestinal tumorigenesis induced by low dietary folate and MTHFR deficiency by Leclerc, Daniel, Dejgaard, Kurt, Mazur, Alexander, Deng, Liyuan, Wu, Qing, Nilsson, Tommy, Rozen, Rima

“…Colorectal cancer risk is increased when dietary folate intake is low, with or without a deficiency in methylenetetrahydrofolate reductase (MTHFR). We have…”
Get full text

Circulating extracellular vesicles containing S100A9 reflect histopathology, immunophenotype and therapeutic responses of liver metastasis in colorectal cancer patients by Tsamchoe, Migmar, Lazaris, Anthoula, Kim, Diane, Krzywon, Lucyna, Bloom, Jessica, Mayer, Thomas, Petrillo, Stephanie K, Dejgaard, Kurt, Gao, Zu-Hua, Rak, Janusz, Metrakos, Peter

“…Metastasis is the principal cause of cancer treatment failure and an area of dire diagnostic needs. Colorectal cancer metastases to the liver (CRCLMs) are…”
Get full text

Akt and AMPK activators rescue hyperexcitability in neurons from patients with bipolar disorderResearch in context by Anouar Khayachi, Malak Abuzgaya, Yumin Liu, Chuan Jiao, Kurt Dejgaard, Lenka Schorova, Anusha Kamesh, Qin He, Yuting Cousineau, Alessia Pietrantonio, Nargess Farhangdoost, Charles-Etienne Castonguay, Boris Chaumette, Martin Alda, Guy A. Rouleau, Austen J. Milnerwood

“…Background: Bipolar disorder (BD) is a multifactorial psychiatric illness affecting ∼1% of the global adult population. Lithium (Li), is the most effective…”
Get full text

Akt and AMPK activators rescue hyperexcitability in neurons from patients with bipolar disorder by Khayachi, Anouar, Abuzgaya, Malak, Liu, Yumin, Jiao, Chuan, Dejgaard, Kurt, Schorova, Lenka, Kamesh, Anusha, He, Qin, Cousineau, Yuting, Pietrantonio, Alessia, Farhangdoost, Nargess, Castonguay, Charles-Etienne, Chaumette, Boris, Alda, Martin, Rouleau, Guy A., Milnerwood, Austen J.

“…Bipolar disorder (BD) is a multifactorial psychiatric illness affecting ∼1% of the global adult population. Lithium (Li), is the most effective mood stabilizer…”
Get full text

Adaptation of Leishmania donovani to Cutaneous and Visceral Environments: in Vivo Selection and Proteomic Analysis by McCall, Laura-Isobel, Zhang, Wen-Wei, Dejgaard, Kurt, Atayde, Vanessa Diniz, Mazur, Alexander, Ranasinghe, Shalindra, Liu, Jing, Olivier, Martin, Nilsson, Tommy, Matlashewski, Greg

“…Leishmaniasis is a neglected tropical disease caused by Leishmania protozoa. Two main forms are found in the Old World, self-limited cutaneous leishmaniasis…”
Get full text