Search Results - "Dejean, Anne"
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Repositioning TH cell polarization from single cytokines to complex help
Published in Nature immunology (01-10-2021)“…When helper T (T H ) cell polarization was initially described three decades ago, the T H cell universe grew dramatically. New subsets were described based on…”
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The role of Eomes in human CD4 T cell differentiation: A question of context
Published in European journal of immunology (01-01-2019)“…Eomesodermin (Eomes) is a transcription factor (TF) of the T‐box family closely related to T‐bet known for its role in CD8 T cell and natural killer cell…”
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3
Repositioning T H cell polarization from single cytokines to complex help
Published in Nature immunology (01-10-2021)“…When helper T (T ) cell polarization was initially described three decades ago, the T cell universe grew dramatically. New subsets were described based on…”
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4
Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy
Published in Immunity (Cambridge, Mass.) (13-10-2020)“…CD8+ T cells within the tumor microenvironment (TME) are exposed to various signals that ultimately determine functional outcomes. Here, we examined the role…”
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5
Positive regulation of Vav1 by Themis controls CD4 T cell pathogenicity in a mouse model of central nervous system inflammation
Published in Cellular and molecular life sciences : CMLS (01-12-2024)“…The susceptibility to autoimmune diseases is conditioned by the association of modest genetic alterations which altogether weaken self-tolerance. The mechanism…”
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6
Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit
Published in Nature communications (19-11-2014)“…Cellular senescence is a stable cell cycle arrest that limits the proliferation of pre-cancerous cells. Here we demonstrate that scaffold-attachment-factor A…”
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Acanthocytosis in an alectinib‐treated patient
Published in British journal of haematology (01-04-2022)Get full text
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8
miR-221 overexpression contributes to liver tumorigenesis
Published in Proceedings of the National Academy of Sciences - PNAS (05-01-2010)“…MicroRNA (miRNAs) are negative regulators of gene expression and can function as tumor suppressors or oncogenes. Expression patterns of miRNAs and their role…”
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9
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
Published in Nature immunology (01-02-2009)“…Factors governing T cell homeostasis are poorly defined. Hedrick and colleagues find that the transcription factor Foxo1 maintains the homeostasis of naive T…”
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Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes
Published in Immunity (Cambridge, Mass.) (18-10-2016)“…The transcription factor Foxo3 plays a crucial role in myeloid cell function but its role in lymphoid cells remains poorly defined. Here, we have shown that…”
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11
SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States
Published in Cell stem cell (01-11-2018)“…Understanding general principles that safeguard cellular identity should reveal critical insights into common mechanisms underlying specification of varied…”
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Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes
Published in Nature immunology (01-07-2024)“…Immune cells experience large cell shape changes during environmental patrolling because of the physical constraints that they encounter while migrating…”
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13
p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
Published in The Journal of experimental medicine (09-05-2011)“…p53 suppresses tumor progression and metastasis. Epithelial-mesenchymal transition (EMT) is a key process in tumor progression and metastasis. The…”
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14
Feasibility of predicting the outcome of fetal infection with cytomegalovirus at the time of prenatal diagnosis
Published in American journal of obstetrics and gynecology (01-09-2016)“…Background Congenital cytomegalovirus infection occurs in 0.7% of live births with 15-20% of infected children developing long-term disability including…”
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15
Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells
Published in Nature communications (14-09-2021)“…EOMES and T-BET are related T-box transcription factors that control natural killer (NK) cell development. Here we demonstrate that EOMES and T-BET regulate…”
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Loss of the E2 SUMO-conjugating enzyme Ube2i in oocytes during ovarian folliculogenesis causes infertility in mice
Published in Development (Cambridge) (02-12-2019)“…The number and quality of oocytes within the ovarian reserve largely determines fertility and reproductive lifespan in mammals. An oocyte-specific…”
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Highly specialized role of Forkhead box O transcription factors in the immune system
Published in Antioxidants & redox signaling (15-02-2011)“…Recent studies have highlighted a fundamental role for Forkhead box O (Foxo) transcription factors in immune system homeostasis. Initial reports designed to…”
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C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress-Induced Ferroptosis in FLT3-Mutant Leukemia
Published in Cancer discovery (07-07-2023)“…Although transcription factor CCAAT-enhancer binding protein α (C/EBPα) is critical for normal and leukemic differentiation, its role in cell and metabolic…”
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Arkadia, a Novel SUMO-Targeted Ubiquitin Ligase Involved in PML Degradation
Published in Molecular and Cellular Biology (01-06-2013)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Eomes-dependent mitochondrial regulation promotes survival of pathogenic CD4+ T cells during inflammation
Published in The Journal of experimental medicine (05-02-2024)“…The mechanisms whereby Eomes controls tissue accumulation of T cells and strengthens inflammation remain ill-defined. Here, we show that Eomes deletion in…”
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