Search Results - "Deitmer, Joachim W"

Proton Transport in Cancer Cells: The Role of Carbonic Anhydrases by Becker, Holger M, Deitmer, Joachim W

“…Intra- and extracellular pH regulation is a pivotal function of all cells and tissues. Net outward transport of H is a prerequisite for normal physiological…”
Get full text

Tight coupling of astrocyte energy metabolism to synaptic activity revealed by genetically encoded FRET nanosensors in hippocampal tissue by Ruminot, Iván, Schmälzle, Jana, Leyton, Belén, Barros, L Felipe, Deitmer, Joachim W

“…The potassium ion, K+, a neuronal signal that is released during excitatory synaptic activity, produces acute activation of glucose consumption in cultured…”
Get full text

Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis by Deitmer, Joachim W, Theparambil, Shefeeq M, Ruminot, Ivan, Noor, Sina I, Becker, Holger M

“…Regulation of metabolism is complex and involves enzymes and membrane transporters, which form networks to support energy dynamics. Lactate, as a metabolic…”
Get full text

Transport Metabolons and Acid/Base Balance in Tumor Cells by Becker, Holger M, Deitmer, Joachim W

“…Solid tumors are metabolically highly active tissues, which produce large amounts of acid. The acid/base balance in tumor cells is regulated by the concerted…”
Get full text

Reversed electrogenic sodium bicarbonate cotransporter 1 is the major acid loader during recovery from cytosolic alkalosis in mouse cortical astrocytes by Theparambil, Shefeeq M., Naoshin, Zinnia, Thyssen, Anne, Deitmer, Joachim W.

“…Key points The regulation of H+i from cytosolic alkalosis has generally been attributed to the activity of Cl–‐coupled acid loaders/base extruders in most cell…”
Get full text

Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function by Jamali, Somayeh, Klier, Michael, Ames, Samantha, Felipe Barros, L., McKenna, Robert, Deitmer, Joachim W., Becker, Holger M.

“…The most aggressive tumour cells, which often reside in hypoxic environments, rely on glycolysis for energy production. Thereby they release vast amounts of…”
Get full text

Mechanisms of CO2/H+ Sensitivity of Astrocytes by Turovsky, Egor, Theparambil, Shefeeq M, Kasymov, Vitaliy, Deitmer, Joachim W, Del Arroyo, Ana Gutierrez, Ackland, Gareth L, Corneveaux, Jason J, Allen, April N, Huentelman, Matthew J, Kasparov, Sergey, Marina, Nephtali, Gourine, Alexander V

“…Ventral regions of the medulla oblongata of the brainstem are populated by astrocytes sensitive to physiological changes in P /[H ]. These astrocytes respond…”
Get full text

The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels by Bavi, Navid, Cortes, D. Marien, Cox, Charles D., Rohde, Paul R., Liu, Weihong, Deitmer, Joachim W., Bavi, Omid, Strop, Pavel, Hill, Adam P., Rees, Douglas, Corry, Ben, Perozo, Eduardo, Martinac, Boris

“…The bacterial mechanosensitive channel MscL gates in response to membrane tension as a result of mechanical force transmitted directly to the channel from the…”
Get full text

Neuronal control of astrocytic respiration through a variant of the Crabtree effect by Fernández-Moncada, Ignacio, Ruminot, Iván, Robles-Maldonado, Daniel, Alegría, Karin, Deitmer, Joachim W., Barros, L. Felipe

“…Aerobic glycolysis is a phenomenon that in the long term contributes to synaptic formation and growth, is reduced by normal aging, and correlates with amyloid…”
Get full text

Cytosolic sodium regulation in mouse cortical astrocytes and its dependence on potassium and bicarbonate by Noor, Zinnia N., Deitmer, Joachim W., Theparambil, Shefeeq M.

“…Sodium plays a major role in different astrocytic functions, including maintenance of ion homeostasis and uptake of neurotransmitters and metabolites, which…”
Get full text

A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells by Noor, Sina Ibne, Jamali, Somayeh, Ames, Samantha, Langer, Silke, Deitmer, Joachim W, Becker, Holger M

“…Many tumor cells produce vast amounts of lactate and acid, which have to be removed from the cell to prevent intracellular lactacidosis and suffocation of…”
Get full text

Bergmann Glial AMPA Receptors Are Required for Fine Motor Coordination by Saab, Aiman S., Neumeyer, Alexander, Jahn, Hannah M., Cupido, Alexander, Šimek, Antonia A. M., Boele, Henk-Jan, Scheller, Anja, Le Meur, Karim, Götz, Magdalena, Monyer, Hannah, Sprengel, Rolf, Rubio, Maria E., Deitmer, Joachim W., De Zeeuw, Chris I., Kirchhoff, Frank

“…The impact of glial neurotransmitter receptors in vivo is still elusive. In the cerebellum, Bergmann glial (BG) cells express…”
Get full text

Functional assessment of SLC4A11, an integral membrane protein mutated in corneal dystrophies by Loganathan, Sampath K, Schneider, Hans-Peter, Morgan, Patricio E, Deitmer, Joachim W, Casey, Joseph R

“…SLC4A11, a member of the SLC4 family of bicarbonate transporters, is a widely expressed integral membrane protein, abundant in kidney and cornea. Mutations of…”
Get more information

Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II by Becker, Holger M, Klier, Michael, Schüler, Christina, McKenna, Robert, Deitmer, Joachim W

“…Carbonic anhydrases (CAs) catalyze the reversible hydration of CO₂ to HCO₃⁻ and H⁺. The rate-limiting step in this reaction is the shuttle of protons between…”
Get full text

The electrogenic sodium bicarbonate cotransporter NBCe1 is a high-affinity bicarbonate carrier in cortical astrocytes by Theparambil, Shefeeq M, Ruminot, Iván, Schneider, Hans-Peter, Shull, Gary E, Deitmer, Joachim W

“…The electrogenic sodium bicarbonate cotransporter NBCe1 (SLC4A4) is a robust regulator of intracellular H(+) and a significant base carrier in many cell types…”
Get full text

Nonenzymatic Proton Handling by Carbonic Anhydrase II during H+-Lactate Cotransport via Monocarboxylate Transporter 1 by Becker, Holger M., Deitmer, Joachim W.

“…Carbonic anhydrase (CA) is a ubiquitous enzyme catalyzing the equilibration of carbon dioxide, protons, and bicarbonate. For several acid/base-coupled membrane…”
Get full text

14-3-3 Proteins and Other Candidates form Protein-Protein Interactions with the Cytosolic C-terminal End of SOS1 Affecting Its Transport Activity by Duscha, Kerstin, Martins Rodrigues, Cristina, Müller, Maria, Wartenberg, Ruth, Fliegel, Larry, Deitmer, Joachim W, Jung, Martin, Zimmermann, Richard, Neuhaus, H Ekkehard

“…The plasma membrane transporter SOS1 (SALT-OVERLY SENSITIVE1) is vital for plant survival under salt stress. SOS1 activity is tightly regulated, but little is…”
Get full text

Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters by Forero-Quintero, Linda S., Deitmer, Joachim W., Becker, Holger M.

“…Epilepsy is a chronic neurological disorder that affects approximately 50 million people worldwide. Ketogenic diet (KD) can be a very effective treatment for…”
Get full text

GABA uptake-dependent Ca²⁺ signaling in developing olfactory bulb astrocytes by Doengi, Michael, Hirnet, Daniela, Coulon, Philippe, Pape, Hans-Christian, Deitmer, Joachim W, Lohr, Christian

“…We studied GABAergic signaling in astrocytes of olfactory bulb slices using confocal Ca²⁺ imaging and two-photon Na⁺ imaging. GABA evoked Ca²⁺ transients in…”
Get full text

Bicarbonate sensing in mouse cortical astrocytes during extracellular acid/base disturbances by Theparambil, Shefeeq M., Naoshin, Zinnia, Defren, Sabrina, Schmaelzle, Jana, Weber, Tobias, Schneider, Hans‐Peter, Deitmer, Joachim W.

“…Key points The present study suggests that the electrogenic sodium–bicarbonate cotransporter, NBCe1, supported by carbonic anhydrase II, CAII, provides an…”
Get full text