Search Results - "Deisseroth, Karl"

The form and function of channelrhodopsin by Deisseroth, Karl, Hegemann, Peter

“…Channelrhodopsins are light-gated ion channels that, via regulation of flagellar function, enable single-celled motile algae to seek ambient light conditions…”
Get full text

Optogenetics and Psychiatry: Applications, Challenges, and Opportunities by Deisseroth, Karl

Get full text

Advanced CLARITY for rapid and high-resolution imaging of intact tissues by Tomer, Raju, Ye, Li, Hsueh, Brian, Deisseroth, Karl

“…CLARITY enables the chemical transformation of intact biological tissues into a hydrogel–tissue hybrid. The hybrid samples can be interrogated using light and…”
Get full text

The development and application of optogenetics by Fenno, Lief, Yizhar, Ofer, Deisseroth, Karl

“…Genetically encoded, single-component optogenetic tools have made a significant impact on neuroscience, enabling specific modulation of selected cells within…”
Get full text

Optogenetic investigation of neural circuits underlying brain disease in animal models by Tye, Kay M., Deisseroth, Karl

“…Key Points 'Optogenetic' approaches (the use of light-sensitive genetically encodable tools to manipulate cellular activity) in neuroscience have matured…”
Get full text

All-Optical Interrogation of Neural Circuits by Emiliani, Valentina, Cohen, Adam E, Deisseroth, Karl, Häusser, Michael

“…There have been two recent revolutionary advances in neuroscience: First, genetically encoded activity sensors have brought the goal of optical detection of…”
Get full text

Wave optics theory and 3-D deconvolution for the light field microscope by Broxton, Michael, Grosenick, Logan, Yang, Samuel, Cohen, Noy, Andalman, Aaron, Deisseroth, Karl, Levoy, Marc

“…Light field microscopy is a new technique for high-speed volumetric imaging of weakly scattering or fluorescent specimens. It employs an array of microlenses…”
Get full text

Communication in Neural Circuits: Tools, Opportunities, and Challenges by Lerner, Talia N., Ye, Li, Deisseroth, Karl

“…Communication, the effective delivery of information, is fundamental to life across all scales and species. Nervous systems (by necessity) may be most…”
Get full text

A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System by de Jong, Johannes W., Afjei, Seyedeh Atiyeh, Pollak Dorocic, Iskra, Peck, James R., Liu, Christine, Kim, Christina K., Tian, Lin, Deisseroth, Karl, Lammel, Stephan

“…Ventral tegmental area (VTA) dopamine (DA) neurons play a central role in mediating motivated behaviors, but the circuitry through which they signal positive…”
Get full text

Synaptic Encoding of Fear Extinction in mPFC-amygdala Circuits by Cho, Jun-Hyeong, Deisseroth, Karl, Bolshakov, Vadim Y.

“…Retrieval of fear extinction memory is associated with increased firing of neurons in the medial prefrontal cortex (mPFC). It is unknown, however, how…”
Get full text

Optogenetic stimulation of a hippocampal engram activates fear memory recall by Liu, Xu, Ramirez, Steve, Pang, Petti T., Puryear, Corey B., Govindarajan, Arvind, Deisseroth, Karl, Tonegawa, Susumu

“…The activation of a population of hippocampal neurons thought to encode a specific fear memory is shown to elicit freezing behaviour in mice. Neural…”
Get full text

Two genetically, anatomically and functionally distinct cell types segregate across anteroposterior axis of paraventricular thalamus by Gao, Claire, Leng, Yan, Ma, Jun, Rooke, Victoria, Rodriguez-Gonzalez, Shakira, Ramakrishnan, Charu, Deisseroth, Karl, Penzo, Mario A.

“…Unlike the sensory thalamus, studies on the functional organization of the midline and intralaminar nuclei are scarce, and this has hindered the establishment…”
Get full text

Three-dimensional intact-tissue sequencing of single-cell transcriptional states by Wang, Xiao, Allen, William E, Wright, Matthew A, Sylwestrak, Emily L, Samusik, Nikolay, Vesuna, Sam, Evans, Kathryn, Liu, Cindy, Ramakrishnan, Charu, Liu, Jia, Nolan, Garry P, Bava, Felice-Alessio, Deisseroth, Karl

“…Retrieving high-content gene-expression information while retaining three-dimensional (3D) positional anatomy at cellular resolution has been difficult,…”
Get full text

Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches by Poulin, Jean-Francois, Caronia, Giuliana, Hofer, Caitlyn, Cui, Qiaoling, Helm, Brandon, Ramakrishnan, Charu, Chan, C. Savio, Dombeck, Daniel A., Deisseroth, Karl, Awatramani, Rajeshwar

“…Midbrain dopamine (DA) neurons have diverse functions that can in part be explained by their heterogeneity. Although molecularly distinct subtypes of DA…”
Get full text

Thirst regulates motivated behavior through modulation of brainwide neural population dynamics by Allen, William E, Chen, Michael Z, Pichamoorthy, Nandini, Tien, Rebecca H, Pachitariu, Marius, Luo, Liqun, Deisseroth, Karl

“…Physiological needs produce motivational drives, such as thirst and hunger, that regulate behaviors essential to survival. Hypothalamic neurons sense these…”
Get full text

Gating of social reward by oxytocin in the ventral tegmental area by Hung, Lin W., Neuner, Sophie, Polepalli, Jai S., Beier, Kevin T., Wright, Matthew, Walsh, Jessica J., Lewis, Eastman M., Luo, Liqun, Deisseroth, Karl, Dölen, Gül, Malenka, Robert C.

“…The reward generated by social interactions is critical for promoting prosocial behaviors. Here we present evidence that oxytocin (OXT) release in the ventral…”
Get full text

Cortical layer-specific critical dynamics triggering perception by Marshel, James H, Kim, Yoon Seok, Machado, Timothy A, Quirin, Sean, Benson, Brandon, Kadmon, Jonathan, Raja, Cephra, Chibukhchyan, Adelaida, Ramakrishnan, Charu, Inoue, Masatoshi, Shane, Janelle C, McKnight, Douglas J, Yoshizawa, Susumu, Kato, Hideaki E, Ganguli, Surya, Deisseroth, Karl

“…Perceptual experiences may arise from neuronal activity patterns in mammalian neocortex. We probed mouse neocortex during visual discrimination using a…”
Get full text

Next-generation probes, particles, and proteins for neural interfacing by Rivnay, Jonathan, Wang, Huiliang, Fenno, Lief, Deisseroth, Karl, Malliaras, George G

“…Bidirectional interfacing with the nervous system enables neuroscience research, diagnosis, and therapy. This two-way communication allows us to monitor the…”
Get full text

Thalamic control of sensory selection in divided attention by Wimmer, Ralf D., Schmitt, L. Ian, Davidson, Thomas J., Nakajima, Miho, Deisseroth, Karl, Halassa, Michael M.

“…The authors trained mice to attend to or suppress vision based on behavioral context and show, through novel and established techniques, that changes in visual…”
Get full text

Projections from neocortex mediate top-down control of memory retrieval by Rajasethupathy, Priyamvada, Sankaran, Sethuraman, Marshel, James H., Kim, Christina K., Ferenczi, Emily, Lee, Soo Yeun, Berndt, Andre, Ramakrishnan, Charu, Jaffe, Anna, Lo, Maisie, Liston, Conor, Deisseroth, Karl

“…Top-down prefrontal cortex inputs to the hippocampus have been hypothesized to be important in memory consolidation, retrieval, and the pathophysiology of…”
Get full text