Radiotherapy in marginal zone lymphoma

Radiotherapy in marginal zone lymphoma

To evaluate the efficacy of radiotherapy (RT) for early-stage nodal and extranodal marginal zone lymphoma (MZL). Patients with stage I (n = 22) and stage II (n = 8) MZL, who were treated with RT were reviewed. The primary tumor localisation was in the orbita (n = 12), stomach (n = 8), head and neck...

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Bibliographic Details
Published in:Radiation oncology (London, England) Vol. 8; no. 1; p. 2
Main Authors: Deinbeck, Kristin, Geinitz, Hans, Haller, Bernhard, Fakhrian, Khashayar
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 02-01-2013
BioMed Central
BMC
Subjects:
Adult
Aged
Aged, 80 and over
Care and treatment
Disease-Free Survival
Female
Gastric lymphoma
Humans
Lymphoma
Lymphoma, B-Cell, Marginal Zone - radiotherapy
Male
MALT
Marginal zone lymphoma
Medical research
Medical statistics
Medicine, Experimental
Middle Aged
Non-Hodgkin's lymphomas
Patients
Prognosis
Radiation therapy
Radiotherapy
Radiotherapy Dosage
Recurrence
Salvage Therapy - methods
Statistical methods
Time Factors
Treatment Outcome
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Summary:To evaluate the efficacy of radiotherapy (RT) for early-stage nodal and extranodal marginal zone lymphoma (MZL). Patients with stage I (n = 22) and stage II (n = 8) MZL, who were treated with RT were reviewed. The primary tumor localisation was in the orbita (n = 12), stomach (n = 8), head and neck other than the orbita (n = 8), breast (n = 1) and one case of marginal zone lymphoma of the skin (n = 1). The median radiotherapy dose was 40 Gy (5 to 45 Gy). The median follow-up time was 103 months. The 5-year overall survival and event-free survival rates were 85 ± 7% and 71 ± 9%, respectively. There was no infield recurrence. Recurrence occurred outside of the radiation field in six patients. The relapses were treated with salvage RT and had excellent local control (100%) at five years after salvage RT. Localized extranodal MZL have an excellent prognosis following moderate-dose RT. RT is also an effective salvage therapy in cases of localized recurrence. Further clinical studies should evaluate the optimal dose for MZL.
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ISSN:1748-717X
1748-717X
DOI:10.1186/1748-717x-8-2