Search Results - "Deichmann, K. A."

Genetic variants of IL-13 signalling and human asthma and atopy by HEINZMANN, A, MAO, X.-Q, ROBERTS, M. H, SUGIMOTO, R, ARIMA, K, ARINOBU, Y, YU, B, KRUSE, S, ENOMOTO, T, DAKE, Y, KAWAI, M, SHIMAZU, S, AKAIWA, M, SASAKI, S, ADRA, C. N, KITAICHI, M, INOUE, H, YAMAUCHI, K, TOMICHI, N, KURIMOTO, F, HAMASAKI, N, HOPKIN, J. M, IZUHARA, K, KREOMER, R. T, SHIRAKAWA, T, DEICHMANN, K. A, GAO, P.-S, OHSHIMA, K, UMESHITA, R, ABE, Y, BRAUN, S, YAMASHITA, T

“…Asthma and atopy show epidemiological association and are biologically linked by T-helper type 2 (T(h)2) cytokine-driven inflammatory mechanisms. IL-4 operates…”
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Association study of polymorphisms within interleukin‐18 in juvenile idiopathic arthritis and bronchial asthma by Heinzmann, A., Gerhold, K., Ganter, K., Kurz, T., Schuchmann, L., Keitzer, R., Berner, R., Deichmann, K. A.

“…Background:  Interleukin‐18 (IL‐18) plays an important role in the regulation of TH1 as well as TH2 immunologic responses and thus in the development of…”
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Linkage and allelic association of atopy and markers flanking the IL4-receptor gene by Deichmann, K. A., Heinzmann, A., Forster, J., Dischinger, S., Mehl, C., Brueggenolte, E., Hildebrandt, F., Moseler, M., Kuehr, J.

“…Background Atopy, a clinical syndrome characterized by heightened IgE responsiveness, is largely determined by genetic factors. The disease may well be…”
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A genome‐wide screen on the genetics of atopy in a multiethnic European population reveals a major atopy locus on chromosome 3q21.3 by Kurz, T., Altmueller, J., Strauch, K., Rüschendorf, F., Heinzmann, A., Moffatt, M. F., Cookson, W. O. C. M., Inacio, F., Nürnberg, P., Stassen, H. H., Deichmann, K. A.

“…Background:  Dissecting complex diseases in underlying distinct traits and studying these for their genetic basis might enhance the power as well as the…”
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The polymorphisms S503P and Q576R in the interleukin‐4 receptor α gene are associated with atopy and influence the signal transduction by Kruse, S, Japha, T, Tedner, M, Sparholt, S H, Forster, J, Kuehr, J, Deichmann, K A

“…Interleukin‐4 (IL‐4) plays a major role in immunoglobulin E (IgE) production. Its signal is conferred to effector cells through binding to the α chain of the…”
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The Ile198Thr and Ala379Val Variants of Plasmatic Paf-Acetylhydrolase Impair Catalytical Activities and Are Associated with Atopy and Asthma by Kruse, Susanne, Mao, Xiao-Quan, Heinzmann, Andrea, Blattmann, Sabine, Roberts, Mark H., Braun, Sandra, Gao, Pei-Song, Forster, Johannes, Kuehr, Joachim, Hopkin, Julian M., Shirakawa, Taro, Deichmann, Klaus A.

“…The platelet-activating factor (PAF) represents a phospholipid with complex biological functions, including involvement in inflammatory processes. The…”
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Confirmation of association of IL‐15 with pediatric asthma and comparison of different controls by Bierbaum, S., Nickel, R., Zitnik, S., Ahlert, I., Lau, S., Deichmann, K. A., Wahn, U., Heinzmann, A.

“…Background:  Interleukin (IL)‐15 is an important mediator in chronic inflammatory diseases. Recently, we have described the association of IL‐15 haplotypes…”
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A comprehensive candidate gene study on bronchial asthma and juvenile idiopathic arthritis by Schubert, K, von Bonnsdorf, H, Burke, M, Ahlert, I, Braun, S, Berner, R, Deichmann, K A, Heinzmann, A

“…Bronchial asthma and juvenile idiopathic arthritis (JIA) are complex genetic diseases. As both represent chronic inflammatory diseases it is likely that they…”
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A First Trial of Retrospective Collaboration for Positional Cloning in Complex Inheritance: Assay of the Cytokine Region on Chromosome 5 by the Consortium on Asthma Genetics (COAG) by Lonjou, C., Barnes, K., Chen, H., W. O. C. M. Cookson, Deichmann, K. A., Hall, I. P., Holloway, J. W., Laitinen, T., Palmer, L. J., Wjst, M., Morton, N. E.

“…The central problem of complex inheritance is to map oligogenes for disease susceptibility, integrating linkage and association over samples that differ in…”
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Association study of polymorphisms within matrix metalloproteinase 9 with bronchial asthma by Ganter, K., Deichmann, K. A., Heinzmann, A.

“…Summary Matrix metalloproteinase 9 plays an important role in the development of bronchial asthma. We were interested in whether the polymorphisms –T1702A,…”
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A novel polymorphism in the 5' promoter region of the human interleukin-4 receptor alpha-chain gene is associated with decreased soluble interleukin-4 receptor protein levels by Hackstein, H, Hecker, M, Kruse, S, Bohnert, A, Ober, C, Deichmann, K A, Bein, G

“…Interleukin (IL)-4 exerts its biological effects through binding to the IL-4 receptor (IL4R) complex, plays a central role in stimulating B-cell…”
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Genetic linkage of HLA-class II locus to mite-specific IgE immune responsiveness by STEPHAN, V, KUEHR, J, SEIBT, A, SAUERESSIG, H, ZINGSEM, S, DINH, T. D, MOSELER, M, WAHN, V, DEICHMANN, K. A

“…Background IgE response to common inhalant allergens seems to be the major determinant of the development of atopic rhinitis and asthma but it has been…”
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Identification of common polymorphisms in the mitochondrial genome by Heinzmann, A., Thoma, C., Dietrich, H., Deichmann, K. A.

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Studies on linkage and association of atopy with the chromosomal region 12q13-24 by Heinzmann, A., Grotherr, P., Jerkic, S.-P., Lichtenberg, A., Braun, S., Kruse, S., Forster, J., Kuehr, J., Deichmann, K. A.

“…Background Several studies have shown linkage of bronchial asthma, allergic rhinitis and total serum IgE concentration to the chromosomal region 12q13–24 in…”
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The recognition pattern of sequential B cell epitopes of beta-lactoglobulin does not vary with the clinical manifestations of cow's milk allergy by Heinzmann, A, Blattmann, S, Spuergin, P, Forster, J, Deichmann, K A

“…beta-Lactoglobulin (BLG) represents one of the major allergens causing cow's milk allergy (CMA) - a disease with a wide spectrum of clinical symptoms. The aim…”
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Linkage and association studies of atopy and the chromosome 11q13 region by Deichmann, Klaus A, Starke, Barbara, Schlenther, Simone, Heinzmann, Andrea, Sparholt, Susanne Hauschildt, Forster, Johannes, Kuehr, Joachim

“…The clinical syndrome atopy is largely determined by genetic factors. In 1989, the first linkage of markers within and flanking the chromosomal region 11q13…”
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A retrospective collaboration on chromosome 5 by the International Consortium on Asthma Genetics (COAG) by Palmer, L.J., Lonjou, C., Barnes, K., Chen, H., Cookson, W.O.C.M., Deichmann, K.A., Holloway, J.W., Laitinen, T., Wjst, M., Morton, N.E.

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Parametric and Nonparametric Multipoint Linkage Analysis with Imprinting and Two-Locus–Trait Models: Application to Mite Sensitization by Strauch, Konstantin, Fimmers, Rolf, Kurz, Thorsten, Deichmann, Klaus A., Wienker, Thomas F., Baur, Max P.

“…We present two extensions to linkage analysis for genetically complex traits. The first extension allows investigators to perform parametric (LOD-score)…”
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Genes for atopy and asthma by Heinzmann, Andrea, Deichmann, Klaus A

“…The genetic basis of atopic diseases is represented by a complex network of interacting genes or common genetic variants rather than a few disease-causing…”
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Single Region Linkage Analyses of Asthma: Description of Data Sets by Palmer, Lyle J., Cookson, William O.C.M., Deichmann, Klaus A., Holloway, John W., Laitinen, Tarja

“…Linkage (genotypic) data from the 5q31–33 candidate region for asthma were contributed to Genetic Analysis Workshop 12 by members of the International…”
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