Search Results - "Deiana, Serena"

The cholinergic system and spatial learning by Deiana, Serena, Platt, Bettina, Riedel, Gernot

“…► Spatial memory represents a simple form of episodic-like memory in rodents. ► During spatial acquisition ACh efflux is immediate in hippocampus and cortex. ►…”
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Sustained MK-801 induced deficit in a novel probabilistic reversal learning task by Latuske, Patrick, von Heimendahl, Moritz, Deiana, Serena, Wotjak, Carsten T., du Hoffmann, Johann

“…Cognitive flexibility, the ability to adapt to unexpected changes, is critical for healthy environmental and social interactions, and thus to everyday…”
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Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models by Melis, Valeria, Magbagbeolu, Mandy, Rickard, Janet E, Horsley, David, Davidson, Kathleen, Harrington, Kathleen A, Goatman, Keith, Goatman, Elizabeth A, Deiana, Serena, Close, Steve P, Zabke, Claudia, Stamer, Karsten, Dietze, Silke, Schwab, Karima, Storey, John M.D, Harrington, Charles R, Wischik, Claude M, Theuring, Franz, Riedel, Gernot

“…Given the repeated failure of amyloid-based approaches in Alzheimer’s disease, there is increasing interest in tau-based therapeutics. Although…”
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Medical use of cannabis. Cannabidiol: A new light for schizophrenia? by Deiana, Serena

“…The medical properties of cannabis have been known for many centuries; its first documented use dates back to 2800 BC when it was described for its…”
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An endocannabinoid mechanism in relapse to drug seeking: A review of animal studies and clinical perspectives by Fattore, Liana, Spano, M. Sabrina, Deiana, Serena, Melis, Valeria, Cossu, Gregorio, Fadda, Paola, Fratta, Walter

“…Abstract Detoxification from drug abuse is strongly threatened by the occurrence of renewed episodes of drug intake. In human addicts, relapse to drug seeking…”
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Pro-cognitive effects of the GlyT1 inhibitor Bitopertin in rodents by Deiana, Serena, Hauber, Wolfgang, Munster, Alexandra, Sommer, Susanne, Ferger, Boris, Marti, Anelise, Schmid, Bernhard, Dorner-Ciossek, Cornelia, Rosenbrock, Holger

“…N-methyl-D-aspartate-receptor (NMDAR) hypofunction contributes to cognitive impairments in neuropsychiatric disorders such as schizophrenia. Reduced NMDAR…”
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Targeting the dopamine D1 receptor or its downstream signalling by inhibiting phosphodiesterase‐1 improves cognitive performance by Pekcec, Anton, Schülert, Niklas, Stierstorfer, Birgit, Deiana, Serena, Dorner‐Ciossek, Cornelia, Rosenbrock, Holger

“…Background and Purpose Insufficient prefrontal dopamine 1 (D1) receptor signalling has been linked to cognitive dysfunction in several psychiatric conditions…”
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Long-term adaptation of prefrontal circuits in a mouse model of NMDAR hypofunction by Ponserre, Marion, Ionescu, Tudor M., Franz, Alessa A., Deiana, Serena, Schuelert, Niklas, Lamla, Thorsten, Williams, Rhîannan H., Wotjak, Carsten T., Hobson, Scott, Dine, Julien, Omrani, Azar

“…Pharmacological approaches to induce N-methyl-d-aspartate receptor (NMDAR) hypofunction have been intensively used to understand the aetiology and…”
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Effects of GPR139 agonism on effort expenditure for food reward in rodent models: Evidence for pro-motivational actions by Münster, Alexandra, Sommer, Susanne, Kúkeľová, Diana, Sigrist, Hannes, Koros, Eliza, Deiana, Serena, Klinder, Klaus, Baader-Pagler, Tamara, Mayer-Wrangowski, Svenja, Ferger, Boris, Bretschneider, Tom, Pryce, Christopher R., Hauber, Wolfgang, von Heimendahl, Moritz

“…Apathy, deficiency of motivation including willingness to exert effort for reward, is a common symptom in many psychiatric and neurological disorders,…”
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MK-801-induced deficits in social recognition in rats: reversal by aripiprazole, but not olanzapine, risperidone, or cannabidiol by Deiana, Serena, Watanabe, Akihito, Yamasaki, Yuki, Amada, Naoki, Kikuchi, Tetsuro, Stott, Colin, Riedel, Gernot

“…Deficiencies in social activities are hallmarks of numerous brain disorders. With respect to schizophrenia, social withdrawal belongs to the category of…”
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Optogenetic activation of mesencephalic projections to the nucleus accumbens shell impairs probabilistic reversal learning by disrupting learning from negative reinforcement by Zühlsdorff, Katharina, Sala-Bayo, Júlia, Piller, Sammy, Zhukovsky, Peter, Lamla, Thorsten, Nissen, Wiebke, von Heimendahl, Moritz, Deiana, Serena, Nicholson, Janet R, Robbins, Trevor W, Alsiö, Johan, Dalley, Jeffrey W

“…Cognitive flexibility, the capacity to adapt behaviour to changes in the environment, is impaired in a range of brain disorders, including schizophrenia and…”
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Targeting the dopamine D 1 receptor or its downstream signalling by inhibiting phosphodiesterase-1 improves cognitive performance by Pekcec, Anton, Schülert, Niklas, Stierstorfer, Birgit, Deiana, Serena, Dorner-Ciossek, Cornelia, Rosenbrock, Holger

“…Insufficient prefrontal dopamine 1 (D ) receptor signalling has been linked to cognitive dysfunction in several psychiatric conditions. Because the PDE1…”
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Reactivity to conditioned threat cues is distinct from exploratory drive in the elevated plus maze by Hilton, Joe R., Simpson, Susannah R., Sherman, Emily R., Raby‐Smith, Will, Azvine, Keemia, Arribas, Maite, Zhou, Jiaqi, Deiana, Serena, Hengerer, Bastian, Cahill, Emma N.

“…Fear and anxiety are adaptive states that allow humans and animals alike to respond appropriately to threatening cues in their environment. Commonly used tasks…”
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Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine by Deiana, Serena, Harrington, Charles R., Wischik, Claude M., Riedel, Gernot

“…Rationale The cholinergic system is involved in cognition as well as in age-related cognitive decline and Alzheimer disease (AD). Cholinergic enhancers…”
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PM537. GPR52 agonists show pro-cognitive properties by von Heimendahl, Moritz, Arban, Roberto, Deiana, Serena, Hobson, Scott, Rosenbrock, Holger, Schülert, Niklas

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The cholinergic system and spatial learning: The cholinergic system and brain function by DEIANA, Serena, PLATT, Bettina, RIEDEL, Gernot

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Strain and schedule-dependent differences in the acquisition, maintenance and extinction of intravenous cannabinoid self-administration in rats by Deiana, Serena, Fattore, Liana, Sabrina Spano, M., Cossu, Gregorio, Porcu, Emanuele, Fadda, Paola, Fratta, Walter

“…Cannabinoids have been reported to sustain self-administration in laboratory animals; however, genetic differences and environmental factors critical in the…”
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Cannabinoid CB1 antagonist SR 141716A attenuates reinstatement of heroin self-administration in heroin-abstinent rats by Fattore, Liana, Spano, Sabrina, Cossu, Gregorio, Deiana, Serena, Fadda, Paola, Fratta, Walter

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Endocannabinoid system and opioid addiction: Behavioural aspects by Fattore, Liana, Deiana, Serena, Spano, Sabrina M., Cossu, Gregorio, Fadda, Paola, Scherma, Maria, Fratta, Walter

“…Cannabinoids produce a variety of pharmacological effects very similar to those elicited by opioids. Direct and indirect interactions with opioid system have…”
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CB1 receptor agonist and heroin, but not cocaine, reinstate cannabinoid‐seeking behaviour in the rat by Spano, M Sabrina, Fattore, Liana, Cossu, Gregorio, Deiana, Serena, Fadda, Paola, Fratta, Walter

“…We recently provided evidence for a functional link between cannabinoid and opioid endogenous systems in relapse to heroin‐seeking behaviour in rats. In the…”
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