Search Results - "Dehn, Shirley"

Myeloid receptor CD36 is required for early phagocytosis of myocardial infarcts and induction of Nr4a1‐dependent mechanisms of cardiac repair by Dehn, Shirley, Thorp, Edward B.

“…Phagocytosis after myocardial infarction (MI) is a prerequisite to cardiac repair. Recruited monocytes clear necrotic cardiomyocytes and differentiate into…”
Get full text

MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair After Myocardial Ischemia Reperfusion Injury by DeBerge, Matthew, Yeap, Xin Yi, Dehn, Shirley, Zhang, Shuang, Grigoryeva, Lubov, Misener, Sol, Procissi, Daniel, Zhou, Xin, Lee, Daniel C, Muller, William A, Luo, Xunrong, Rothlin, Carla, Tabas, Ira, Thorp, Edward B

“…RATIONALE:Clinical benefits of reperfusion after myocardial infarction are offset by maladaptive innate immune cell function, and therapeutic interventions are…”
Get full text

Enhanced Efferocytosis of Apoptotic Cardiomyocytes Through Myeloid-Epithelial-Reproductive Tyrosine Kinase Links Acute Inflammation Resolution to Cardiac Repair After Infarction by Wan, Elaine, Yeap, Xin Yi, Dehn, Shirley, Terry, Rachael, Novak, Margaret, Zhang, Shuang, Iwata, Shinichi, Han, Xiaoqiang, Homma, Shunichi, Drosatos, Konstantinos, Lomasney, Jon, Engman, David M., Miller, Stephen D., Vaughan, Douglas E., Morrow, John P., Kishore, Raj, Thorp, Edward B.

“…RATIONALE:Efficient clearance of apoptotic cells (efferocytosis) is a prerequisite for inflammation resolution and tissue repair. After myocardial infarction,…”
Get full text

Probing the stability and mechanism for folding of the GrpE1-112 tetrameric deletion mutant of the GrpE protein from E. coli by Mehl, Andrew F., Okada, Kelby, Dehn, Shirley M., Kurian, Sarah

“…► The stability and folding of a tetrameric deletion mutant of GrpE was studied by CD and CD stopped-flow. ► The GrpE1-112 mutant has low stability with a…”
Get full text

ACAT Inhibition Reduces the Progression of Preexisting, Advanced Atherosclerotic Mouse Lesions Without Plaque or Systemic Toxicity by Rong, James X, Blachford, Courtney, Feig, Jonathan E, Bander, Ilda, Mayne, Jeffrey, Kusunoki, Jun, Miller, Christine, Davis, Matthew, Wilson, Martha, Dehn, Shirley, Thorp, Edward, Tabas, Ira, Taubman, Mark B, Rudel, Lawrence L, Fisher, Edward A

“…OBJECTIVE—Acyl-CoA:cholesterol acyltransferase (ACAT) converts cholesterol to cholesteryl esters in plaque foam cells. Complete deficiency of macrophage ACAT…”
Get full text

Hypoxia inducible factor-2α in resting macrophages tempers mitochondrial reactive oxygen species to selectively repress MARCO-dependent phagocytosis by Dehn, Shirley, Thorp, Edward B

“…Abstract Hypoxia Inducible Factor α (HIF-α) isoforms promote many key components during wound healing including angiogenesis and glycolytic energy metabolism…”
Get full text

Hypoxia-inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair by DeBerge, Matthew, Lantz, Connor, Dehn, Shirley, Sullivan, David P, van der Laan, Anja M, Niessen, Hans W M, Flanagan, Margaret E, Brat, Daniel J, Feinstein, Matthew J, Kaushal, Sunjay, Wilsbacher, Lisa D, Thorp, Edward B

“…Hypoxia-inducible factors (HIFs) are activated in parenchymal cells in response to low oxygen and as such have been proposed as therapeutic targets during…”
Get full text

Monocytes prime autoreactive T cells after myocardial infarction by DeBerge, Matthew, Yu, Shuangjin, Dehn, Shirley, Ifergan, Igal, Yeap, Xin Yi, Filipp, Mallory, Becker, Amanda, Luo, Xunrong, Miller, Stephen, Thorp, Edward B

“…In humans, loss of central tolerance for the cardiac self-antigen α-myosin heavy chain (α-MHC) leads to circulation of cardiac autoreactive T cells and renders…”
Get more information

HIF-2α in Resting Macrophages Tempers Mitochondrial Reactive Oxygen Species To Selectively Repress MARCO-Dependent Phagocytosis by Dehn, Shirley, DeBerge, Matthew, Yeap, Xin-Yi, Yvan-Charvet, Laurent, Fang, Deyu, Eltzschig, Holger K, Miller, Stephen D, Thorp, Edward B

“…Hypoxia-inducible factor (HIF)-α isoforms regulate key macrophage (MΦ) functions during ischemic inflammation. HIF-2α drives proinflammatory cytokine…”
Get full text

Mechanisms of Macrophage-Directed Inflammation Resolution by Dehn, Shirley

“…Efferocytosis is the anti-inflammatory removal of dying cells and cellular debris, occurring billions of times per person, per day as a part of homeostatic…”
Get full text

HIF-2α in Resting Macrophages Tempers Mitochondrial ROS to Selectively Repress MARCO-dependent Phagocytosis by Dehn, Shirley, DeBerge, Matthew, Yeap, Xin-Yi, Yvan-Charvet, Laurent, Fang, Deyu, Eltzschig, Holger K., Miller, Stephen D., Thorp, Edward B.

“…H ypoxia I nducible F actor α (HIF-α) isoforms regulate key macrophage (Mϕ) functions during ischemic inflammation. HIF-2α drives pro-inflammatory cytokine…”
Get full text

Cardiomyocytes induce macrophage receptor shedding to suppress phagocytosis by Zhang, Shuang, Yeap, Xin-Yi, Grigoryeva, Lubov, Dehn, Shirley, DeBerge, Matthew, Tye, Michael, Rostlund, Emily, Schrijvers, Dorien, Zhang, Zheng Jenny, Sumagin, Ronen, Tourtellotte, Warren G, Lee, Daniel, Lomasney, Jon, Morrow, John, Thorp, Edward B

“…Abstract Background Mobilization of the innate immune response to clear and metabolize necrotic and apoptotic cardiomyocytes is a prerequisite to heart repair…”
Get full text

Quantitation of acute necrosis after experimental myocardial infarction by Yeap, Xin-Yi, Dehn, Shirley, Adelman, Jeremy, Lipsitz, Jeremy, Thorp, Edward B

“…Myocardial infarction (MI) is death and necrosis of myocardial tissue secondary to ischemia. MI is associated with adverse cardiac remodeling, progressive…”
Get more information

Phagocyte–myocyte interactions and consequences during hypoxic wound healing by Zhang, Shuang, Dehn, Shirley, DeBerge, Matthew, Rhee, Ki-Jong, Hudson, Barry, Thorp, Edward B.

“…•The molecular mediators of phagocyte–myocyte interactions are just beginning to be studied.•We review critical phagocytes populations in the heart during…”
Get full text

Enhanced Efferocytosis of Apoptotic Cardiomyocytes Through MER Tyrosine Kinase Links Acute Inflammation Resolution to Cardiac Repair After Infarction by Wan, Elaine, Yeap, Xin Yi, Dehn, Shirley, Terry, Rachael, Novak, Margaret, Zhang, Shuang, Iwata, Shinichi, Han, Xiaoqiang, Homma, Shunichi, Drosatos, Konstantinos, Lomasney, Jon, Engman, David M., Miller, Stephen D., Vaughan, Douglas E., Morrow, John P., Kishore, Raj, Thorp, Edward B.

Get full text

ACAT inhibition reduces the progression of pre-existing, advanced atherosclerotic mouse lesions without plaque or systemic toxicity by Rong, James X., Blachford, Courtney, Feig, Jonathan E., Bander, Ilda, Mayne, Jeffrey, Kusunoki, Jun, Miller, Christine, Davis, Matthew, Wilson, Martha, Dehn, Shirley, Thorp, Edward, Tabas, Ira, Taubman, Mark B., Rudel, Lawrence L., Fisher, Edward A.

Get full text