Plasma YKL-40, as a prognostic tumor marker in recurrent ovarian cancer

Plasma YKL-40, as a prognostic tumor marker in recurrent ovarian cancer

YKL-40, a member of family 18 glycosyl hydrolases, is secreted by cancer cells. The function of YKL-40 in cancer diseases is unknown, but it is a growth factor of connective tissue cells and probably has a role in inflammation and remodeling of the extracellular matrix, a process also involved in me...

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Bibliographic Details
Published in:Acta obstetricia et gynecologica Scandinavica Vol. 82; no. 3; p. 287
Main Authors: Dehn, Hannah, Høgdall, Estrid V S, Johansen, Julia S, Jørgensen, Morten, Price, Paul A, Engelholm, Svend A A, Høgdall, Claus K
Format: Journal Article
Language:English
Published: United States 01-03-2003
Subjects:
Adipokines
Adult
Aged
Biomarkers, Tumor - blood
CA-125 Antigen - blood
Chitinase-3-Like Protein 1
Female
Glycoproteins - blood
Humans
Lectins
Middle Aged
Neoplasm Recurrence, Local - blood
Ovarian Neoplasms - blood
Predictive Value of Tests
Proportional Hazards Models
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Summary:YKL-40, a member of family 18 glycosyl hydrolases, is secreted by cancer cells. The function of YKL-40 in cancer diseases is unknown, but it is a growth factor of connective tissue cells and probably has a role in inflammation and remodeling of the extracellular matrix, a process also involved in metastatic malignant diseases. High serum YKL-40 has been associated with poor prognosis for patients with colorectal and recurrent breast cancer. The purpose of the present study was to examine the prognostic value of plasma YKL-40 in patients presenting with recurring ovarian cancer. YKL-40 was determined by ELISA in plasma samples from 73 patients with relapse of ovarian cancer shortly before start of second-line chemotherapy. The endpoint used was death because of ovarian cancer. Plasma YKL-40 was increased in ovarian cancer patients (median 94 micro g/L, range 20-1970 micro g/L) compared with age-matched controls (33 micro g/L, range 20-130 micro g/L) (p < 0.001). Fifty-five per cent of the patients had a plasma YKL-40 level above the upper normal 95th percentile of controls. Patients with high plasma YKL-40 (i.e. > 130 micro g/L or > 160 micro g/L) at the time of relapse had significantly shorter survival than patients with normal levels (respectively p = 0.007 and p = 0.004). Plasma YKL-40 proved to be an independent prognostic factor in a multivariate Cox analysis (YKL-40 > 160 micro g/L; HR = 2.27) (p = 0.006), including serum CA-125 and clinical/histological parameters. High plasma YKL-40 is related to short survival in patients with recurrent ovarian cancer.
ISSN:0001-6349
DOI:10.1034/j.1600-0412.2003.00010.x