Search Results - "Dehghani, Tima"
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Endothelial cells, neutrophils and platelets: getting to the bottom of an inflammatory triangle
Published in Open biology (01-10-2020)“…Severe fibrotic and thrombotic events permeate the healthcare system, causing suffering for millions of patients with inflammatory disorders. As late-state…”
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Journal Article -
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Comparison of Endothelial Differentiation Capacities of Human and Rat Adipose-Derived Stem Cells
Published in Plastic and reconstructive surgery (1963) (01-12-2016)“…The authors compared the endothelial differentiation capacities of human and rat adipose-derived stem cells to determine whether human adipose-derived stem…”
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1592-P: Evaluating TRIB1 as a Genetic Driver of Fatty Liver Disease in an In Vitro Model of Carbohydrate-Mediated Lipid Accumulation
Published in Diabetes (New York, N.Y.) (01-06-2024)“…Metabolic dysfunction associated steatotic liver disease (MASLD) is the most common liver disease and is characterized by increased lipid accumulation in the…”
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Selectin-targeting glycosaminoglycan-peptide conjugate limits neutrophil-mediated cardiac reperfusion injury
Published in Cardiovascular research (07-01-2022)“…Abstract Aims One of the hallmarks of myocardial infarction (MI) is excessive inflammation. During an inflammatory insult, damaged endothelial cells shed their…”
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Biological Band-Aids: Design and Application of a Glycosaminoglycan-Peptide Conjugate to Regulate Cell-Cell Interactions During Acute Inflammation
Published 01-01-2021“…After an acute inflammatory event such as a heart attack, stroke, or organ transplant, blood vessels and circulating immune cells take on a complex phenotype…”
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Dissertation -
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Mitigating neutrophil trafficking and cardiotoxicity with DS-IkL in a microphysiological system of a cytokine storm
Published in Lab on a chip (28-06-2023)“…A feature of severe COVID-19 is the onset of an acute and intense systemic inflammatory response referred to as the "cytokine storm". The cytokine storm is…”
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Journal Article -
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Proangiogenic Collagen-Binding Glycan Therapeutic Promotes Endothelial Cell Angiogenesis
Published in ACS biomaterials science & engineering (12-07-2021)“…Stimulating angiogenesis during wound healing continues to present a significant clinical challenge, given the limitations of current strategies to maintain…”
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Journal Article -
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Selectin-Targeting Peptide–Glycosaminoglycan Conjugates Modulate Neutrophil–Endothelial Interactions
Published in Cellular and molecular bioengineering (01-02-2019)“…Introduction The glycocalyx is a layer of glycoproteins, proteoglycans and glycosaminoglycans that coats the luminal surface of most blood vessels. It…”
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