Search Results - "Dehay, B."

Alpha-synuclein-based models of Parkinson's disease by Dehay, B., Fernagut, P.-O.

“…Parkinson's disease is a progressive neurodegenerative disorder mainly characterized by the loss of dopaminergic neurons from the substantia nigra pars…”
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Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency by Ramonet, D, Perier, C, Recasens, A, Dehay, B, Bové, J, Costa, V, Scorrano, L, Vila, M

“…Mitochondrial complex I dysfunction has long been associated with Parkinson’s disease (PD). Recent evidence suggests that mitochondrial involvement in PD may…”
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Efficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and induced pluripotent stem cells by Sánchez-Danés, A, Consiglio, A, Richaud, Y, Rodríguez-Pizà, I, Dehay, B, Edel, M, Bové, J, Memo, M, Vila, M, Raya, A, Izpisua Belmonte, J C

“…Human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) offer great hope for in vitro modeling of Parkinson's disease (PD), as well as for…”
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In utero delivery of rAAV2/9 induces neuronal expression of the transgene in the brain: towards new models of Parkinson’s disease by Chansel-Debordeaux, L, Bourdenx, M, Dovero, S, Grouthier, V, Dutheil, N, Espana, A, Groc, L, Jimenez, C, Bezard, E, Dehay, B

“…Animal models are essential tools for basic pathophysiological research as well as validation of therapeutic strategies for curing human diseases. However,…”
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Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates by Bourdenx, M, Nioche, A, Dovero, S, Arotcarena, M-L, Camus, S, Porras, G, Thiolat, M-L, Rougier, N P, Prigent, A, Aubert, P, Bohic, S, Sandt, C, Laferrière, F, Doudnikoff, E, Kruse, N, Mollenhauer, B, Novello, S, Morari, M, Leste-Lasserre, T, Damas, I Trigo, Goillandeau, M, Perier, C, Estrada, C, Garcia-Carrillo, N, Recasens, A, Vaikath, N N, El-Agnaf, O M A, Herrero, M T, Derkinderen, P, Vila, M, Obeso, J A, Dehay, B, Bezard, E

“…Dopaminergic neuronal cell death, associated with intracellular α-synuclein (α-syn)-rich protein aggregates [termed "Lewy bodies" (LBs)], is a well-established…”
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Targeting Expression of Expanded Polyglutamine Proteins to the Endoplasmic Reticulum or Mitochondria Prevents Their Aggregation by Rousseau, Erwann, Dehay, Benjamin, Ben-Haïem, Léa, Trottier, Yvon, Morange, Michel, Bertolotti, Anne, Jacob, François

“…Aggregation of misfolded proteins is a characteristic of several neurodegenerative diseases. The huntingtin amino-terminal fragment with extended polyglutamine…”
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Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration by Dehay, Benjamin, Ramirez, Alfredo, Martinez-Vicente, Marta, Perier, Celine, Canron, Marie-Hélène, Doudnikoff, Evelyne, Vital, Anne, Vila, Miquel, Klein, Christine, Bezard, Erwan

“…Parkinson disease (PD) is a progressive neurodegenerative disorder pathologically characterized by the loss of dopaminergic neurons from the substantia nigra…”
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Involvement of Autophagy in Levodopa‐Induced Dyskinesia by Feyder, Michael, Plewnia, Carina, Lieberman, Ori J., Spigolon, Giada, Piccin, Alessandro, Urbina, Lidia, Dehay, Benjamin, Li, Qin, Nilsson, Per, Altun, Mikael, Santini, Emanuela, Sulzer, David, Bezard, Erwan, Borgkvist, Anders, Fisone, Gilberto

“…Background Autophagy is intensively studied in cancer, metabolic and neurodegenerative diseases, but little is known about its role in pathological conditions…”
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Synaptic Regulator α-Synuclein in Dopaminergic Fibers Is Essentially Required for the Maintenance of Subependymal Neural Stem Cells by Perez-Villalba, Ana, Sirerol-Piquer, M Salomé, Belenguer, Germán, Soriano-Cantón, Raúl, Muñoz-Manchado, Ana Belén, Villadiego, Javier, Alarcón-Arís, Diana, Soria, Federico N, Dehay, Benjamin, Bezard, Erwan, Vila, Miquel, Bortolozzi, Analía, Toledo-Aral, Juan José, Pérez-Sánchez, Francisco, Fariñas, Isabel

“…Synaptic protein α-synuclein (α-SYN) modulates neurotransmission in a complex and poorly understood manner and aggregates in the cytoplasm of degenerating…”
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Identification of distinct pathological signatures induced by patient-derived -synuclein structures in nonhuman primates by Bourdenx, M., Nioche, A., Dovero, S., Arotcarena, M.-L., Camus, S., Porras, G., Thiolat, M.-L., Rougier, N. P, Prigent, A., Aubert, P., Bohic, S., Sandt, C., Laferrière, Florent, Doudnikoff, E., Kruse, N., Mollenhauer, B., Novello, S., Morari, M., Leste-Lasserre, T., Trigo-Damas, I., Goillandeau, M., Perier, C., Estrada, C., Garcia-Carrillo, N., Recasens, A., Vaikath, N., El-Agnaf, O., Herrero, M., Derkinderen, P., Vila, M., Obeso, J., Dehay, B., Bezard, E.

“…Dopaminergic neuronal cell death, associated with intracellular -synuclein (-syn)-rich protein aggregates [termed "Lewy bodies" (LBs)], is a well-established…”
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Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in non-human primates by Bourdenx, M., Nioche, A., Dovero, S., Arotcarena, M.-L., Camus, S., Porras, G., Thiolat, M.-L., Rougier, N P, Prigent, A., Aubert, P., Bohic, S., Sandt, C., Laferrière, F., Doudnikoff, E., Kruse, N., Mollenhauer, B., Novello, S., Morari, M., Leste-Lasserre, T., Trigo Damas, I., Goillandeau, M., Perier, C., Estrada, C., Garcia-Carrillo, N., Recasens, A., Vaikath, N N, El-Agnaf, O M A, Herrero, M. Trinidad, Derkinderen, P., Vila, M., Obeso, J A, Dehay, B., Bezard, E.

“…A bstract Dopaminergic neuronal cell death, associated with intracellular α-synuclein (α-syn)-rich protein aggregates (termed ‘Lewy bodies’), is a…”
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