Search Results - "Degrelle, Séverine"
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IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise
Published in Science (American Association for the Advancement of Science) (12-07-2019)“…Elevated levels of type I interferon (IFN) during pregnancy are associated with intrauterine growth retardation, preterm birth, and fetal demise through…”
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Novel fluorescent and secreted transcriptional reporters for quantifying activity of the xenobiotic sensor aryl hydrocarbon receptor (AHR)
Published in Environment international (01-11-2022)“…[Display omitted] •We present novel reporters for in vitro study of AhR activity, with high-throughput applications (96/384-well plates).•The systems are based…”
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3
Expression, Localization, and Activity of the Aryl Hydrocarbon Receptor in the Human Placenta
Published in International journal of molecular sciences (01-12-2018)“…The human placenta is an organ between the blood of the mother and the fetus, which is essential for fetal development. It also plays a role as a selective…”
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Placental Overexpression of Soluble CORIN in Preeclampsia
Published in The American journal of pathology (01-05-2020)“…Preeclampsia (PE) is a hypertensive disease of pregnancy associated with substantial maternal and fetal morbidity and mortality. CORIN is a transmembrane type…”
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Mining of combined human placental gene expression data across pregnancy, applied to PPAR signaling pathway
Published in Placenta (Eastbourne) (15-09-2020)“…To date, we have only an incomplete understanding of how gene expression in the human placenta changes at the genome-wide scale from very early in gestation to…”
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Primary Bovine Extra-Embryonic Cultured Cells: A New Resource for the Study of In Vivo Peri-Implanting Phenotypes and Mesoderm Formation
Published in PloS one (12-06-2015)“…In addition to nourishing the embryo, extra-embryonic tissues (EETs) contribute to early embryonic patterning, primitive hematopoiesis, and fetal health. These…”
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Peroxisome proliferator‐activated receptor gamma‐ligand‐binding domain mutations associated with familial partial lipodystrophy type 3 disrupt human trophoblast fusion and fibroblast migration
Published in Journal of cellular and molecular medicine (01-07-2020)“…The transcription factor peroxisome proliferator‐activated receptor gamma (PPARG) is essential for placental development, and alterations in its expression…”
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IFITM1 inhibits trophoblast invasion and is induced in placentas associated with IFN-mediated pregnancy diseases
Published in iScience (21-07-2023)“…Interferon-induced transmembrane proteins (IFITMs) are restriction factors that block many viruses from entering cells. High levels of type I interferon (IFN)…”
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Age and Sex-Related Changes in Human First-Trimester Placenta Transcriptome and Insights into Adaptative Responses to Increased Oxygen
Published in International journal of molecular sciences (12-03-2021)“…Physiological oxygen tension rises dramatically in the placenta between 8 and 14 weeks of gestation. Abnormalities in this period can lead to gestational…”
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10
Expression of pluripotency master regulators during two key developmental transitions: EGA and early lineage specification in the bovine embryo
Published in PloS one (29-03-2012)“…Pluripotency genes are implicated in mouse embryonic genome activation (EGA) and pluripotent lineage specification. Moreover, their expression levels have been…”
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DietSee: An on-hand, portable, strip-type biosensor for lipolysis monitoring via real-time amperometric determination of glycerol in blood
Published in Analytica chimica acta (22-04-2021)“…Glycerol is a clinical biomarker of lipolysis that is mainly produced by adipose tissues. Blood glycerol content increases in pathological conditions such as…”
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Comparative Study of PPARγ Targets in Human Extravillous and Villous Cytotrophoblasts
Published in PPAR research (2020)“…Trophoblasts, as the cells that make up the main part of the placenta, undergo cell differentiation processes such as invasion, migration, and fusion…”
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Understanding bovine embryo elongation: a transcriptomic study of trophoblastic vesicles
Published in Frontiers in physiology (2024)“…During the process of elongation, the embryo increases in size within the uterus, while the extra-embryonic tissues (EETs) develop and differentiate in…”
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14
Fetal-sex determination of human placental tissues
Published in Placenta (Eastbourne) (01-01-2018)“…It is now demonstrated that the sex-specific maternal-placental-fetal interaction plays an important role in placental functions and pathologies. Determination…”
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15
New Transcriptional Reporters to Quantify and Monitor PPARγ Activity
Published in PPAR Research (01-01-2017)“…The peroxisome-proliferator-activated-receptor-γ (PPARγ) is a member of the nuclear receptor superfamily that plays a critical role in diverse biological…”
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16
Single-cell profiling reveals immune disturbances landscape and HLA-F-mediated immune tolerance at the maternal-fetal interface in preeclampsia
Published in Frontiers in immunology (03-10-2023)“…Preeclampsia is a pregnancy-specific disorder that always causes maternal and fetal serious adverse outcome. Disturbances in maternal immune tolerance to…”
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17
Chemotherapy in pregnancy: exploratory study of the effects of paclitaxel on the expression of placental drug transporters
Published in Investigational new drugs (01-10-2019)“…Summary Introduction The use of paclitaxel in pregnant cancer patients is feasible in terms of fetal safety, but little is known about the effects of…”
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18
Conceptus elongation in cattle: Genes, models and questions
Published in Animal reproduction science (01-09-2012)“…In ruminants, more than 30% of the embryonic loss observed after artificial insemination has an early origin that is coincident with the marked elongation of…”
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Uncoupled embryonic and extra-embryonic tissues compromise blastocyst development after somatic cell nuclear transfer
Published in PloS one (06-06-2012)“…Somatic cell nuclear transfer (SCNT) is the most efficient cell reprogramming technique available, especially when working with bovine species. Although SCNT…”
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Dynamic Pattern of HOXB9 Protein Localization during Oocyte Maturation and Early Embryonic Development in Mammals
Published in PloS one (31-10-2016)“…We previously showed that the homeodomain transcription factor HOXB9 is expressed in mammalian oocytes and early embryos. However, a systematic and exhaustive…”
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