Search Results - "Degrave, Wim M"

Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease by de Oliveira, Fabiane L, Araújo-Jorge, Tania C, de Souza, Elen M, de Oliveira, Gabriel M, Degrave, Wim M, Feige, Jean-Jacques, Bailly, Sabine, Waghabi, Mariana C

“…Chagas disease induced by Trypanosoma cruzi (T. cruzi) infection is a major cause of mortality and morbidity affecting the cardiovascular system for which…”
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In Chagas disease, transforming growth factor beta neutralization reduces Trypanosoma cruzi infection and improves cardiac performance by Ferreira, Roberto Rodrigues, de Souza, Elen Mello, Vilar-Pereira, Glaucia, Degrave, Wim M S, Abreu, Rayane da Silva, Meuser-Batista, Marcelo, Ferreira, Nilma Valéria Caldeira, Ledbeter, Steve, Barker, Robert H, Bailly, Sabine, Feige, Jean-Jacques, Lannes-Vieira, Joseli, de Araújo-Jorge, Tania C, Waghabi, Mariana Caldas

“…Chronic Chagasic cardiomyopathy (CCC), a progressive inflammatory and fibrosing disease, is the most prominent clinical form of Chagas disease, a neglected…”
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Genome Sequence of Mycobacterium bovis BCG Moreau, the Brazilian Vaccine Strain against Tuberculosis by Gomes, Leonardo H. F, Otto, Thomas D, Vasconcellos, Érico A, Ferrão, Patrícia M, Maia, Renata M, Moreira, Aline S, Ferreira, Marcelo A, Castello-Branco, Luiz R. R, Degrave, Wim M, Mendonça-Lima, Leila

“…Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the only vaccine available against tuberculosis, and the strains used worldwide represent a family of…”
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Structural modelling and comparative analysis of homologous, analogous and specific proteins from Trypanosoma cruzi versus Homo sapiens: putative drug targets for chagas' disease treatment by Capriles, Priscila V S Z, Guimarães, Ana C R, Otto, Thomas D, Miranda, Antonio B, Dardenne, Laurent E, Degrave, Wim M

“…Trypanosoma cruzi is the etiological agent of Chagas' disease, an endemic infection that causes thousands of deaths every year in Latin America. Therapeutic…”
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The Next Generation Scientist program: capacity-building for future scientific leaders in low- and middle-income countries by Pillai, Goonaseelan, Chibale, Kelly, Constable, Edwin C, Keller, Akiko N, Gutierrez, Marcelo M, Mirza, Fareed, Sengstag, Christian, Masimirembwa, Collen, Denti, Paolo, Maartens, Gary, Ramsay, Michèle, Ogutu, Bernhards, Makonnen, Eyasu, Gordon, Richard, Ferreira, Carlos Gil, Goldbaum, Fernando Alberto, Degrave, Wim M S, Spector, Jonathan, Tadmor, Brigitta, Kaiser, Hedwig J

“…Scientific and professional development opportunities for early career scientists in low- and middle- income countries (LMICs) are limited and not consistent…”
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A phosphoproteomic approach towards the understanding of the role of TGF-β in Trypanosoma cruzi biology by Ferrão, Patrícia M, de Oliveira, Fabiane L, Degrave, Wim M, Araujo-Jorge, Tania C, Mendonça-Lima, Leila, Waghabi, Mariana C

“…Transforming growth factor beta (TGF-β) plays a pivotal role in Chagas disease, not only in the development of chagasic cardiomyopathy, but also in many stages…”
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Proteomic profile of culture filtrate from the Brazilian vaccine strain Mycobacterium bovis BCG Moreau compared to M. bovis BCG Pasteur by Berrêdo-Pinho, Marcia, Kalume, Dario E, Correa, Paloma R, Gomes, Leonardo H F, Pereira, Melissa P, da Silva, Renata F, Castello-Branco, Luiz R R, Degrave, Wim M, Mendonça-Lima, Leila

“…Bacille Calmette-Guerin (BCG) is currently the only available vaccine against tuberculosis (TB) and comprises a heterogeneous family of sub-strains with…”
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AnEnPi: identification and annotation of analogous enzymes by Otto, Thomas D, Guimarães, Ana Carolina R, Degrave, Wim M, de Miranda, Antonio B

“…Enzymes are responsible for the catalysis of the biochemical reactions in metabolic pathways. Analogous enzymes are able to catalyze the same reactions, but…”
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Chemo-Resistant Protein Expression Pattern of Glioblastoma Cells (A172) to Perillyl Alcohol by de Saldanha da Gama Fischer, Juliana, Costa Carvalho, Paulo, da Fonseca, Clovis Orlando, Liao, Lujian, Degrave, Wim M, da Gloria da Costa Carvalho, Maria, Yates, John R, Domont, Gilberto B

“…Glioblastoma multiform (GBM) is by far the most malignant glioma. We have introduced a new treatment for GBMs that comprises the inhalation of a naturally…”
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Trypanosoma cruzi proline racemases are involved in parasite differentiation and infectivity by Chamond, Nathalie, Goytia, Maira, Coatnoan, Nicolas, Barale, Jean‐Christophe, Cosson, Alain, Degrave, Wim M., Minoprio, Paola

“…Summary Polyclonal lymphocyte activation is one of the major immunological disturbances observed after microbial infections and among the primary strategies…”
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A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information by Alves-Ferreira, Marcelo, Guimarães, Ana Carolina Ramos, Capriles, Priscila Vanessa da Silva Zabala, Dardenne, Laurent E, Degrave, Wim M

“…The current drug options for the treatment of chronic Chagas disease have not been sufficient and high hopes have been placed on the use of genomic data from…”
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Inhibition of Trypanosoma cruzi proline racemase affects host-parasite interactions and the outcome of in vitro infection by Coutinho, Leticia, Ferreira, Marcelo Alves, Cosson, Alain, Batista, Marcos Meuser, Batista, Denise da Gama Jaén, Minoprio, Paola, Degrave, Wim M, Berneman, Armand, Soeiro, Maria de Nazaré Correia

“…Proline racemase is an important enzyme of Trypanosoma cruzi and has been shown to be an effective mitogen for B cells, thus contributing to the parasite's…”
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Biochemical Characterization of Proline Racemases from the Human Protozoan Parasite Trypanosoma cruzi and Definition of Putative Protein Signatures by Chamond, Nathalie, Grégoire, Christophe, Coatnoan, Nicolas, Rougeot, Catherine, Freitas-Junior, Lucio Holanda, da Silveira, José Franco, Degrave, Wim M., Minoprio, Paola

“…Proline racemase catalyzes the interconversion of l- andd-proline enantiomers and has to date been described in only two species. Originally found in the…”
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ReRep: computational detection of repetitive sequences in genome survey sequences (GSS) by Otto, Thomas D, Gomes, Leonardo H F, Alves-Ferreira, Marcelo, de Miranda, Antonio B, Degrave, Wim M

“…Genome survey sequences (GSS) offer a preliminary global view of a genome since, unlike ESTs, they cover coding as well as non-coding DNA and include…”
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GO Explorer: A gene-ontology tool to aid in the interpretation of shotgun proteomics data by Carvalho, Paulo C, Fischer, Juliana Sg, Chen, Emily I, Domont, Gilberto B, Carvalho, Maria Gc, Degrave, Wim M, Yates, 3rd, John R, Barbosa, Valmir C

“…Spectral counting is a shotgun proteomics approach comprising the identification and relative quantitation of thousands of proteins in complex mixtures…”
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Squid - a simple bioinformatics grid by Carvalho, Paulo C, Glória, Rafael V, de Miranda, Antonio B, Degrave, Wim M

“…BLAST is a widely used genetic research tool for analysis of similarity between nucleotide and protein sequences. This paper presents a software application…”
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The Trypanosoma cruzi Genome Project: nuclear karyotype and gene mapping of clone CL Brener by Santos, M R, Cano, M I, Schijman, A, Lorenzi, H, Vázquez, M, Levin, M J, Ramirez, J L, Brandão, A, Degrave, W M, da Silveira, J F

“…By using improved pulsed field gel electrophoresis conditions, the molecular karyotype of the reference clone CL Brener selected for Trypanosoma cruzi genome…”
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The changing face of the epidemiology of tuberculosis due to molecular strain typing - A Review by Suffys, P N, de Araujo, M E, Degrave, W M

“…About one third of the world population is infected with tubercle bacilli, causing eight million new cases of tuberculosis (TB) and three million deaths each…”
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An Oligonucleotide Probe Derived from kDNA Minirepeats is Specific for Leishmania (Viannia) by Fernandes, O, Bozza, M, Pascale, J M, de Miranda, A B, Lopes, U G, Degrave, W M

“…Sequence analysis of Leishmania (Viannia) kDNA minicircles and analysis of multiple sequence alignments of the conserved region (minirepeats) of five distinct…”
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Parasite genome initiatives by DEGRAVE, Wim M, MELVILLE, Sara, IVENS, Al, ASLETT, Martin

“…During 1993-1994, scientists from developing and developed countries planned and initiated a number of parasite genome projects and several consortiums for the…”
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