Search Results - "Degraff, Laura M"

Retinoic acid-related orphan receptor γ (RORγ): a novel participant in the diurnal regulation of hepatic gluconeogenesis and insulin sensitivity by Takeda, Yukimasa, Kang, Hong Soon, Freudenberg, Johannes, DeGraff, Laura M, Jothi, Raja, Jetten, Anton M

“…The hepatic circadian clock plays a key role in the daily regulation of glucose metabolism, but the precise molecular mechanisms that coordinate these two…”
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CD44 plays a critical role in regulating diet-induced adipose inflammation, hepatic steatosis, and insulin resistance by Kang, Hong Soon, Liao, Grace, DeGraff, Laura M, Gerrish, Kevin, Bortner, Carl D, Garantziotis, Stavros, Jetten, Anton M

“…CD44 is a multifunctional membrane receptor implicated in the regulation of several biological processes, including inflammation. CD44 expression is elevated…”
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The cytochrome P450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease by Schuck, Robert N, Zha, Weibin, Edin, Matthew L, Gruzdev, Artiom, Vendrov, Kimberly C, Miller, Tricia M, Xu, Zhenghong, Lih, Fred B, DeGraff, Laura M, Tomer, Kenneth B, Jones, H Michael, Makowski, Liza, Huang, Leaf, Poloyac, Samuel M, Zeldin, Darryl C, Lee, Craig R

“…Fatty liver disease is an emerging public health problem without effective therapies, and chronic hepatic inflammation is a key pathologic mediator in its…”
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CYP eicosanoid pathway mediates colon cancer‐promoting effects of dietary linoleic acid by Zhang, Jianan, Yang, Jun, Duval, Caroline, Edin, Matthew L., Williams, Andrea, Lei, Lei, Tu, Maolin, Pourmand, Elham, Song, Renhua, Graves, Joan P., DeGraff, Laura M., Wong, Justin J.‐L., Wang, Yige, Sun, Quancai, Sanidad, Katherine Z., Wong, Siu, Han, Yanhui, Zhang, Zhenyu, Lee, Kin Sing Stephen, Park, Yeonhwa, Xiao, Hang, Liu, Zhenhua, Decker, Eric A., Cui, Wei, Zeldin, Darryl C., Zhang, Guodong

“…Human and animal studies support that consuming a high level of linoleic acid (LA, 18:2ω‐6), an essential fatty acid and key component of the human diet,…”
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CYP2J2 overexpression protects against arrhythmia susceptibility in cardiac hypertrophy by Westphal, Christina, Spallek, Bastian, Konkel, Anne, Marko, Lajos, Qadri, Fatimunnisa, DeGraff, Laura M, Schubert, Carola, Bradbury, J Alyce, Regitz-Zagrosek, Vera, Falck, John R, Zeldin, Darryl C, Müller, Dominik N, Schunck, Wolf-Hagen, Fischer, Robert

“…Maladaptive cardiac hypertrophy predisposes one to arrhythmia and sudden death. Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) promote…”
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Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity by Zha, Weibin, Edin, Matthew L., Vendrov, Kimberly C., Schuck, Robert N., Lih, Fred B., Jat, Jawahar Lal, Bradbury, J. Alyce, DeGraff, Laura M., Hua, Kunjie, Tomer, Kenneth B., Falck, John R., Zeldin, Darryl C., Lee, Craig R.

“…Adipogenesis plays a critical role in the initiation and progression of obesity. Although cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) have…”
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Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice by Lee, Craig R, Imig, John D, Edin, Matthew L, Foley, Julie, DeGraff, Laura M, Bradbury, J. Alyce, Graves, Joan P, Lih, Fred B, Clark, James, Myers, Page, Perrow, A. Ligon, Lepp, Adrienne N, Kannon, M. Alison, Ronnekleiv, Oline K, Alkayed, Nabil J, Falck, John R, Tomer, Kenneth B, Zeldin, Darryl C

“…Renal cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) regulate sodium transport and blood pressure. Although endothelial CYP-derived EETs are…”
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Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice by Deng, Yangmei, Edin, Matthew L., Theken, Katherine N., Schuck, Robert N., Flake, Gordon P., Kannon, M. Alison, DeGraff, Laura M., Lih, Fred B., Foley, Julie, Bradbury, J. Alyce, Graves, Joan P., Tomer, Kenneth B., Falck, John R., Zeldin, Darryl C., Lee, Craig R.

“…ABSTRACT Cytochrome P‐450 (CYP)‐derived epoxyei‐cosatrienoic acids (EETs) possess potent anti‐inflammatory effects in vitro. However, the effect of increased…”
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Gender Differences in Murine Airway Responsiveness and Lipopolysaccharide-Induced Inflammation by Card, Jeffrey W, Carey, Michelle A, Bradbury, J. Alyce, DeGraff, Laura M, Morgan, Daniel L, Moorman, Michael P, Flake, Gordon P, Zeldin, Darryl C

“…The roles of gender and sex hormones in lung function and disease are complex and not completely understood. The present study examined the influence of gender…”
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Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice by Hoopes, Samantha L, Gruzdev, Artiom, Edin, Matthew L, Graves, Joan P, Bradbury, J Alyce, Flake, Gordon P, Lih, Fred B, DeGraff, Laura M, Zeldin, Darryl C

“…Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play an important role in blood pressure…”
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Overexpression of CYP2J2 provides protection against doxorubicin-induced cardiotoxicity by Zhang, Yunfang, El-Sikhry, Haitham, Chaudhary, Ketul R, Batchu, Sri Nagarjun, Shayeganpour, Anooshirvan, Jukar, Taibeh Orujy, Bradbury, J Alyce, Graves, Joan P, DeGraff, Laura M, Myers, Page, Rouse, Douglas C, Foley, Julie, Nyska, Abraham, Zeldin, Darryl C, Seubert, John M

“…Human cytochrome P-450 (CYP)2J2 is abundant in heart and active in biosynthesis of epoxyeicosatrienoic acids (EETs). Recently, we demonstrated that these…”
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Role of Soluble Epoxide Hydrolase in Postischemic Recovery of Heart Contractile Function by Seubert, John M, Sinal, Christopher J, Graves, Joan, DeGraff, Laura M, Bradbury, J Alyce, Lee, Craig R, Goralski, Kerry, Carey, Michelle A, Luria, Ayala, Newman, John W, Hammock, Bruce D, Falck, John R, Roberts, Holly, Rockman, Howard A, Murphy, Elizabeth, Zeldin, Darryl C

“…Cytochrome P450 epoxygenases metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) which are converted to dihydroxyeicosatrienoic acids (DHETs) by…”
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Enhanced Postischemic Functional Recovery in CYP2J2 Transgenic Hearts Involves Mitochondrial ATP-Sensitive K+ Channels and p42/p44 MAPK Pathway by Seubert, John, Yang, Baichun, Bradbury, J Alyce, Graves, Joan, Degraff, Laura M, Gabel, Scott, Gooch, Rebecca, Foley, Julie, Newman, John, Mao, Lan, Rockman, Howard A, Hammock, Bruce D, Murphy, Elizabeth, Zeldin, Darryl C

“…Human CYP2J2 is abundant in heart and active in the biosynthesis of epoxyeicosatrienoic acids (EETs); however, the functional role of this P450 and its…”
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Characterization of the Cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis by Wells, Michael A., Vendrov, Kimberly C., Edin, Matthew L., Ferslew, Brian C., Zha, Weibin, Nguyen, Bobbie K.H., Church, Rachel J., Lih, Fred B., DeGraff, Laura M., Brouwer, Kim L.R., Barritt, A. Sidney, Zeldin, Darryl C., Lee, Craig R.

“…•The functional relevance of the CYP epoxyeicosanoid pathway in NASH was evaluated.•Experimental induction of NASH increased hepatic and circulating EET levels…”
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The Chemokine Receptor D6 Has Opposing Effects on Allergic Inflammation and Airway Reactivity by Whitehead, Gregory S, Wang, Tie, DeGraff, Laura M, Card, Jeffrey W, Lira, Sergio A, Graham, Gerard J, Cook, Donald N

“…The D6 chemokine receptor can bind and scavenge several chemokines, including the T-helper 2 (Th2)-associated chemokines CCL17 and CCL22. Although D6 is…”
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Transcriptomic analysis of pathways regulated by toll-like receptor 4 in a murine model of chronic pulmonary inflammation and carcinogenesis by Bauer, Alison K, Fostel, Jennifer, Degraff, Laura M, Rondini, Elizabeth A, Walker, Christopher, Grissom, Sherry F, Foley, Julie, Kleeberger, Steven R

“…Therapeutic strategies exist for human pulmonary neoplasia, however due to the heterogeneity of the disease, most are not very effective. The innate immunity…”
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Male sex hormones promote vagally mediated reflex airway responsiveness to cholinergic stimulation by Card, Jeffrey W, Voltz, James W, Ferguson, Catherine D, Carey, Michelle A, DeGraff, Laura M, Peddada, Shyamal D, Morgan, Daniel L, Zeldin, Darryl C

“…A sex disparity in airway responsiveness to cholinergic stimulation has been observed in laboratory mice in that males are considerably more responsive than…”
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Cyclooxygenase-2 Regulates Th17 Cell Differentiation during Allergic Lung Inflammation by HONG LI, ALYCE BRADBURY, J, COOK, Donald N, TOMER, Kenneth B, JETTEN, Anton M, ZELDIN, Darryl C, DACKOR, Ryan T, EDIN, Matthew L, GRAVES, Joan P, DEGRAFF, Laura M, PING MING WANG, BORTNER, Carl D, MARUOKA, Shuichiro, LIH, Fred B

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Electrophysiological properties of cardiomyocytes isolated from CYP2J2 transgenic mice by Ke, Qingen, Xiao, Yong-Fu, Bradbury, J Alyce, Graves, Joan P, Degraff, Laura M, Seubert, John M, Zeldin, Darryl C

“…CYP2J2 is abundant in cardiac tissue and active in the biosynthesis of eicosanoids such as epoxyeicosatrienoic acids (EETs). To determine the effects of CYP2J2…”
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Disruption of Ephx2 in cardiomyocytes but not endothelial cells improves functional recovery after ischemia-reperfusion in isolated mouse hearts by Edin, Matthew L., Gruzdev, Artiom, Bradbury, J. Alyce, Graves, Joan P., Lih, Fred B., DeGraff, Laura M., Fleming, Ingrid, Zeldin, Darryl C.

“…Cytochromes P450 metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) which have numerous effects. After cardiac ischemia, EET-induced coronary…”
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