Search Results - "Degoul, F"

CPOP: An open source C++ cell POPulation modeler for radiation biology applications by Maigne, L., Delsol, A., Fois, G., Debiton, E., Degoul, F., Payno, H.

“…•New open source C++ platform based on Geant4 for radiation biology.•Modeling of 2D and 3D realistic cell populations.•Simulation of preclinical and clinical…”
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A large-scale RNAi screen identifies LCMR1 as a critical regulator of Tspan8-mediated melanoma invasion by Agaësse, G, Barbollat-Boutrand, L, Sulpice, E, Bhajun, R, Kharbili, M E l, Berthier-Vergnes, O, Degoul, F, de la Fouchardière, A, Berger, E, Voeltzel, T, Lamartine, J, Gidrol, X, Masse, I

“…Melanoma is the deadliest form of skin cancer owing to its proclivity to metastasise, and recently developed therapies have not yielded the expected results,…”
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A large-scale RNAi screen identifies LCMR1 as a critical regulator of Tspan8-mediated melanoma invasion by Agaësse, G, Barbollat-Boutrand, L, Sulpice, E, Bhajun, R, El Kharbili, M, Berthier-Vergnes, O, Degoul, F, de la Fouchardière, A, Berger, E, Voeltzel, T, Lamartine, J, Gidrol, X, Masse, I

“…This corrects the article DOI: 10.1038/onc.2016.219…”
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Characterization of pro-invasive mechanisms and N-terminal cleavage of ANXA1 in melanoma by Boudhraa, Z., Merle, C., Mazzocut, D., Chezal, J. M., Chambon, C., Miot-Noirault, E., Theisen, M., Bouchon, B., Degoul, F.

“…Annexin A1 deregulation is often associated with cancer. Indeed we have shown that annexin A1 is overexpressed in melanoma and promotes metastases by formyl…”
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Internal dosimetry through GATE simulations of preclinical radiotherapy using a melanin-targeting ligand by Perrot, Y, Degoul, F, Auzeloux, P, Bonnet, M, Cachin, F, Chezal, J M, Donnarieix, D, Labarre, P, Moins, N, Papon, J, Rbah-Vidal, L, Vidal, A, Miot-Noirault, E, Maigne, L

“…The GATE Monte Carlo simulation platform based on the Geant4 toolkit is under constant improvement for dosimetric calculations. In this study, we explore its…”
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Alkylation of prohibitin by cyclohexylphenyl‐chloroethyl urea on an aspartyl residue is associated with cell cycle G 1 arrest in B16 cells by Bouchon, B, Papon, J, Communal, Y, Madelmont, J‐C, Degoul, F

“…Background and purpose: Phenyl‐chloroethyl ureas (CEUs) are a class of anticancer drugs that mainly react with proteins. Two molecules of this family,…”
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Homozygosity for alanine in the mitochondrial targeting sequence of superoxide dismutase and risk for severe alcoholic liver disease by Degoul, Françoise, Sutton, Angela, Mansouri, Abdellah, Cepanec, Claude, Degott, Claude, Fromenty, Bernard, Beaugrand, Michel, Valla, Dominique, Pessayre, Dominique

“…Background & Aims: For similar ethanol consumption, a some subjects only develop macrovacuolar steatosis whereas others develop severe liver lesions. A genetic…”
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Alkylation of prohibitin by cyclohexylphenyl-chloroethyl urea on an aspartyl residue is associated with cell cycle G(1) arrest in B16 cells by Bouchon, B, Papon, J, Communal, Y, Madelmont, J-C, Degoul, F

“…Phenyl-chloroethyl ureas (CEUs) are a class of anticancer drugs that mainly react with proteins. Two molecules of this family, cyclohexylphenyl-chloroethyl…”
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The presence of modified nucleotides is required for cloverleaf folding of a human mitochondrial tRNA by Helm, Mark, Brulé, Hervé, Degoul, Françoise, Cepanec, Claude, Leroux, Jean-Paul, Giegé, Richard, Florentz, Catherine

“…Direct sequencing of human mitochondrial tRNALys shows the absence of editing and the occurrence of six modified nucleotides (m1A9, m2G10, Ψ27, Ψ28 and…”
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9303 ORAL 1311 Targeted Radionuclide Therapy by Melanin Linked Molecules for Melanoma Treatment by Degoul, F, Besse, S, Jacquemot, J, Papon, J, Mischellany, F, Cayre, A, Cluzel, J, Chezal, J.M, Moins, N, Bonnet, M

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N-(4-iodophenyl)-N'-(2-chloroethyl)urea as a microtubule disrupter : in vitro and in vivo profiling of antitumoral activity on CT-26 murine colon carcinoma cell line cultured and grafted to mice by BOREL, M, DEGOUL, F, COMMUNAL, Y, MOUNETOU, E, BOUCHON, B, GAUDREAULT, R. C, MADELMONT, J. C, MIOT-NOIRAULT, E

“…The antitumoral profile of the microtubule disrupter N-(4-iodophenyl)-N'-(2-chloroethyl)urea (ICEU) was characterised in vitro and in vivo using the CT-26…”
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Zidovudine myopathy: a distinctive disorder associated with mitochondrial dysfunction by Mhiri, C, Baudrimont, M, Bonne, G, Geny, C, Degoul, F, Marsac, C, Roullet, E, Gherardi, R

“…Muscle biopsy specimens were obtained from 48 human immunodeficiency virus-infected patients suffering from various neuromuscular symptoms. Microscopic…”
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Differential expression of annexin A1 modulates invasion of melanoma B16 cells by Degoul, F, Rondepierre, F, Bouchon, B, Papon, J, Duquennoy, M, Moins, N, Maublant, J, Madelmont, J.C, D'Incan, M

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Isoleucylation Properties of Native Human Mitochondrial tRNAIle and tRNAIle Transcripts. Implications for Cardiomyopathy-Related Point Mutations (4269, 4317) in the tRNAIle Gene by Degoul, F., Brulé, H., Cepanec, C., Helm, M., Marsac, C., Leroux, J.-P., Giegé, R., Florentz, C.

“…A growing number of mutated mitochondrial tRNA genes have been found associated with severe human diseases. To investigate the potential interference of such…”
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Different mechanisms inferred from sequences of human mitochondrial DNA deletions in ocular myopathies by DEGOUL, F, NELSON, I, AMSELEM, S, ROMERO, N, OBERMAIER-KUSSER, B, PONSOT, G, MARSAC, C, LESTIENNE, P

“…We have sequenced the deletion borders of the muscle mitochondrial DNA from 24 patients with heteroplasmic deletions. The length of these deletions varies from…”
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Myo-leukoencephalopathy in twins: study of 3243-myopathy, encephalopathy, lactic acidosis, and strokelike episodes mitochondrial DNA mutation by Degoul, F, Diry, M, Pou-Serradell, A, Lloreta, J, Marsac, C

“…Two dizygotic twins with myopathy and leukoencephalopathy are described. The female twin had an incomplete form of MELAS syndrome (myopathy, encephalopathy,…”
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The manganese superoxide dismutase Ala16Val dimorphism modulates both mitochondrial import and mRNA stability by Sutton, Angela, Imbert, Audrey, Igoudjil, Anissa, Descatoire, Véronique, Cazanave, Sophie, Pessayre, Dominique, Degoul, Françoise

“…A genetic dimorphism incorporates either alanine (Ala) or valine (Val) in the mitochondrial targeting sequence (MTS) of manganese superoxide dismutase (MnSOD)…”
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41 Simulation of the biological effectiveness caused by 65 MeV protons (clinical beam) and carbon-ions by Ali, Y., Beuve, M., Carnicer, A., Débiton, E., Degoul, F., Hérault, J., Smekens, F., Maigne, L.

“…In order to optimize hadron therapy treatments, not only the absorbed dose will be taken in account but the biological consequences on the irradiated cell…”
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Erratum: A large-scale RNAi screen identifies LCMR1 as a critical regulator of Tspan8-mediated melanoma invasion by Agaësse, G, Barbollat-Boutrand, L, Sulpice, E, Bhajun, R, El Kharbili, M, Berthier-Vergnes, O, Degoul, F, de la Fouchardière, A, Berger, E, Voeltzel, T, Lamartine, J, Gidrol, X, Masse, I

“…Correction to: Oncogene (2017) 36, 446–457; doi:10.1038/onc.2016.219; published online 4 July 2016 The author name in the above paper was published…”
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Third International Congress on Human Mitochondrial Pathology (Euromit III): Towards a better understanding of energy metabolism disorders by Possekel, S., Boitier, E., Marsac, C., Degoul, F.

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