Search Results - "Degl'Innocenti, Debora"

Induction of a Proinflammatory Program in Normal Human Thyrocytes by the RET/PTC1 Oncogene by Maria Grazia Borrello, Luisella Alberti, Andrew Fischer, Debora Degl'Innocenti, Cristina Ferrario, Gariboldi, Manuela, Federica Marchesi, Paola Allavena, Greco, Angela, Paola Collini, Silvana Pilotti, Giuliana Cassinelli, Paola Bressan, Laura Fugazzola, Mantovani, Alberto, Pierotti, Marco A.

“…Rearrangements of the RET receptor tyrosine kinase gene generating RET/PTC oncogenes are specific to papillary thyroid carcinoma (PTC), the most frequent…”
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DUSP6/MKP3 is overexpressed in papillary and poorly differentiated thyroid carcinoma and contributes to neoplastic properties of thyroid cancer cells by Degl'Innocenti, Debora, Romeo, Paola, Tarantino, Eva, Sensi, Marialuisa, Cassinelli, Giuliana, Catalano, Veronica, Lanzi, Cinzia, Perrone, Federica, Pilotti, Silvana, Seregni, Ettore, Pierotti, Marco A, Greco, Angela, Borrello, Maria Grazia

“…Thyroid carcinomas derived from follicular cells comprise papillary thyroid carcinoma (PTC), follicular thyroid carcinoma, poorly differentiated thyroid…”
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RET/PTC1-Driven Neoplastic Transformation and Proinvasive Phenotype of Human Thyrocytes Involve Met Induction and β-Catenin Nuclear Translocation by Cassinelli, Giuliana, Favini, Enrica, Degl'Innocenti, Debora, Salvi, Alessandro, De Petro, Giuseppina, Pierotti, Marco A., Zunino, Franco, Borrello, Maria Grazia, Lanzi, Cinzia

“…Activation of the RET gene by chromosomal rearrangements generating RET/PTC oncogenes is a frequent, early, and causative event in papillary thyroid carcinoma…”
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Functional characterization of the MTC-associated germline RET-K666E mutation: evidence of oncogenic potential enhanced by the G691S polymorphism by Borrello, Maria Grazia, Aiello, Antonella, Peissel, Bernard, Rizzetti, Maria Grazia, Mondellini, Piera, Degl'Innocenti, Debora, Catalano, Veronica, Gobbo, Morena, Collini, Paola, Bongarzone, Italia, Pierotti, Marco A, Greco, Angela, Seregni, Ettore

“…Activating mutations of RET, a gene encoding two isoforms of a tyrosine kinase receptor physiologically expressed in several neural crest-derived cell…”
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Integrated ligand-receptor bioinformatic and in vitro functional analysis identifies active TGFA/EGFR signaling loop in papillary thyroid carcinomas by Degl'Innocenti, Debora, Alberti, Chiara, Castellano, Giancarlo, Greco, Angela, Miranda, Claudia, Pierotti, Marco A, Seregni, Ettore, Borrello, Maria Grazia, Canevari, Silvana, Tomassetti, Antonella

“…Papillary thyroid carcinoma (PTCs), the most frequent thyroid cancer, is usually not life threatening, but may recur or progress to aggressive forms resistant…”
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miR-199a-3p displays tumor suppressor functions in papillary thyroid carcinoma by Minna, Emanuela, Romeo, Paola, De Cecco, Loris, Dugo, Matteo, Cassinelli, Giuliana, Pilotti, Silvana, Degl'Innocenti, Debora, Lanzi, Cinzia, Casalini, Patrizia, Pierotti, Marco A, Greco, Angela, Borrello, Maria Grazia

“…Thyroid cancer incidence is rapidly increasing. Papillary Thyroid Carcinoma (PTC), the most frequent hystotype, usually displays good prognosis, but no…”
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The tight relationship between papillary thyroid cancer, autoimmunity and inflammation: clinical and molecular studies by Muzza, Marina, Degl'Innocenti, Debora, Colombo, Carla, Perrino, Michela, Ravasi, Elena, Rossi, Stefania, Cirello, Valentina, Beck-Peccoz, Paolo, Borrello, Maria Grazia, Fugazzola, Laura

“…Summary Objective  The recent concept that oncogenes responsible for thyroid neoplastic transformation are able to elicit an inflammatory protumourigenic…”
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A phase II study on the role of gemcitabine plus romidepsin (GEMRO regimen) in the treatment of relapsed/refractory peripheral T-cell lymphoma patients by Pellegrini, Cinzia, Dodero, Anna, Chiappella, Annalisa, Monaco, Federico, Degl'Innocenti, Debora, Salvi, Flavia, Vitolo, Umberto, Argnani, Lisa, Corradini, Paolo, Zinzani, Pier Luigi

“…There is no consensus regarding optimal treatment for peripheral T-cell lymphomas (PTCL), especially in relapsed or refractory cases, which have very poor…”
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Inflammation and cancer: The oncogene-driven connection by Borrello, Maria Grazia, Degl’Innocenti, Debora, Pierotti, Marco A

“…Abstract Inflammation has long been suspected to contribute to tumor growth. However, the concept that oncogenes, known for decades as responsible for cell…”
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Differential requirement of Tyr1062 multidocking site by RET isoforms to promote neural cell scattering and epithelial cell branching by DEGL'INNOCENTI, Debora, ARIGHI, Elena, POPSUEVA, Anna, SANGREGORIO, Romina, ALBERTI, Luisella, RIZZETTI, Maria Grazia, FERRARIO, Cristina, SARIOLA, Hannu, PIEROTTI, Marco A, BORRELLO, Maria Grazia

“…The receptor tyrosine kinase RET is alternatively spliced to yield two main isoforms, RET9 and RET51, which differ in their carboxyl terminal. Activated RET…”
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Biological Effects of the Dual Phenotypic Janus Mutation of ret Cosegregating with Both Multiple Endocrine Neoplasia Type 2 and Hirschsprung’s Disease by Arighi, Elena, Popsueva, Anna, Degl’Innocenti, Debora, Borrello, Maria Grazia, Carniti, Cristiana, Perälä, Nina M, Pierotti, Marco A, Sariola, Hannu

“…Gain-of-function mutations of ret receptor tyrosine kinase, the signaling receptor for glial cell line-derived neurotrophic factor, cause sporadic thyroid and…”
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RET/PTC1-Driven Neoplastic Transformation and Proinvasive Phenotype of Human Thyrocytes Involve Met Induction and β-Catenin Nuclear Translocation1 by Cassinelli, Giuliana, Favini, Enrica, Degl'Innocenti, Debora, Salvi, Alessandro, De Petro, Giuseppina, Pierotti, Marco A, Zunino, Franco, Borrello, Maria Grazia, Lanzi, Cinzia

“…Activation of the RET gene by chromosomal rearrangements generating RET/PTC oncogenes is a frequent, early, and causative event in papillary thyroid carcinoma…”
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Differential interaction of Enigma protein with the two RET isoforms by Borrello, Maria Grazia, Mercalli, Elena, Perego, Carla, Degl'Innocenti, Debora, Ghizzoni, Simona, Arighi, Elena, Eroini, Barbara, Rizzetti, Maria Grazia, Pierotti, Marco A

“…The receptor tyrosine kinase RET, with a known role in embryonic development and in human pathologies, is alternatively spliced to yield at least two…”
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RET activation in medullary carcinomas by Pierotti, Marco A, Arighi, Elena, Degl'innocenti, Debora, Borrello, Maria Grazia

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The tight relationship between papillary thyroid cancer, autoimmunity and inflammation: clinical and molecular studies by Muzza, Marina, Degl’Innocenti, Debora, Colombo, Carla, Perrino, Michela, Ravasi, Elena, Rossi, Stefania, Cirello, Valentina, Beck-Peccoz, Paolo, Borrello, Maria Grazia, Fugazzola, Laura

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