Search Results - "Degen, David"

Structural basis of ECF-σ-factor-dependent transcription initiation by Lin, Wei, Mandal, Sukhendu, Degen, David, Cho, Min Sung, Feng, Yu, Das, Kalyan, Ebright, Richard H.

“…Extracytoplasmic (ECF) σ factors, the largest class of alternative σ factors, are related to primary σ factors, but have simpler structures, comprising only…”
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Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3) by Lin, Wei, Das, Kalyan, Degen, David, Mazumder, Abhishek, Duchi, Diego, Wang, Dongye, Ebright, Yon W., Ebright, Richard Y., Sineva, Elena, Gigliotti, Matthew, Srivastava, Aashish, Mandal, Sukhendu, Jiang, Yi, Liu, Yu, Yin, Ruiheng, Zhang, Zhening, Eng, Edward T., Thomas, Dennis, Donadio, Stefano, Zhang, Haibo, Zhang, Changsheng, Kapanidis, Achillefs N., Ebright, Richard H.

“…Fidaxomicin is an antibacterial drug in clinical use for treatment of Clostridium difficile diarrhea. The active ingredient of fidaxomicin, lipiarmycin A3…”
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New target for inhibition of bacterial RNA polymerase: ‘switch region’ by Srivastava, Aashish, Talaue, Meliza, Liu, Shuang, Degen, David, Ebright, Richard Y, Sineva, Elena, Chakraborty, Anirban, Druzhinin, Sergey Y, Chatterjee, Sujoy, Mukhopadhyay, Jayanta, Ebright, Yon W, Zozula, Alex, Shen, Juan, Sengupta, Sonali, Niedfeldt, Rui Rong, Xin, Cai, Kaneko, Takushi, Irschik, Herbert, Jansen, Rolf, Donadio, Stefano, Connell, Nancy, Ebright, Richard H

“…Highlights ► Bacterial RNA polymerase is a proven target for antibacterial therapy. ► The ‘switch region’ is a new inhibitor binding site within bacterial RNA…”
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Salinamide F, new depsipeptide antibiotic and inhibitor of bacterial RNA polymerase from a marine-derived Streptomyces sp by Hassan, Hossam M, Degen, David, Jang, Kyoung Hwa, Ebright, Richard H, Fenical, William

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Frequency, Spectrum, and Nonzero Fitness Costs of Resistance to Myxopyronin in Staphylococcus aureus by SRIVASTAVA, Aashish, DEGEN, David, EBRIGHT, Yon W, EBRIGHT, Richard H

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Transcription inhibition by the depsipeptide antibiotic salinamide A by Degen, David, Feng, Yu, Zhang, Yu, Ebright, Katherine Y, Ebright, Yon W, Gigliotti, Matthew, Vahedian-Movahed, Hanif, Mandal, Sukhendu, Talaue, Meliza, Connell, Nancy, Arnold, Eddy, Fenical, William, Ebright, Richard H

“…We report that bacterial RNA polymerase (RNAP) is the functional cellular target of the depsipeptide antibiotic salinamide A (Sal), and we report that Sal…”
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GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides by Zhang, Yu, Degen, David, Ho, Mary X, Sineva, Elena, Ebright, Katherine Y, Ebright, Yon W, Mekler, Vladimir, Vahedian-Movahed, Hanif, Feng, Yu, Yin, Ruiheng, Tuske, Steve, Irschik, Herbert, Jansen, Rolf, Maffioli, Sonia, Donadio, Stefano, Arnold, Eddy, Ebright, Richard H

“…Using a combination of genetic, biochemical, and structural approaches, we show that the cyclic-peptide antibiotic GE23077 (GE) binds directly to the bacterial…”
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Retrieval of aerosol properties from in situ, multi-angle light scattering measurements using invertible neural networks by Boiger, Romana, Modini, Rob L., Moallemi, Alireza, Degen, David, Adelmann, Andreas, Gysel-Beer, Martin

“…Atmospheric aerosols have a major influence on the earth’s climate and public health. Hence, studying their properties and recovering them from light…”
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Total Synthesis of Marformycins A and D by Anwar, Avraz F., Elbatrawi, Yassin M., Degen, David, Ebright, Richard H., Del Valle, Juan R.

“…We report the synthesis of the antimicrobial cyclodepsipeptides marformycin A (1) and marformycin D (2) using a solid-phase approach. A scalable solution-phase…”
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Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition by Lin, Wei, Mandal, Soma, Degen, David, Liu, Yu, Ebright, Yon W., Li, Shengjian, Feng, Yu, Zhang, Yu, Mandal, Sukhendu, Jiang, Yi, Liu, Shuang, Gigliotti, Matthew, Talaue, Meliza, Connell, Nancy, Das, Kalyan, Arnold, Eddy, Ebright, Richard H.

“…Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, which kills 1.8 million annually. Mtb RNA polymerase (RNAP) is the target of the…”
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Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase by Maffioli, Sonia I., Zhang, Yu, Degen, David, Carzaniga, Thomas, Del Gatto, Giancarlo, Serina, Stefania, Monciardini, Paolo, Mazzetti, Carlo, Guglierame, Paola, Candiani, Gianpaolo, Chiriac, Alina Iulia, Facchetti, Giuseppe, Kaltofen, Petra, Sahl, Hans-Georg, Dehò, Gianni, Donadio, Stefano, Ebright, Richard H.

“…Drug-resistant bacterial pathogens pose an urgent public-health crisis. Here, we report the discovery, from microbial-extract screening, of a nucleoside-analog…”
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Total Synthesis of Pargamicin A by Elbatrawi, Yassin M., Gerrein, Taylor, Anwar, Avraz, Makwana, Kamlesh M., Degen, David, Ebright, Richard H., Del Valle, Juan R.

“…We report the total synthesis and configurational assignment of pargamicin A, a highly oxidized nonribosomal peptide that potently inhibits the growth of…”
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Correction to: Salinamide F, new depsipeptide antibiotic and inhibitor of bacterial RNA polymerase from a marine-derived Streptomyces sp by Hassan, Hossam M., Degen, David, Jang, Kyoung Hwa, Ebright, Richard H., Fenical, William

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Stabilizing Pseudouridimycin: Synthesis, RNA Polymerase Inhibitory Activity, and Antibacterial Activity of Dipeptide‐Modified Analogues by Anwar, Avraz F., Cain, Christopher F., Garza, Michael J., Degen, David, Ebright, Richard H., Del Valle, Juan R.

“…Pseudouridimycin (PUM) is a microbially produced C‐nucleoside dipeptide that selectively targets the nucleotide addition site of bacterial RNA polymerase…”
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Front Cover: Stabilizing Pseudouridimycin: Synthesis, RNA Polymerase Inhibitory Activity, and Antibacterial Activity of Dipeptide‐Modified Analogues (ChemMedChem 1/2024) by Anwar, Avraz F., Cain, Christopher F., Garza, Michael J., Degen, David, Ebright, Richard H., Del Valle, Juan R.

“…The Front Cover shows a crystal structure of pseudouridimycin (PUM) bound to T. thermophilus RNA polymerase transcription complex. PUM′s inherent instability…”
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Synthesis and Evaluation of Novel Analogues of Ripostatins by Tang, Wufeng, Liu, Shuang, Degen, David, Ebright, Richard H., Prusov, Evgeny V.

“…Ripostatins are polyene macrolactones isolated from the myxobacterium Sorangium cellulosum. They exhibit antibiotic activity by inhibiting bacterial RNA…”
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Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles by Feng, Yu, Degen, David, Wang, Xinyue, Gigliotti, Matthew, Liu, Shuang, Zhang, Yu, Das, Deepankar, Michalchuk, Trevor, Ebright, Yon W., Talaue, Meliza, Connell, Nancy, Ebright, Richard H.

“…CBR hydroxamidines are small-molecule inhibitors of bacterial RNA polymerase (RNAP) discovered through high-throughput screening of synthetic-compound…”
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On the moduli space of ricci flat metrics on a K3 surface by Degen, David

“…We show that the moduli space of Ricci flat metrics of unit volume (including orbifold metrics) on a K3 surface is simply connected and that it has the same…”
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Affinity Selection–Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor by Walker, Scott S, Degen, David, Nickbarg, Elliott, Carr, Donna, Soriano, Aileen, Mandal, Mihir, Painter, Ronald E, Sheth, Payal, Xiao, Li, Sher, Xinwei, Murgolo, Nicholas, Su, Jing, Olsen, David B, Ebright, Richard H, Young, Katherine

“…The growing prevalence of drug resistant bacteria is a significant global threat to human health. The antibacterial drug rifampin, which functions by…”
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Targets of transcription inhibition by the antibiotics lipiarmycin, GE23077, and salinamide by Degen, David D

“…The antibiotics lipiarmycin (Lpm), GE23077 (GE), and salinamide (Sal) function by inhibiting bacterial RNA polymerase (RNAP). In this work, the targets (and…”
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