Search Results - "Degani, Mariam S."

Microwave-Assisted Development of Orally Disintegrating Tablets by Direct Compression by Kande, Kishor V., Kotak, Darsheen J., Degani, Mariam S., Kirsanov, Dmitry, Legin, Andrey, Devarajan, Padma V.

“…ABSTRACT Orally disintegrating tablets (ODTs) are challenged by the need for simple technology to ensure good mechanical strength coupled with rapid…”
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Tackling SARS-CoV-2: proposed targets and repurposed drugs by Joshi, Siddhi, Joshi, Maithili, Degani, Mariam S

“…The SARS-CoV-2 pandemic, declared as a global health emergency by the WHO in February 2020, has currently infected more than 6 million people with fatalities…”
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A review of molecular modelling studies of dihydrofolate reductase inhibitors against opportunistic microorganisms and comprehensive evaluation of new models by Tawari, Nilesh R, Bag, Seema, Degani, Mariam S

“…Dihydrofolate reductase (DHFR) has been used as a target for antimicrobial drug discovery against a variety of pathogenic microorganisms, including…”
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Design, synthesis and antimycobacterial activity of cinnamide derivatives: A molecular hybridization approach by Kakwani, Manoj D., Suryavanshi, Prashant, Ray, Muktikant, Rajan, M.G.R., Majee, Sharmila, Samad, Abdul, Devarajan, Padma, Degani, Mariam S.

“…A series of cinnamide derivatives was designed as potential antimycobacterial agents using molecular hybridization approach. The synthesized molecules showed…”
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The expanding repertoire of covalent warheads for drug discovery by Mehta, Namrashee V, Degani, Mariam S

“…The reactive functionalities of drugs that engage in covalent interactions with the enzyme/receptor residue in either a reversible or an irreversible manner…”
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Oxadiazole scaffolds in anti-tuberculosis drug discovery by De, Suparna S., Khambete, Mihir P., Degani, Mariam S.

“…[Display omitted] With the increasing number of cases of latent and drug resistant tuberculosis, there is an urgent need to develop new, potent molecules…”
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Elemental exchange: Bioisosteric replacement of phosphorus by boron in drug design by Mehta, Namrashee V., Abhyankar, Arundhati, Degani, Mariam S.

“…Continuous efforts are being directed toward the employment of boron in drug design due to its advantages and unique characteristics including a plethora of…”
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Synthesis and preliminary biological evaluation of novel N-(3-aryl-1,2,4-triazol-5-yl) cinnamamide derivatives as potential antimycobacterial agents: An operational Topliss Tree approach by Kakwani, Manoj D., Palsule Desai, Nutan H., Lele, Arundhati C., Ray, Muktikant, Rajan, M.G.R., Degani, Mariam S.

“…A novel series of N-(3-aryl-1,2,4-triazol-5-yl) cinnamamide derivatives were synthesized as potential antimycobacterial agents. Topliss operational method was…”
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Novel 2-hydrazino-pyrimidin-4(3H)-one derivatives with pseudofunctional- similarity to siderophores as potential antimycobacterial agents by Bairwa, Ranjeet, Tawari, Nilesh R, Alate, Amruta, Anam, Swapnil, Degani, Mariam S, Ray, Muktikant, Rajan, Ramakrishna M G

“…Siderophores are small molecules produced by bacteria under iron-scarcity conditions faced by bacteria inside host. Sideophores bind iron with high affinity…”
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Mutations in SARS‐CoV‐2 nsp7 and nsp8 proteins and their predicted impact on replication/transcription complex structure by Reshamwala, Shamlan M. S., Likhite, Vishakha, Degani, Mariam S., Deb, Shalini S., Noronha, Santosh B.

“…Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) RNA‐dependent RNA polymerase (RdRp) has been identified to be a mutation hot spot, with the P323L…”
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New Schiff Base-Linked Arylazopyrazoles as Reagents for the Photometric Detection of Fluoride Ions by Kumar, Manish, Agarkar, Harshawardhan, Degani, Mariam S.

“…A novel class of reagents (L1–3) containing arylazopyrazole moiety linked to a Schiff base have been synthesized and investigated for anion sensing…”
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Antimicrobial potential of quaternary phosphonium salt compounds: a review by Ibrahim, Mahin K, Haria, Akash, Mehta, Namrashee V, Degani, Mariam S

“…Given that mitochondrial dysregulation is a biomarker of many cancers, cationic quaternary phosphonium salt (QPS) conjugation is a widely utilized strategy for…”
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Synthesis and in-vivo taste assessment of meloxicam pivalate by Chatale, Bandoo C., Degani, Mariam S.

“…Meloxicam (MX), a nonsteroidal anti-inflammatory drug, widely used to treat arthritis, has a very bitter taste. Chemical modification of the bitter…”
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Insights into the Interaction Mechanism of Ligands with Aβ42 Based on Molecular Dynamics Simulations and Mechanics: Implications of Role of Common Binding Site in Drug Design for Alzheimer's Disease by Kundaikar, Harish S., Degani, Mariam S.

“…Aggregation of β‐amyloid (Aβ) into oligomers and further into fibrils is hypothesized to be a key factor in pathology of Alzheimer's disease (AD). In this…”
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Mitochondriotropic Derivative of Ethyl Ferulate, a Dietary Phenylpropanoid, Exhibits Enhanced Cytotoxicity in Cancer Cells via Mitochondrial Superoxide-Mediated Activation of JNK and AKT Signalling by Patil, Ashwani S., Ibrahim, Mahin K., Sathaye, Sadhana, Degani, Mariam S., Pal, Debojyoti, Checker, Rahul, Sharma, Deepak, Sandur, Santosh K.

“…Specific targeting of anti-cancer drugs to mitochondria is an emerging strategy to enhance cancer cell killing whilst simultaneously overcoming the problem of…”
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Pharmacophore based 3DQSAR of phenothiazines as specific human butyrylcholinesterase inhibitors for treatment of Alzheimer's disease by Kundaikar, Harish S, Agre, Neha P, Degani, Mariam S

“…Quantitative three dimensional structure activity relationship (3D-QSAR) studies were performed on phenothiazine derivatives as Butyrylcholinesterase (BuChE)…”
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E84G mutation in dihydrofolate reductase from drug resistant strains of Mycobacterium tuberculosis (Mumbai, India) leads to increased interaction with Trimethoprim by Raju, Archana, Kulkarni, Savita, Ray, M.K, Rajan, M.G.R, Degani, Mariam S

“…Abstract Background Dihydrofolate reductase (DHFR) ( dfrA gene) is an essential enzyme for cell survival and an unexplored target in Mycobacterium tuberculosis…”
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Identification of a novel class of quinoline–oxadiazole hybrids as anti-tuberculosis agents by Jain, Puneet P., Degani, Mariam S., Raju, Archana, Anantram, Aarti, Seervi, Madhav, Sathaye, Sadhana, Ray, Muktikanta, Rajan, M.G.R.

“…[Display omitted] A series of novel quinoline–oxadiazole hybrid compounds was designed based on stepwise rational modification of the lead molecules reported…”
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Polyethylene Glycol Nitrite (PEG-ONO) as a Novel Diazotizing Agent by Bochare, Machhindra D, Degani, Mariam S

“…A polyethylene glycol nitrite (PEG-ONO) has been developed as a novel diazotizing agent. It is found to be a cost-effective, highly stable, easy to handle, and…”
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Antifolate Activity of Plant Polyphenols against Mycobacterium tuberculosis by Raju, Archana, Degani, Mariam S., Khambete, Mihir P., Ray, M. K., Rajan, M. G. R.

“…With the view of exploring phytochemicals as Mycobacterium tuberculosis (Mtb) dihydrofolate reductase inhibitors, known plant polyphenols from various classes…”
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