Search Results - "Degan, Simone"

Closed-Loop extracranial stimulation for enhancing cerebral blood Flow in Alzheimer’s Disease and stroke by Turner, Dennis, Degan, Simone, Schmidt, Stephen

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UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling by Dikshit, Anushka, Jin, Yingai J, Degan, Simone, Hwang, Jihwan, Foster, Matthew W, Li, Chuan-Yuan, Zhang, Jennifer Y

“…UBE2N is a K63-specific ubiquitin conjugase linked to various immune disorders and cancer. Here, we demonstrate that UBE2N and its partners UBE2V1 and UBE2V2…”
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Quantitative 129Xe MRI detects early impairment of gas-exchange in a rat model of pulmonary hypertension by Virgincar, Rohan S., Nouls, John C., Wang, Ziyi, Degan, Simone, Qi, Yi, Xiong, Xinyu, Rajagopal, Sudarshan, Driehuys, Bastiaan

“…Hyperpolarized 129 Xe magnetic resonance imaging (MRI) is capable of regional mapping of pulmonary gas-exchange and has found application in a wide range of…”
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Rapid, Dose-Dependent Enhancement of Cerebral Blood Flow by transcranial AC Stimulation in Mouse by Turner, Dennis A., Degan, Simone, Galeffi, Francesca, Schmidt, Stephen, Peterchev, Angel V.

“…Transcranial electrical stimulation at an appropriate dose may demonstrate intracranial effects, including neuronal stimulation and cerebral blood flow…”
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Corrigendum: Co-treatment of chloroquine and trametinib inhibits melanoma cell proliferation and decreases immune cell infiltration by Degan, Simone, May, Brian L, Jin, Yingai J, Ben Hammouda, Manel, Sun, Huiying, Zhang, Guoqiang, Wang, Yan, Erdmann, Detlev, Warren, Warren, Zhang, Jennifer Y

“…[This corrects the article DOI: 10.3389/fonc.2022.782877.]…”
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Role of hyaluronan and hyaluronan-binding proteins in human asthma by Liang, Jiurong, MD, Jiang, Dianhua, MD, PhD, Jung, Yoosun, MS, Xie, Ting, MD, Ingram, Jennifer, PhD, Church, Tony, BS, Degan, Simone, PhD, Leonard, Maura, BS, Kraft, Monica, MD, Noble, Paul W., MD

“…Background The characteristics of human asthma are chronic inflammation and airway remodeling. Hyaluronan, a major extracellular matrix component, accumulates…”
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Direct detection of brown adipose tissue thermogenesis in UCP1−/− mice by hyperpolarized 129Xe MR thermometry by Antonacci, Michael A., McHugh, Christian, Kelley, Michele, McCallister, Andrew, Degan, Simone, Branca, Rosa T.

“…Brown adipose tissue (BAT) is a type of fat specialized in non-shivering thermogenesis. While non-shivering thermogenesis is mediated primarily by uncoupling…”
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Co-Treatment of Chloroquine and Trametinib Inhibits Melanoma Cell Proliferation and Decreases Immune Cell Infiltration by Degan, Simone, May, Brian L, Jin, Yingai J, Hammoda, Manel Ben, Sun, Huiying, Zhang, Guoqiang, Wang, Yan, Erdmann, Detlev, Warren, Warren, Zhang, Jennifer Y

“…Autophagy is characterized as a cytoprotective process and inhibition of autophagy with medicinally active agents, such as chloroquine (CQ) is proposed as a…”
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In vivo noninvasive detection of Brown Adipose Tissue through intermolecular zero-quantum MRI by Branca, Rosa T, Zhang, Le, Warren, Warren S, Auerbach, Edward, Khanna, Arjun, Degan, Simone, Ugurbil, Kamil, Maronpot, Robert

“…The recent discovery of active Brown Adipose Tissue (BAT) in adult humans has opened new avenues for obesity research and treatment, as reduced BAT activity…”
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Genetic variation in SP-A2 leads to differential binding to Mycoplasma pneumoniae membranes and regulation of host responses by Ledford, Julie G, Voelker, Dennis R, Addison, Kenneth J, Wang, Ying, Nikam, Vinayak S, Degan, Simone, Kandasamy, Pitachaimani, Tanyaratsrisakul, Sasipa, Fischer, Bernard M, Kraft, Monica, Hollingsworth, John W

“…Mycoplasma pneumoniae is an extracellular pathogen that colonizes mucosal surfaces of the respiratory tract and is associated with asthma exacerbations…”
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Airway Fibroblasts in Asthma Manifest an Invasive Phenotype by INGRAM, Jennifer L, HUGGINS, Molly J, SUNDAY, Mary E, NOBLE, Paul W, KRAFT, Monica, CHURCH, Tony D, YUEJUAN LI, FRANCISCO, Dave C, DEGAN, Simone, FIRSZT, Rafael, BEAVER, Denise M, LUGOGO, Njira L, YING WANG

“…Invasive cell phenotypes have been demonstrated in malignant transformation, but not in other diseases, such as asthma. Cellular invasiveness is thought to be…”
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Potential Utility of Synthetic D-Lactate Polymers in Skin Cancer by Dikshit, Anushka, Lu, Junqi, Ford, Amy E., Degan, Simone, Jin, Yingai J., Sun, Huiying, Nichols, Amanda, Salama, April K.S., Beasley, Georgia, Gooden, David, Zhang, Jennifer Y.

“…Increased breakdown of glucose through glycolysis in both aerobic and anaerobic conditions is a hallmark feature of mammalian cancer and leads to increased…”
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NPAS3 is a trachealess homolog critical for lung development and homeostasis by Zhou, Shutang, Degan, Simone, Potts, Erin N, Foster, W. Michael, Sunday, Mary E

“…Trachealess (Trh) is a PAS domain transcription factor regulating Drosophila tracheogenesis. No other Trh homolog has been associated with a respiratory…”
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3D MRI of impaired hyperpolarized 129Xe uptake in a rat model of pulmonary fibrosis by Cleveland, Zackary I., Virgincar, Rohan S., Qi, Yi, Robertson, Scott H., Degan, Simone, Driehuys, Bastiaan

“…A variety of pulmonary pathologies, in particular interstitial lung diseases, are characterized by thickening of the pulmonary blood–gas barrier, and this…”
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Counteracting Signaling Activities in Lipid Rafts Associated with the Invasion of Lung Epithelial Cells by Pseudomonas aeruginosa by Zaas, David W., Swan, Zachary D., Brown, Bethany J., Li, Guojie, Randell, Scott H., Degan, Simone, Sunday, Mary E., Wright, Jo Rae, Abraham, Soman N.

“…Pseudomonas aeruginosa has the capacity to invade lung epithelial cells by co-opting the intrinsic endocytic properties of lipid rafts, which are rich in…”
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Nitric oxide mediates relative airway hyporesponsiveness to lipopolysaccharide in surfactant protein A-deficient mice by Pastva, Amy M, Walker, Julia K L, Maddox, Lee A, Mukherjee, Sambuddho, Giamberardino, Charles, Hsia, Bethany, Potts, Erin, Zhu, Hongmei, Degan, Simone, Sunday, Mary E, Lawson, Barbara L, Korfhagen, Thomas R, Schwartz, David A, Eu, Jerry P, Foster, William M, McMahon, Timothy J, Que, Loretta, Wright, Jo Rae

“…Surfactant protein A (SP-A) mediates innate immune cell responses to LPS, a cell wall component of gram-negative bacteria that is found ubiquitously in the…”
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Optical coherence refraction tomography by Zhou, Kevin C., Qian, Ruobing, Degan, Simone, Farsiu, Sina, Izatt, Joseph A.

“…Optical coherence tomography (OCT) is a cross-sectional, micrometre-scale imaging modality with widespread clinical application. Typical OCT systems sacrifice…”
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c-Kit Is Essential for Alveolar Maintenance and Protection from Emphysema-like Disease in Mice by LINDSEY, James Y, GANGULY, Koustav, STRIPP, Barry R, FOSTER, W. Michael, LEIKAUF, George D, SCHULZ, Holger, HOLLINGSWORTH, John W, BRASS, David M, ZHUOWEI LI, POTTS, Erin N, DEGAN, Simone, HUAIYONG CHEN, BROCKWAY, Brian, ABRAHAM, Soman N, BERNDT, Annerose

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Placement of Extracranial Stimulating Electrodes and Measurement of Cerebral Blood Flow and Intracranial Electrical Fields in Anesthetized Mice by Degan, Simone, Feng, Yu, Hoffmann, Ulrike, Turner, Dennis A

“…The detection of cerebral blood flow (CBF) responses to various forms of neuronal activation is critical for understanding dynamic brain function and…”
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CVN‐AD Alzheimer's mice show premature reduction in neurovascular coupling in response to spreading depression and anoxia compared to aged controls by Turner, Dennis A., Degan, Simone, Hoffmann, Ulrike, Galeffi, Francesca, Colton, Carol A.

“…We compared the efficacy of neurovascular coupling and substrate supply in cerebral cortex during severe metabolic challenges in transgenic Alzheimer's…”
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