Search Results - "Deforche, Louis"

Conformational activation of ADAMTS13 by South, Kieron, Luken, Brenda M., Crawley, James T. B., Phillips, Rebecca, Thomas, Mari, Collins, Richard F., Deforche, Louis, Vanhoorelbeke, Karen, Lane, David A.

“…Significance We show that a CUB–spacer domain interaction impedes exposure of the ADAMTS13 spacer functional exosite, preventing ADAMTS13 from interacting…”
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Allosteric activation of ADAMTS13 by von Willebrand factor by Muia, Joshua, Zhu, Jian, Gupta, Garima, Haberichter, Sandra L., Friedman, Kenneth D., Feys, Hendrik B., Deforche, Louis, Vanhoorelbeke, Karen, Westfield, Lisa A., Roth, Robyn, Tolia, Niraj Harish, Heuser, John E., Sadler, J. Evan

“…Significance The blood protein von Willebrand factor (VWF) is required for platelets to stop bleeding at sites of injury, and the metalloprotease ADAMTS13…”
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Generation of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura by Deforche, Louis, Tersteeg, Claudia, Roose, Elien, Vandenbulcke, Aline, Vandeputte, Nele, Pareyn, Inge, De Cock, Elien, Rottensteiner, Hanspeter, Deckmyn, Hans, De Meyer, Simon F, Vanhoorelbeke, Karen

“…Thrombotic thrombocytopenic purpura (TTP) is a life-threatening thrombotic microangiopathy linked to a deficiency in the metalloprotease ADAMTS13. In the…”
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Anti-ADAMTS13 Antibodies and a Novel Heterozygous p.R1177Q Mutation in a Case of Pregnancy-Onset Immune-Mediated Thrombotic Thrombocytopenic Purpura by Roose, Elien, Tersteeg, Claudia, Demeersseman, Ruth, Schelpe, An-Sofie, Deforche, Louis, Pareyn, Inge, Vandenbulcke, Aline, Vandeputte, Nele, Dierickx, Daan, Voorberg, Jan, Deckmyn, Hans, De Meyer, Simon F, Vanhoorelbeke, Karen

“…In this study, we investigated a case of pregnancy-onset thrombotic thrombocytopenic purpura (TTP). The patient had severely decreased ADAMTS13 ( isintegrin nd…”
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The Hunt for the "Minimal" Structure of a Functional ADAMTS13: Study of Deletion Mutations of ADAMTS13 By Small-Angle X-Ray Scattering by Zhu, Jian, Muia, Joshua, Deforche, Louis, Vanhoorelbeke, Karen, Tolia, Niraj H., Sadler, J. Evan

“…Introduction: ADAMTS13 is a multidomain protein with metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C) and spacer (S) domains,…”
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Phylogenetic Analysis Identifies a Subset of ADAMTS13 Domains That Are Highly Conserved and Essential for Allosteric Regulation by Muia, Joshua, Zhu, Jian, Greco, Suellen, Vanhoorelbeke, Karen, Deforche, Louis, Westfield, Lisa, Tyagi, Garima, Sadler, J. Evan

“…Introduction: Human ADAMTS13 has metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C) and spacer (S) domains (proximal domains),…”
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FRETS-VWF73 rather than CBA assay reflects ADAMTS13 proteolytic activity in acquired thrombotic thrombocytopenic purpura patients by Mancini, I, Valsecchi, C, Lotta, L A, Deforche, L, Pontiggia, S, Bajetta, M, Palla, R, Vanhoorelbeke, K, Peyvandi, F

“…Collagen-binding activity (CBA) and FRETS-VWF73 assays are widely adopted methods for the measurement of the plasmatic activity of ADAMTS13, the von Willebrand…”
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