Search Results - "Defelipe, Javier"

From the Connectome to the Synaptome: An Epic Love Story by DeFelipe, Javier

“…A major challenge in neuroscience is to decipher the structural layout of the brain. The term "connectome" has recently been proposed to refer to the highly…”
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Neuroanatomical data collection and usability by DeFelipe, Javier

“…In other words, the reliability of the data varies. [...]we need to have a deep understanding of the techniques and experimental design used to obtain the…”
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Manifesto of a neuroanatomist by DeFelipe, Javier

“…[...]at the electron microscopy level, our mission is to quantitatively analyze key ultrastructural characteristics of axonal and dendritic processes (e.g.,…”
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The evolution of the brain, the human nature of cortical circuits, and intellectual creativity by Defelipe, Javier

“…The tremendous expansion and the differentiation of the neocortex constitute two major events in the evolution of the mammalian brain. The increase in size and…”
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Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology by Maestú, Fernando, de Haan, Willem, Busche, Marc Aurel, DeFelipe, Javier

“…•The E/I balance is a fundamental mechanism for maintaining effective neuronal communication and support cognitive performance.•AD research has been approached…”
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Pyramidal cell axon initial segment in Alzheimer´s disease by Antón-Fernández, Alejandro, León-Espinosa, Gonzalo, DeFelipe, Javier, Muñoz, Alberto

“…The axon initial segment (AIS) is a region of the neuron that is critical for action potential generation as well as for the regulation of neural activity…”
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Empathy and the art of Leonardo da Vinci by Mansur, Samira Schultz, DeFelipe, Javier

“…Knowledge about empathy is part of the study of artistic expressions, among which stand out works of personalities such as the Renaissance polymath Leonardo da…”
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Three-dimensional synaptic organization of the human hippocampal CA1 field by Montero-Crespo, Marta, Dominguez-Alvaro, Marta, Rondon-Carrillo, Patricia, Alonso-Nanclares, Lidia, DeFelipe, Javier, Blazquez-Llorca, Lidia

“…The hippocampal CA1 field integrates a wide variety of subcortical and cortical inputs, but its synaptic organization in humans is still unknown due to the…”
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Estimation of the number of synapses in the hippocampus and brain-wide by volume electron microscopy and genetic labeling by Santuy, Andrea, Tomás-Roca, Laura, Rodríguez, José-Rodrigo, González-Soriano, Juncal, Zhu, Fei, Qiu, Zhen, Grant, Seth G. N., DeFelipe, Javier, Merchan-Perez, Angel

“…Determining the number of synapses that are present in different brain regions is crucial to understand brain connectivity as a whole. Membrane-associated…”
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Unique membrane properties and enhanced signal processing in human neocortical neurons by Eyal, Guy, Verhoog, Matthijs B, Testa-Silva, Guilherme, Deitcher, Yair, Lodder, Johannes C, Benavides-Piccione, Ruth, Morales, Juan, DeFelipe, Javier, de Kock, Christiaan Pj, Mansvelder, Huibert D, Segev, Idan

“…The advanced cognitive capabilities of the human brain are often attributed to our recently evolved neocortex. However, it is not known whether the basic…”
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Differential Structure of Hippocampal CA1 Pyramidal Neurons in the Human and Mouse by Benavides-Piccione, Ruth, Regalado-Reyes, Mamen, Fernaud-Espinosa, Isabel, Kastanauskaite, Asta, Tapia-González, Silvia, León-Espinosa, Gonzalo, Rojo, Concepcion, Insausti, Ricardo, Segev, Idan, DeFelipe, Javier

“…Abstract Pyramidal neurons are the most common cell type and are considered the main output neuron in most mammalian forebrain structures. In terms of…”
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Age-based comparison of human dendritic spine structure using complete three-dimensional reconstructions by Benavides-Piccione, Ruth, Fernaud-Espinosa, Isabel, Robles, Victor, Yuste, Rafael, DeFelipe, Javier

“…Dendritic spines of pyramidal neurons are targets of most excitatory synapses in the cerebral cortex. Recent evidence suggests that the morphology of the…”
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Dendritic spines are lost in clusters in Alzheimer’s disease by Mijalkov, Mite, Volpe, Giovanni, Fernaud-Espinosa, Isabel, DeFelipe, Javier, Pereira, Joana B., Merino-Serrais, Paula

“…Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a deterioration of neuronal connectivity. The pathological accumulation…”
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Secretagogin as a marker to distinguish between different neuron types in human frontal and temporal cortex by Tapia-González, Silvia, DeFelipe, Javier

“…The principal aim of the present work was to chemically characterize the population of neurons labeled for the calcium binding protein secretagogin (SCGN) in…”
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High levels of 27-hydroxycholesterol results in synaptic plasticity alterations in the hippocampus by Loera-Valencia, Raul, Vazquez-Juarez, Erika, Muñoz, Alberto, Gerenu, Gorka, Gómez-Galán, Marta, Lindskog, Maria, DeFelipe, Javier, Cedazo-Minguez, Angel, Merino-Serrais, Paula

“…Alterations in brain cholesterol homeostasis in midlife are correlated with a higher risk of developing Alzheimer’s disease (AD). However, global…”
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Volume Electron Microscopy Study of the Relationship Between Synapses and Astrocytes in the Developing Rat Somatosensory Cortex by Kikuchi, Toko, Gonzalez-Soriano, Juncal, Kastanauskaite, Asta, Benavides-Piccione, Ruth, Merchan-Perez, Angel, DeFelipe, Javier, Blazquez-Llorca, Lidia

“…Abstract In recent years, numerous studies have shown that astrocytes play an important role in neuronal processing of information. One of the most interesting…”
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Quantitative 3D Ultrastructure of Thalamocortical Synapses from the "Lemniscal" Ventral Posteromedial Nucleus in Mouse Barrel Cortex by Rodriguez-Moreno, Javier, Rollenhagen, Astrid, Arlandis, Jaime, Santuy, Andrea, Merchan-Pérez, Angel, DeFelipe, Javier, Lübke, Joachim H R, Clasca, Francisco

“…Abstract Thalamocortical synapses from "lemniscal" neurons of the dorsomedial portion of the rodent ventral posteromedial nucleus (VPMdm) are able to induce…”
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A biologically inspired repair mechanism for neuronal reconstructions with a focus on human dendrites by Groden, Moritz, Moessinger, Hannah M, Schaffran, Barbara, DeFelipe, Javier, Benavides-Piccione, Ruth, Cuntz, Hermann, Jedlicka, Peter

“…Investigating and modelling the functionality of human neurons remains challenging due to the technical limitations, resulting in scarce and incomplete 3D…”
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A calcium-based plasticity model for predicting long-term potentiation and depression in the neocortex by Chindemi, Giuseppe, Abdellah, Marwan, Amsalem, Oren, Benavides-Piccione, Ruth, Delattre, Vincent, Doron, Michael, Ecker, András, Jaquier, Aurélien T., King, James, Kumbhar, Pramod, Monney, Caitlin, Perin, Rodrigo, Rössert, Christian, Tuncel, Anil M., Van Geit, Werner, DeFelipe, Javier, Graupner, Michael, Segev, Idan, Markram, Henry, Muller, Eilif B.

“…Pyramidal cells (PCs) form the backbone of the layered structure of the neocortex, and plasticity of their synapses is thought to underlie learning in the…”
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Editorial: Sex differences in the brain by Garcia-Segura, Luis Miguel, DeFelipe, Javier

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