Search Results - "Defaus, Sira"

1988–2018: Thirty years of drug smuggling at the nano scale. Challenges and opportunities of cell-penetrating peptides in biomedical research by Gallo, Maria, Defaus, Sira, Andreu, David

“…In 1988, two unrelated papers reported the discovery of peptide vectors with innate cell translocation properties, setting the ground for a new area of…”
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Hitchhiking with Nature: Snake Venom Peptides to Fight Cancer and Superbugs by Pérez-Peinado, Clara, Defaus, Sira, Andreu, David

“…For decades, natural products in general and snake venoms (SV) in particular have been a rich source of bioactive compounds for drug discovery, and they remain…”
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In Vivo Sustained Release of Peptide Vaccine Mediated by Dendritic Mesoporous Silica Nanocarriers by An, Weiteng, Defaus, Sira, Andreu, David, Rivera-Gil, Pilar

“…Mesoporous silica nanoparticles have drawn increasing attention as promising candidates in vaccine delivery. Previous studies evaluating silica-based vaccine…”
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Disrupting GPCR Complexes with Smart Drug-like Peptides by Gallo, Maria, Defaus, Sira, Andreu, David

“…G protein-coupled receptors (GPCRs) are a superfamily of proteins classically described as monomeric transmembrane (TM) receptors. However, increasing evidence…”
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Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects by Gallo, Maria, Moreno, Estefanía, Defaus, Sira, Ortega-Alvaro, Antonio, Gonzalez, Angel, Robledo, Patricia, Cavaco, Marco, Neves, Vera, Castanho, Miguel A. R. B, Casadó, Vicent, Pardo, Leonardo, Maldonado, Rafael, Andreu, David

“…The activation of cannabinoid CB1 receptors (CB1R) by Δ9-tetrahydrocannabinol (THC), the main component of Cannabis sativa, induces analgesia. CB1R activation,…”
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Topoisomeric Membrane-Active Peptides: A Review of the Last Two Decades by Carrera-Aubesart, Adam, Gallo, Maria, Defaus, Sira, Todorovski, Toni, Andreu, David

“…In recent decades, bioactive peptides have been gaining recognition in various biomedical areas, such as intracellular drug delivery (cell-penetrating…”
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Evaluation of Computationally Designed Peptides against TWEAK, a Cytokine of the Tumour Necrosis Factor Ligand Family by Badia-Villanueva, Miriam, Defaus, Sira, Foj, Ruben, Andreu, David, Oliva, Baldo, Sierra, Angels, Fernandez-Fuentes, Narcis

“…The tumour necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the tumour necrosis factor ligand family and has been shown to be…”
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Swine T-Cells and Specific Antibodies Evoked by Peptide Dendrimers Displaying Different FMDV T-Cell Epitopes by de León, Patricia, Cañas-Arranz, Rodrigo, Defaus, Sira, Torres, Elisa, Forner, Mar, Bustos, María J, Revilla, Concepción, Dominguez, Javier, Andreu, David, Blanco, Esther, Sobrino, Francisco

“…Dendrimeric peptide constructs based on a lysine core that comprises both B- and T-cell epitopes of foot-and-mouth disease virus (FMDV) have proven a…”
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Immunogenicity of Foot-and-Mouth Disease Virus Dendrimer Peptides: Need for a T-Cell Epitope and Ability to Elicit Heterotypic Responses by Cañas-Arranz, Rodrigo, de León, Patricia, Defaus, Sira, Torres, Elisa, Forner, Mar, Bustos, María J., Andreu, David, Blanco, Esther, Sobrino, Francisco

“…An approach based on a dendrimer display of B- and T-cell epitopes relevant for antibody induction has been shown to be effective as a foot-and-mouth disease…”
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Development of a Dendrimeric Peptide-Based Approach for the Differentiation of Animals Vaccinated with FlagT4G against Classical Swine Fever from Infected Pigs by Bohórquez, José Alejandro, Defaus, Sira, Rosell, Rosa, Pérez-Simó, Marta, Alberch, Mònica, Gladue, Douglas P, Borca, Manuel V, Andreu, David, Ganges, Llilianne

“…Classical swine fever virus (CSFV) causes a viral disease of high epidemiological and economical significance that affects domestic and wild swine. Control of…”
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Lectin-Binding Specificity of the Fertilization-Relevant Protein PDC-109 by Means of Surface Plasmon Resonance and Carbohydrate REcognition Domain EXcision-Mass Spectrometry by Defaus, Sira, Avilés, Manuel, Andreu, David, Gutiérrez-Gallego, Ricardo

“…Seminal plasma proteins are relevant for sperm functionality and some appear responsible for establishing sperm interactions with the various environments…”
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Peptide-Based Vaccines: Foot-and-Mouth Disease Virus, a Paradigm in Animal Health by ner, Mar, Cañas-Arranz, Rodrigo, Defaus, Sira, de León, Patricia, Rodríguez-Pulido, Miguel, Ganges, Llilianne, Blanco, Esther, Sobrino, Francisco, Andreu, David

“…Vaccines are considered one of the greatest global health achievements, improving the welfare of society by saving lives and substantially reducing the burden…”
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Insights into the Membranolytic Activity of Antimalarial Drug-Cell Penetrating Peptide Conjugates by Aguiar, Luísa, Pinheiro, Marina, Neves, Ana Rute, Vale, Nuno, Defaus, Sira, Andreu, David, Reis, Salette, Gomes, Paula

“…Conjugation of TP10, a cell-penetrating peptide with intrinsic antimalarial activity, to the well-known antimalarial drugs chloroquine and primaquine has been…”
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Examining Topoisomers of a Snake-Venom-Derived Peptide for Improved Antimicrobial and Antitumoral Properties by Carrera-Aubesart, Adam, Defaus, Sira, Pérez-Peinado, Clara, Sandín, Daniel, Torrent, Marc, Jiménez, Maria Ángeles, Andreu, David

“…Ctn[15-34], the C-terminal section of crotalicidin (Ctn), a cathelicidin from a South American pit viper, is an antimicrobial and antitumoral peptide with…”
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A Single Dose of Dendrimer B2T Peptide Vaccine Partially Protects Pigs against Foot-and-Mouth Disease Virus Infection by Cañas-Arranz, Rodrigo, Forner, Mar, Defaus, Sira, de León, Patricia, Bustos, María J., Torres, Elisa, Sobrino, Francisco, Andreu, David, Blanco, Esther

“…Foot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hoofed animals whose control relies on efficient vaccination. We have reported…”
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Immunogenicity of a Dendrimer B2T Peptide Harboring a T-Cell Epitope From FMDV Non-structural Protein 3D by Cañas-Arranz, Rodrigo, de León, Patricia, Forner, Mar, Defaus, Sira, Bustos, María J., Torres, Elisa, Andreu, David, Blanco, Esther, Sobrino, Francisco

“…Synthetic dendrimer peptides are a promising strategy to develop new FMD vaccines. A dendrimer peptide, termed B 2 T-3A, which harbors two copies of the major…”
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Targeting Zika virus with new brain- and placenta-crossing peptide–porphyrin conjugates by Todorovski, Toni, Mendonça, Diogo, Fernandes-Siqueira, Lorena O., Cruz-Oliveira, Christine, Guida, Giuseppina, Valle, Javier, Cavaco, Marco, Limas, Fernanda I. V., Neves, Vera, cadima couto, carla iris, Defaus, Sira, Veiga, Ana Salome, Da Poian, Andrea T., Castanho, Miguel, Andreu, David

“…© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative…”
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Designing Functionally Versatile, Highly Immunogenic Peptide-Based Multiepitopic Vaccines against Foot-and-Mouth Disease Virus by Defaus, Sira, Forner, Mar, Cañas-Arranz, Rodrigo, de León, Patricia, Bustos, María J., Rodríguez-Pulido, Miguel, Blanco, Esther, Sobrino, Francisco, Andreu, David

“…A broadly protective and biosafe vaccine against foot-and-mouth disease virus (FMDV) remains an unmet need in the animal health sector. We have previously…”
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Association of Porcine Swine Leukocyte Antigen (SLA) Haplotypes with B- and T-Cell Immune Response to Foot-and-Mouth Disease Virus (FMDV) Peptides by de León, Patricia, Cañas-Arranz, Rodrigo, Saez, Yago, Forner, Mar, Defaus, Sira, Cuadra, Dolores, Bustos, María J., Torres, Elisa, Andreu, David, Blanco, Esther, Sobrino, Francisco, Hammer, Sabine E.

“…Dendrimer peptides are promising vaccine candidates against the foot-and-mouth disease virus (FMDV). Several B-cell epitope (B2T) dendrimers, harboring a major…”
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Peptide-Based Multiepitopic Vaccine Platforms via Click Reactions by Forner, Mar, Defaus, Sira, Andreu, David

“…Multimeric antigen display and high overall valency are increasingly regarded as strategic goals for potent and broadly efficacious synthetic vaccines with…”
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