Search Results - "Deerlin, Vivianna"

Stages of pTDP-43 pathology in amyotrophic lateral sclerosis by Brettschneider, Johannes, Del Tredici, Kelly, Toledo, Jon B., Robinson, John L., Irwin, David J., Grossman, Murray, Suh, EunRan, Van Deerlin, Vivianna M., Wood, Elisabeth M., Baek, Young, Kwong, Linda, Lee, Edward B., Elman, Lauren, McCluskey, Leo, Fang, Lubin, Feldengut, Simone, Ludolph, Albert C., Lee, Virginia M.-Y., Braak, Heiko, Trojanowski, John Q.

“…Objective To see whether the distribution patterns of phosphorylated 43kDa TAR DNA‐binding protein (pTDP‐43) intraneuronal inclusions in amyotrophic lateral…”
Get full text

GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease by Mata, Ignacio F., Leverenz, James B., Weintraub, Daniel, Trojanowski, John Q., Chen-Plotkin, Alice, Van Deerlin, Vivianna M., Ritz, Beate, Rausch, Rebecca, Factor, Stewart A., Wood-Siverio, Cathy, Quinn, Joseph F., Chung, Kathryn A., Peterson-Hiller, Amie L., Goldman, Jennifer G., Stebbins, Glenn T., Bernard, Bryan, Espay, Alberto J., Revilla, Fredy J., Devoto, Johnna, Rosenthal, Liana S., Dawson, Ted M., Albert, Marilyn S., Tsuang, Debby, Huston, Haley, Yearout, Dora, Hu, Shu-Ching, Cholerton, Brenna A., Montine, Thomas J., Edwards, Karen L., Zabetian, Cyrus P.

“…ABSTRACT Background Loss‐of‐function mutations in the GBA gene are associated with more severe cognitive impairment in PD, but the nature of these deficits is…”
Get full text

C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD by Liu, Elaine Y., Russ, Jenny, Wu, Kathryn, Neal, Donald, Suh, Eunran, McNally, Anna G., Irwin, David J., Van Deerlin, Vivianna M., Lee, Edward B.

“…Hexanucleotide repeat expansions of C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal degeneration. The mutation is…”
Get full text

Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD) by Brettschneider, Johannes, Del Tredici, Kelly, Irwin, David J., Grossman, Murray, Robinson, John L., Toledo, Jon B., Fang, Lubin, Van Deerlin, Vivianna M., Ludolph, Albert C., Lee, Virginia M.-Y., Braak, Heiko, Trojanowski, John Q.

“…We examined regional distribution patterns of phosphorylated 43-kDa TAR DNA-binding protein (pTDP-43) intraneuronal inclusions in frontotemporal lobar…”
Get full text

TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord by Brettschneider, Johannes, Arai, Kimihito, Del Tredici, Kelly, Toledo, Jon B., Robinson, John L., Lee, Edward B., Kuwabara, Satoshi, Shibuya, Kazumoto, Irwin, David J., Fang, Lubin, Van Deerlin, Vivianna M., Elman, Lauren, McCluskey, Leo, Ludolph, Albert C., Lee, Virginia M.-Y., Braak, Heiko, Trojanowski, John Q.

“…We examined the phosphorylated 43-kDa TAR DNA-binding protein (pTDP-43) inclusions as well as neuronal loss in full-length spinal cords and five selected…”
Get full text

Microglial activation correlates with disease progression and upper motor neuron clinical symptoms in amyotrophic lateral sclerosis by Brettschneider, Johannes, Toledo, Jon B, Van Deerlin, Vivianna M, Elman, Lauren, McCluskey, Leo, Lee, Virginia M-Y, Trojanowski, John Q

“…We evaluated clinicopathological correlates of upper motor neuron (UMN) damage in amyotrophic lateral sclerosis (ALS), and analyzed if the presence of the…”
Get full text

Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated by Robinson, John L, Lee, Edward B, Xie, Sharon X, Rennert, Lior, Suh, EunRan, Bredenberg, Colin, Caswell, Carrie, Van Deerlin, Vivianna M, Yan, Ning, Yousef, Ahmed, Hurtig, Howard I, Siderowf, Andrew, Grossman, Murray, McMillan, Corey T, Miller, Bruce, Duda, John E, Irwin, David J, Wolk, David, Elman, Lauren, McCluskey, Leo, Chen-Plotkin, Alice, Weintraub, Daniel, Arnold, Steven E, Brettschneider, Johannes, Lee, Virginia M.-Y, Trojanowski, John Q

“…See Coulthard and Love (doi:10.1093/brain/awy153) for a scientific commentary on this article. The burden of co-pathologies across neurodegenerative diseases…”
Get full text

Trial of Transplantation of HCV-Infected Kidneys into Uninfected Recipients by Goldberg, David S, Abt, Peter L, Blumberg, Emily A, Van Deerlin, Vivianna M, Levine, Matthew, Reddy, K. Rajender, Bloom, Roy D, Nazarian, Susanna M, Sawinski, Deirdre, Porrett, Paige, Naji, Ali, Hasz, Richard, Suplee, Lawrence, Trofe-Clark, Jennifer, Sicilia, Anna, McCauley, Maureen, Farooqi, Midhat, Gentile, Caren, Smith, Jennifer, Reese, Peter P

“…An open-label pilot trial involving 10 patients shows that hepatitis C virus genotype 1–infected kidneys transplanted into HCV-negative recipients, followed by…”
Get full text

APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer’s disease by Nguyen, Aivi T., Wang, Kui, Hu, Gang, Wang, Xuran, Miao, Zhen, Azevedo, Joshua A., Suh, EunRan, Van Deerlin, Vivianna M., Choi, David, Roeder, Kathryn, Li, Mingyao, Lee, Edward B.

“…Beta-amyloid deposition is a defining feature of Alzheimer’s disease (AD). How genetic risk factors, like APOE and TREM2 , intersect with cellular responses to…”
Get full text

Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis by Irwin, David J, Dr, Grossman, Murray, MD, Weintraub, Daniel, MD, Hurtig, Howard I, MD, Duda, John E, MD, Xie, Sharon X, PhD, Lee, Edward B, MD, Van Deerlin, Vivianna M, MD, Lopez, Oscar L, MD, Kofler, Julia K, MD, Nelson, Peter T, MD, Jicha, Gregory A, MD, Woltjer, Randy, MD, Quinn, Joseph F, MD, Kaye, Jeffery, MD, Leverenz, James B, MD, Tsuang, Debby, MD, Longfellow, Katelan, MD, Yearout, Dora, BS, Kukull, Walter, PhD, Keene, C Dirk, MD, Montine, Thomas J, MD, Zabetian, Cyrus P, MD, Trojanowski, John Q, MD

“…Summary Background Great heterogeneity exists in survival and the interval between onset of motor symptoms and dementia symptoms across synucleinopathies. We…”
Get full text

The development and convergence of co-pathologies in Alzheimer's disease by Robinson, John L, Richardson, Hayley, Xie, Sharon X, Suh, EunRan, Van Deerlin, Vivianna M, Alfaro, Brian, Loh, Nicholas, Porras-Paniagua, Matias, Nirschl, Jeffrey J, Wolk, David, Lee, Virginia M-Y, Lee, Edward B, Trojanowski, John Q

“…Cerebral amyloid angiopathy (CAA), limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) and Lewy bodies occur in the absence…”
Get full text

Pathological α-synuclein distribution in subjects with coincident Alzheimer’s and Lewy body pathology by Toledo, Jon B., Gopal, Pallavi, Raible, Kevin, Irwin, David J., Brettschneider, Johannes, Sedor, Samantha, Waits, Kayla, Boluda, Susana, Grossman, Murray, Van Deerlin, Vivianna M., Lee, Edward B., Arnold, Steven E., Duda, John E., Hurtig, Howard, Lee, Virginia M.-Y., Adler, Charles H., Beach, Thomas G., Trojanowski, John Q.

“…We investigated the distribution patterns of Lewy body-related pathology (LRP) and the effect of coincident Alzheimer disease (AD) pathology using a…”
Get full text

Tau immunotherapy is associated with glial responses in FTLD-tau by Kim, Boram, Mikytuck, Bailey, Suh, Eunran, Gibbons, Garrett S., Van Deerlin, Vivianna M., Vaishnavi, Sanjeev N., Spindler, Meredith A., Massimo, Lauren, Grossman, Murray, Trojanowski, John Q., Irwin, David J., Lee, Edward B.

“…Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are neuropathologic subtypes of frontotemporal lobar degeneration with tau inclusions…”
Get full text

Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau by Darwich, Nabil F, Phan, Jessica M, Kim, Boram, Suh, EunRan, Papatriantafyllou, John D, Changolkar, Lakshmi, Nguyen, Aivi T, O'Rourke, Caroline M, He, Zhuohao, Porta, Sílvia, Gibbons, Garrett S, Luk, Kelvin C, Papageorgiou, Sokratis G, Grossman, Murray, Massimo, Lauren, Irwin, David J, McMillan, Corey T, Nasrallah, Ilya M, Toro, Camilo, Aguirre, Geoffrey K, Van Deerlin, Vivianna M, Lee, Edward B

“…Neurodegeneration in Alzheimer's disease (AD) is closely associated with the accumulation of pathologic tau aggregates in the form of neurofibrillary tangles…”
Get full text

Twelve-Month Outcomes After Transplant of Hepatitis C-Infected Kidneys Into Uninfected Recipients: A Single-Group Trial by Reese, Peter P, Abt, Peter L, Blumberg, Emily A, Van Deerlin, Vivianna M, Bloom, Roy D, Potluri, Vishnu S, Levine, Matthew, Porrett, Paige, Sawinski, Deirdre, Nazarian, Susanna M, Naji, Ali, Hasz, Richard, Suplee, Lawrence, Trofe-Clark, Jennifer, Sicilia, Anna, McCauley, Maureen, Gentile, Caren, Smith, Jennifer, Niknam, Bijan A, Bleicher, Melissa, Reddy, K Rajender, Goldberg, David S

“…Organs from hepatitis C virus (HCV)-infected deceased donors are often discarded. Preliminary data from 2 small trials, including THINKER-1 (Transplanting…”
Get full text

Hypermethylation of repeat expanded C9orf72 is a clinical and molecular disease modifier by Russ, Jenny, Liu, Elaine Y., Wu, Kathryn, Neal, Donald, Suh, EunRan, Irwin, David J., McMillan, Corey T., Harms, Matthew B., Cairns, Nigel J., Wood, Elisabeth M., Xie, Sharon X., Elman, Lauren, McCluskey, Leo, Grossman, Murray, Van Deerlin, Vivianna M., Lee, Edward B.

“…C9orf72 promoter hypermethylation inhibits the accumulation of pathologies which have been postulated to be neurotoxic. We tested here whether C9orf72…”
Get full text

Primary Tau Pathology, Not Copathology, Correlates With Clinical Symptoms in PSP and CBD by Robinson, John L, Yan, Ning, Caswell, Carrie, Xie, Sharon X, Suh, EunRan, Van Deerlin, Vivianna M, Gibbons, Garrett, Irwin, David J, Grossman, Murray, Lee, Edward B, Lee, Virginia M -Y, Miller, Bruce, Trojanowski, John Q

“…Abstract Distinct neuronal and glial tau pathologies define corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP). Additional Alzheimer…”
Get full text

Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease by Uemura, Maiko T., Robinson, John L., Cousins, Katheryn A. Q., Tropea, Thomas F., Kargilis, Daniel C., McBride, Jennifer D., Suh, EunRan, Xie, Sharon X., Xu, Yan, Porta, Sílvia, Uemura, Norihito, Van Deerlin, Vivianna M., Wolk, David A., Irwin, David J., Brunden, Kurt R., Lee, Virginia M.-Y., Lee, Edward B., Trojanowski, John Q.

“…Limbic-predominant age-related TDP-43 encephalopathy (LATE) is characterized by the accumulation of TAR-DNA-binding protein 43 (TDP-43) aggregates in older…”
Get full text

T cell lymphoma and secondary primary malignancy risk after commercial CAR T cell therapy by Ghilardi, Guido, Fraietta, Joseph A., Gerson, James N., Van Deerlin, Vivianna M., Morrissette, Jennifer J. D., Caponetti, Gabriel C., Paruzzo, Luca, Harris, Jaryse C., Chong, Elise A., Susanibar Adaniya, Sandra P., Svoboda, Jakub, Nasta, Sunita D., Ugwuanyi, Ositadimma H., Landsburg, Daniel J., Fardella, Eugenio, Waxman, Adam J., Chong, Emeline R., Patel, Vrutti, Pajarillo, Raymone, Kulikovskaya, Irina, Lieberman, David B., Cohen, Adam D., Levine, Bruce L., Stadtmauer, Edward A., Frey, Noelle V., Vogl, Dan T., Hexner, Elizabeth O., Barta, Stefan K., Porter, David L., Garfall, Alfred L., Schuster, Stephen J., June, Carl H., Ruella, Marco

“…We report a T cell lymphoma (TCL) occurring 3 months after anti-CD19 chimeric antigen receptor (CAR) T cell immunotherapy for non-Hodgkin B cell lymphoma. The…”
Get full text

Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine by Irwin, David J., Cairns, Nigel J., Grossman, Murray, McMillan, Corey T., Lee, Edward B., Van Deerlin, Vivianna M., Lee, Virginia M.-Y., Trojanowski, John Q.

“…Frontotemporal lobar degeneration (FTLD) comprises two main classes of neurodegenerative diseases characterized by neuronal/glial proteinaceous inclusions…”
Get full text