Search Results - "Deen, Peter M.T."

AQP2 Abundance is Regulated by the E3-Ligase CHIP Via HSP70 by Centrone, Mariangela, Ranieri, Marianna, Di Mise, Annarita Di, Berlingerio, Sante Princiero, Russo, Annamaria, Deen, Peter M.T., Staub, Olivier, Valenti, Giovanna, Tamma, Grazia

“…Background/Aims: AQP2 expression is mainly controlled by vasopressin-dependent changes in protein abundance which is in turn regulated by AQP2 ubiquitylation…”
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Intellectual disability and bleeding diathesis due to deficient CMP–sialic acid transport by Mohamed, Miski, Ashikov, Angel, Guillard, Mailys, Robben, Joris H, Schmidt, Samuel, van den Heuvel, B, de Brouwer, Arjan P.M, Gerardy-Schahn, Rita, Deen, Peter M.T, Wevers, Ron A, Lefeber, Dirk J, Morava, Eva

“…OBJECTIVE:To identify the underlying genetic defect in a patient with intellectual disability, seizures, ataxia, macrothrombocytopenia, renal and cardiac…”
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An impaired routing of wild-type aquaporin-2 after tetramerization with an aquaporin-2 mutant explains dominant nephrogenic diabetes insipidus by Kamsteeg, Erik-Jan, Wormhoudt, Thera A.M., Rijss, Johan P.L., van Os, Carel H., Deen, Peter M.T.

“…Autosomal recessive and dominant nephrogenic diabetes insipidus (NDI), a disease in which the kidney is unable to concentrate urine in response to vasopressin,…”
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SUCNR1-mediated chemotaxis of macrophages aggravates obesity-induced inflammation and diabetes by van Diepen, Janna A., Robben, Joris H., Hooiveld, Guido J., Carmone, Claudia, Alsady, Mohammad, Boutens, Lily, Bekkenkamp-Grovenstein, Melissa, Hijmans, Anneke, Engelke, Udo F. H., Wevers, Ron A., Netea, Mihai G., Tack, Cees J., Stienstra, Rinke, Deen, Peter M. T.

“…Aims/hypothesis Obesity induces macrophages to drive inflammation in adipose tissue, a crucial step towards the development of type 2 diabetes. The…”
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Congenital nephrogenic diabetes insipidus: the current state of affairs by Wesche, Daniel, Deen, Peter M. T., Knoers, Nine V. A. M.

“…The anti-diuretic hormone arginine vasopressin (AVP) is released from the pituitary upon hypovolemia or hypernatremia, and regulates water reabsorption in the…”
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Thiazide-induced hyponatraemia is associated with increased water intake and impaired urea-mediated water excretion at low plasma antidiuretic hormone and urine aquaporin-2 by Frenkel, Nanne J, Vogt, Liffert, De Rooij, Sophia E, Trimpert, Christiane, Levi, Marcel M, Deen, Peter M.T, van den Born, Bert-Jan H

“…BACKGROUND:Hyponatraemia is a common, potentially life-threatening, complication of thiazide diuretics. The mechanism of thiazide-induced hyponatraemia is…”
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Amiloride blocks lithium entry through the sodium channel thereby attenuating the resultant nephrogenic diabetes insipidus by Kortenoeven, Marleen L.A., Li, Yuedan, Shaw, Stephen, Gaeggeler, Hans-Peter, Rossier, Bernard C., Wetzels, Jack F.M., Deen, Peter M.T.

“…Lithium therapy frequently induces nephrogenic diabetes insipidus; amiloride appears to prevent its occurrence in some clinical cases. Amiloride blocks the…”
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SLC29A3 gene is mutated in pigmented hypertrichosis with insulin-dependent diabetes mellitus syndrome and interacts with the insulin signaling pathway by Cliffe, Simon T., Kramer, Jamie M., Hussain, Khalid, Robben, Joris H., de Jong, Eiko K., de Brouwer, Arjan P., Nibbeling, Esther, Kamsteeg, Erik-Jan, Wong, Melanie, Prendiville, Julie, James, Chela, Padidela, Raja, Becknell, Charlie, van Bokhoven, Hans, Deen, Peter M.T., Hennekam, Raoul C.M., Lindeman, Robert, Schenck, Annette, Roscioli, Tony, Buckley, Michael F.

“…Pigmented hypertrichotic dermatosis with insulin-dependent diabetes (PHID) syndrome is a recently described autosomal recessive disorder associated with…”
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Intracellular activation of vasopressin V2 receptor mutants in nephrogenic diabetes insipidus by nonpeptide agonists by Robben, Joris H, Kortenoeven, Marleen L.A, Sze, Mozes, Yae, Chris, Milligan, Graeme, Oorschot, Viola M, Klumperman, Judith, Knoers, Nine V.A.M, Deen, Peter M.T

“…Binding of the peptide hormone vasopressin to its type-2 receptor (V2R) in kidney triggers a cAMP-mediated translocation of Aquaporin-2 water channels to the…”
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The Role of Putative Phosphorylation Sites in the Targeting and Shuttling of the Aquaporin-2 Water Channel by van Balkom, Bas W M, Savelkoul, Paul J M, Markovich, Daniel, Hofman, Erik, Nielsen, Soren, van der Sluijs, Peter, Deen, Peter M T

“…In renal collecting ducts, a vasopressin-induced cAMP increase results in the phosphorylation of aquaporin-2 (AQP2) water channels at Ser-256 and its…”
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Marine Fish Egg Hydration Is Aquaporin-Mediated by Fabra, Mercedes, Raldúa, Demetrio, Power, Deborah M, Deen, Peter M. T, Cerdà, Joan

“…The positive buoyancy of marine fish eggs in sea water, allowed by hydration of the oocyte, is critical for their survival and dispersion in the ocean. We…”
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Yolk proteolysis and aquaporin-1o play essential roles to regulate fish oocyte hydration during meiosis resumption by Fabra, Mercedes, Raldúa, Demetrio, Bozzo, María G., Deen, Peter M.T., Lubzens, Esther, Cerdà, Joan

“…In marine fish, meiosis resumption is associated with a remarkable hydration of the oocyte, which contributes to the survival and dispersal of eggs and early…”
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Aquaporin 2 Mutations in Nephrogenic Diabetes Insipidus by Loonen, Anne J.M., MSc, Knoers, Nine V.A.M., MD, PhD, van Os, Carel H., PhD, Deen, Peter M.T., PhD

“…Summary Water reabsorption in the renal collecting duct is regulated by the antidiuretic hormone vasopressin (AVP). When the vasopressin V2 receptor, present…”
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Impact of acute versus repetitive moderate intensity endurance exercise on kidney injury markers by Bongers, Coen C. W. G., Alsady, Mohammad, Nijenhuis, Tom, Hartman, Yvonne A. W., Eijsvogels, Thijs M. H., Deen, Peter M. T., Hopman, Maria T. E.

“…Exercise may lead to kidney injury through several mechanisms. Urinary Kidney Injury Molecule‐1 (uKIM1) and Neutrophil Gelatinase‐Associated Lipocalin (uNGAL)…”
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MAL decreases the internalization of the aquaporin-2 water channel by Kamsteeg, Erik-Jan, Duffield, Amy S, Konings, Irene B.M, Spencer, Joanna, Pagel, Philipp, Deen, Peter M.T, Caplan, Michael J

“…Body water homeostasis depends critically on the hormonally regulated trafficking of aquaporin-2 (AQP2) water channels in renal collecting duct epithelial…”
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Hypotonicity-induced Reduction of Aquaporin-2 Transcription in mpkCCD Cells Is Independent of the Tonicity Responsive Element, Vasopressin, and cAMP by Kortenoeven, Marleen L.A., van den Brand, Michiel, Wetzels, Jack F.M., Deen, Peter M.T.

“…The syndrome of inappropriate antidiuretic hormone secretion is characterized by excessive water uptake and hyponatremia. The extent of hyponatremia, however,…”
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Lack of arginine vasopressin-induced phosphorylation of aquaporin-2 mutant AQP2-R254L explains dominant nephrogenic diabetes insipidus by DE MATTIA, Fabrizio, SAVELKOUL, Paul J. M, KAMSTEEG, Erik-Jan, KONINGS, Irene B. M, VAN DER SLUIJS, Peter, MALLMANN, Rudolf, OKSCHE, Alexander, DEEN, Peter M. T

“…Water homeostasis in humans is regulated by vasopressin, which induces the translocation of homotetrameric aquaporin-2 (AQP2) water channels from intracellular…”
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Reversed Polarized Delivery of an Aquaporin-2 Mutant Causes Dominant Nephrogenic Diabetes Insipidus by Kamsteeg, Erik-Jan, Bichet, Daniel G., Irene B. M. Konings, Nivet, Hubert, Lonergan, Michelle, Arthus, Marie-Françoise, van Os, Carel H., Peter M. T. Deen

“…Vasopressin regulates body water conservation by redistributing aquaporin-2 (AQP2) water channels from intracellular vesicles to the apical surface of renal…”
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Repulsion between Lys258 and upstream arginines explains the missorting of the AQP2 mutant p.Glu258Lys in nephrogenic diabetes insipidus by Kamsteeg, Erik-Jan, Stoffels, Monique, Tamma, Grazia, Konings, Irene B.M, Deen, Peter M.T

“…Regulation of body water homeostasis occurs by the vasopressin-dependent sorting of aquaporin-2 (AQP2) water channels to and from the apical membrane of renal…”
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Pharmacological chaperones in nephrogenic diabetes insipidus: possibilities for clinical application by Robben, Joris H, Deen, Peter M T

“…The antidiuretic hormone arginine-vasopressin regulates water homeostasis in the human body by binding to its vasopressin type 2 receptor (V2R). Mutations in…”
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