Search Results - "Deeks, G Steven"

HIV infection, inflammation, immunosenescence, and aging by Deeks, Steven G

“…Although antiretroviral therapy for HIV infection prevents AIDS-related complications and prolongs life, it does not fully restore health. Long-term treated…”
Get full text

Systemic Effects of Inflammation on Health during Chronic HIV Infection by Deeks, Steven G., Tracy, Russell, Douek, Daniel C.

“…Combination antiretroviral therapy for HIV infection improves immune function and eliminates the risk of AIDS-related complications but does not restore full…”
Get full text

The end of AIDS: HIV infection as a chronic disease by Deeks, Steven G, Prof, Lewin, Sharon R, Prof, Havlir, Diane V, Prof

“…Summary The success of antiretroviral therapy has led some people to now ask whether the end of AIDS is possible. For patients who are motivated to take…”
Get full text

Early clues regarding the pathogenesis of long-COVID by Peluso, Michael J., Deeks, Steven G.

“…Intense investigation into the predictors and determinants of post-acute sequelae of SARS-CoV-2 infection (PASC), including ‘long COVID’, is underway. Recent…”
Get full text

The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies by Cohn, Lillian B, Chomont, Nicolas, Deeks, Steven G

“…Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the integrated HIV genome persists indefinitely within CD4 T cells and…”
Get full text

Immunologic strategies for HIV-1 remission and eradication by Barouch, Dan H., Deeks, Steven G.

“…Antiretroviral therapy (ART) is able to suppress HIV-1 replication indefinitely in individuals who have access to these medications, are able to tolerate these…”
Get full text

HIV control: Is getting there the same as staying there? by Goulder, Philip, Deeks, Steven G

“…In this brief review and perspective, we address the question of whether the immune responses that bring about immune control of acute HIV infection are the…”
Get full text

Persistent HIV-1 replication during antiretroviral therapy by Martinez-Picado, Javier, Deeks, Steven G

“…PURPOSE OF REVIEWThe present review will highlight some of the recent findings regarding the capacity of HIV-1 to replicate during antiretroviral therapy…”
Get full text

Antiretroviral therapy and management of HIV infection by Volberding, Paul A, Prof, Deeks, Steven G, Prof

“…Summary Antiretroviral therapy of HIV infection has changed a uniformly fatal into a potentially chronic disease. There are now 17 drugs in common use for HIV…”
Get full text

HIV reservoirs: what, where and how to target them by Churchill, Melissa J., Deeks, Steven G., Margolis, David M., Siliciano, Robert F., Swanstrom, Ronald

“…Viral reservoirs pose a major challenge in the efforts towards curing HIV. Here, Churchill, Deeks, Margolis, Siliciano and Swanstrom discuss the cells and…”
Get full text

Immune activation and HIV persistence: implications for curative approaches to HIV infection by Klatt, Nichole R., Chomont, Nicolas, Douek, Daniel C., Deeks, Steven G.

“…Summary Despite complete or near‐complete suppression of human immunodeficiency virus (HIV) replication with combination antiretroviral therapy, both HIV and…”
Get full text

CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART by Fromentin, Rémi, Bakeman, Wendy, Lawani, Mariam B, Khoury, Gabriela, Hartogensis, Wendy, DaFonseca, Sandrina, Killian, Marisela, Epling, Lorrie, Hoh, Rebecca, Sinclair, Elizabeth, Hecht, Frederick M, Bacchetti, Peter, Deeks, Steven G, Lewin, Sharon R, Sékaly, Rafick-Pierre, Chomont, Nicolas

“…HIV persists in a small pool of latently infected cells despite antiretroviral therapy (ART). Identifying cellular markers expressed at the surface of these…”
Get full text

PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals by Fromentin, Rémi, DaFonseca, Sandrina, Costiniuk, Cecilia T., El-Far, Mohamed, Procopio, Francesco Andrea, Hecht, Frederick M., Hoh, Rebecca, Deeks, Steven G., Hazuda, Daria J., Lewin, Sharon R., Routy, Jean-Pierre, Sékaly, Rafick-Pierre, Chomont, Nicolas

“…HIV persists in latently infected CD4 + T cells during antiretroviral therapy (ART). Immune checkpoint molecules, including PD-1, are preferentially expressed…”
Get full text

Long-term SARS-CoV-2-specific immune and inflammatory responses in individuals recovering from COVID-19 with and without post-acute symptoms by Peluso, Michael J., Deitchman, Amelia N., Torres, Leonel, Iyer, Nikita S., Munter, Sadie E., Nixon, Christopher C., Donatelli, Joanna, Thanh, Cassandra, Takahashi, Saki, Hakim, Jill, Turcios, Keirstinne, Janson, Owen, Hoh, Rebecca, Tai, Viva, Hernandez, Yanel, Fehrman, Emily A., Spinelli, Matthew A., Gandhi, Monica, Trinh, Lan, Wrin, Terri, Petropoulos, Christos J., Aweeka, Francesca T., Rodriguez-Barraquer, Isabel, Kelly, J. Daniel, Martin, Jeffrey N., Deeks, Steven G., Greenhouse, Bryan, Rutishauser, Rachel L., Henrich, Timothy J.

“…We describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell responses, soluble markers of inflammation, and antibody levels and…”
Get full text

Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs by Katlama, Christine, Prof, Deeks, Steven G, MD, Autran, Brigitte, Prof, Martinez-Picado, Javier, Prof, van Lunzen, Jan, Prof, Rouzioux, Christine, Prof, Miller, Michael, PhD, Vella, Stefano, MD, Schmitz, Joern E, Prof, Ahlers, Jeffrey, PhD, Richman, Douglas D, MD, Sekaly, Rafick P, Dr

“…Summary Antiretroviral therapy for HIV infection needs lifelong access and strict adherence to regimens that are both expensive and associated with toxic…”
Get full text

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations by Deng, Kai, Pertea, Mihaela, Rongvaux, Anthony, Wang, Leyao, Durand, Christine M., Ghiaur, Gabriel, Lai, Jun, McHugh, Holly L., Hao, Haiping, Zhang, Hao, Margolick, Joseph B., Gurer, Cagan, Murphy, Andrew J., Valenzuela, David M., Yancopoulos, George D., Deeks, Steven G., Strowig, Till, Kumar, Priti, Siliciano, Janet D., Salzberg, Steven L., Flavell, Richard A., Shan, Liang, Siliciano, Robert F.

“…Despite receiving antiretroviral therapy, most patients with HIV still have latent reservoirs of the virus; here, these reservoirs are shown to be dominated by…”
Get full text

Relevance of Interleukin-6 and D-Dimer for Serious Non-AIDS Morbidity and Death among HIV-Positive Adults on Suppressive Antiretroviral Therapy by Grund, Birgit, Baker, Jason V, Deeks, Steven G, Wolfson, Julian, Wentworth, Deborah, Cozzi-Lepri, Alessandro, Cohen, Calvin J, Phillips, Andrew, Lundgren, Jens D, Neaton, James D

“…Despite effective antiretroviral treatment (ART), HIV-positive individuals are at increased risk of serious non-AIDS conditions (cardiovascular, liver and…”
Get full text

Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection by Sandler, Netanya G., Wand, Handan, Roque, Annelys, Law, Matthew, Nason, Martha C., Nixon, Daniel E., Pedersen, Court, Ruxrungtham, Kiat, Lewin, Sharon R., Emery, Sean, Neaton, James D., Brenchley, Jason M., Deeks, Steven G., Sereti, Irini, Douek, Daniel C.

“…Background. Chronic human immunodeficiency virus (HIV) infection is associated with intestinal permeability and microbial translocation that contributes to…”
Get full text

Viral protein Nef is detected in plasma of half of HIV-infected adults with undetectable plasma HIV RNA by Ferdin, Jana, Goričar, Katja, Dolžan, Vita, Plemenitaš, Ana, Martin, Jeffrey N, Peterlin, Boris M, Deeks, Steven G, Lenassi, Metka

“…To address the role of translationally active HIV reservoir in chronic inflammation and non-AIDS related disorders, we first need a simple and accurate assay…”
Get full text

Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated Participants by Hiener, Bonnie, Horsburgh, Bethany A., Eden, John-Sebastian, Barton, Kirston, Schlub, Timothy E., Lee, Eunok, von Stockenstrom, Susanne, Odevall, Lina, Milush, Jeffrey M., Liegler, Teri, Sinclair, Elizabeth, Hoh, Rebecca, Boritz, Eli A., Douek, Daniel, Fromentin, Rémi, Chomont, Nicolas, Deeks, Steven G., Hecht, Frederick M., Palmer, Sarah

“…Latent replication-competent HIV-1 persists in individuals on long-term antiretroviral therapy (ART). We developed the Full-Length Individual Proviral…”
Get full text