Search Results - "Dee Carey, K."

Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates by Brunetti-Pierri, Nicola, Palmer, Donna J, Beaudet, Arthur L, Carey, K Dee, Finegold, Milton, Ng, Philip

“…Systemic intravascular delivery of adenoviral (Ad) vectors for liver-directed gene therapy has been widely employed because of its simplicity, noninvasiveness,…”
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The Aging Baboon: Comparative Demography in a Non-Human Primate by Bronikowski, Anne M., Alberts, Susan C., Altmann, Jeanne, Packer, Craig, Carey, K. Dee, Tatar, Marc

“…Why do closely related primate genera vary in longevity, and what does this teach us about human aging? Life tables of female baboons (Papio hamadryas) in two…”
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Administration of Helper-Dependent Adenoviral Vectors and Sequential Delivery of Different Vector Serotype for Long-Term Liver-Directed Gene Transfer in Baboons by Morral, Núria, O'Neal, Wanda, Rice, Karen, Leland, Michele, Kaplan, Johanne, Piedra, Pedro A., Zhou, Heshan, Parks, Robin J., Velji, Rizwan, Aguilar-Córdova, Estuardo, Wadsworth, Samuel, Graham, Frank L., Kochanek, Stefan, Carey, K. Dee, Beaudet, Arthur L.

“…The efficiency of first-generation adenoviral vectors as gene delivery tools is often limited by the short duration of transgene expression, which can be…”
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Improved hepatic transduction, reduced systemic vector dissemination, and long-term transgene expression by delivering helper-dependent adenoviral vectors into the surgically isolated liver of nonhuman primates by Brunetti-Pierri, Nicola, Ng, Thomas, Iannitti, David A, Palmer, Donna J, Beaudet, Arthur L, Finegold, Milton J, Carey, K Dee, Cioffi, William G, Ng, Philip

“…Helper-dependent adenoviral vectors (HDAds) are attractive vectors for liver-directed gene therapy because they can mediate sustained, high-level transgene…”
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baboon as a nonhuman primate model for the study of the genetics of obesity by Comuzzie, A.G, Cole, S.A, Martin, L, Carey, K.D, Mahaney, M.C, Blangero, J, VandeBerg, J.L

“…Objective: At present, rodents represent the most common animal model for research in obesity and its comorbidities (e.g., type 2 diabetes and coronary heart…”
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Lifespan in captive baboons is heritable by Martin, Lisa J, Mahaney, Michael C, Bronikowski, Anne M, Dee Carey, K, Dyke, Bennett, Comuzzie, Anthony G

“…The effects of aging are evident in multiple organ systems, tissues, cell types, and molecules; all complex phenotypes affected by multiple shared and unique…”
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Contrast Sonography, Video Densitometry and Intervillous Blood Flow: A Pilot Project by Barth, W.H., McCurnin, D.C., Dee Carey, K., Hankins, G.D.V.

“…To examine the feasibility of constructing time-intensity (TI) curves from the intervillous space with an intravascular ultrasound contrast agent and computer…”
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Arterial wall-determined risk factors to vascular diseases: a nonhuman primate model by Wang, Xing Li, Wang, Jian, Shi, Qiang, Carey, K Dee, VandeBerg, John L

“…Many decades of research have led to considerable in-depth understanding of circulating factors that may lead to coronary atherosclerosis. However, not every…”
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Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons by Morral, Núria, O'Neal, Wanda K, Rice, Karen, Leland, M Michelle, Piedra, Pedro A, Aguilar-Córdova, Estuardo, Carey, K Dee, Beaudet, Arthur L, Langston, Claire

“…The effects of intravenous administration of a first-generation adenoviral vector expressing beta-galactosidase were compared in two baboons receiving a high…”
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Renal Histopathology of a Baboon Model with Type 2 Diabetes by Rincon-Choles, Hernan, Abboud, Hanna E., Lee, Shuko, Shade, Robert E., Rice, Karen S., Carey, K. Dee, Comuzzie, Anthony G., Barnes, Jeffrey L.

“…Naturally occurring type 2 diabetes has been found in a colony of baboons. Ongoing characterization of the baboon colony maintained at the Southwest National…”
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Evaluation of the impact of concurrent gonadotropin-releasing hormone (GnRH) antagonist administration on GnRH agonist-induced gonadotrope desensitization by Illions, E H, Scott, R T, Carey, K D, Navot, D

“…To evaluate the impact of chronic GnRH antagonist therapy on the extent of GnRH agonist-induced gonadotrope desensitization. Prospective and controlled…”
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Effects of estrogen and progesterone on plasma lipoproteins and experimental atherosclerosis in the baboon (papio sp.) by KUSHWAHA, R. S, LEWIS, D. S, DEE CAREY, K, MCGILL, H. C

“…We determined the effect of estrogen and progesterone on plasma cholesterol and lipoprotein cholesterol concentrations and on arterial lesions in 24…”
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A Quantitative Trait Locus Influencing Activin-to-Estrogen Ratio in Pedigreed Baboons Maps to a Region Homologous to Human Chromosome 19 by MARTIN, LISA J., BLANGERO, JOHN, ROGERS, JEFFREY, MAHANEY, MICHAEL C., HIXSON, JAMES E., CAREY, K. DEE, COMUZZIE, ANTHONY G.

“…Activin is a multifunctional hormone playing a major role in the regulation of reproduction and growth and development. We performed a genomewide scan using…”
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Effect of Dietary Cholesterol and Fat on the Expression of Hepatic Sterol 27-Hydroxylase and Other Hepatic Cholesterol-Responsive Genes in Baboons (Papio Species) by Kushwaha, Rampratap S, Guntupalli, Bharathi, Rice, Karen S, Carey, K. Dee, McGill, Jr

“…Our studies of baboons with low and high responses to dietary cholesterol and fat suggest that low-responding baboons increase the activity of hepatic sterol…”
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The pathogenesis of experimental toxic shock syndrome: the role of interleukin-2 in the induction of hypotension and release of cytokines by Tokman, M G, Carey, K D, Quimby, F W

“…Toxic shock syndrome (TSS) is a multisystem disorder characterized by fever, hypotension, and involvement of three other organ systems. The etiologic agent is…”
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Gonadotropin-releasing hormone antagonist administration enhances gonadotrope responsiveness at doses inadequate to suppress immunoassayable gonadotropin levels by Scott, Jr, R T, Illions, E H, Carey, K D, Navot, D

“…Chronic GnRH antagonist therapy produces enhanced gonadotrope responsiveness to supraphysiologic stimuli despite the lack of any measurable suppression of…”
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Metabolic regulation of apoproteins of high-density lipoproteins by estrogen and progesterone in the baboon (Papio sp) by Kushwaha, R S, Foster, D M, Murthy, V N, Carey, K D, Bernard, M G

“…To determine the metabolic regulation of the apoproteins of high-density lipoproteins (HDL) by estrogen and progesterone, 12 ovariectomized and hysterectomized…”
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Hepsulfam distribution in blood, plasma and cerebrospinal fluid of baboons by MARSHALL, M. V, DEE CAREY, K, VON HOFF, D. D, KUHN, J. G

“…The alkylating agent Hepsulfam (Sulfamic acid 1,7-heptanediyl ester, NSC 329680) was developed as a more hydrophilic analog of busulfan. The objective of this…”
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Pharmacokinetics of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in laboratory animals by Adams, J D, Lavoie, E J, O'Mara-Adams, K J, Hoffmann, D, Carey, K D, Marshall, M V

“…The pharmacokinetics of N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in the Syrian golden hamster, the CD-1 mouse, and…”
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Cyclic Oscillations in Melanin Composition within Hairs of Baboons by Ito, Shosuke, Wakamatsu, Kazumasa, Matsunaga, Naoko, Hearing, Vincent J., Carey, K. Dee, Anderson, Sydney, Dooley, Thomas P.

“…The wild‐type agouti‐banding pattern for hair is well characterized in lower mammals such as mice. The switch between eumelanin and pheomelanin in bands in the…”
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