Search Results - "Dedousis, Nikolaos"

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance by WAN HUANG, METLAKUNTA, Anantha, DEDOUSIS, Nikolaos, PILI ZHANG, SIPULA, Ian, DUBE, John J, SCOTT, Donald K, O'DOHERTY, Robert M

“…Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance Wan Huang 1 , Anantha Metlakunta 1 ,…”
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A single-day mouse mesenteric lymph surgery in mice: an updated approach to study dietary lipid absorption, chylomicron secretion, and lymphocyte dynamics by Dedousis, Nikolaos, Teng, Lihong, Kanshana, Jitendra S., Kohan, Alison B.

“…The intestine plays a crucial role in regulating whole-body lipid metabolism through its unique function of absorbing dietary fat. In the small intestine,…”
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The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion by Dedousis, Nikolaos L, Teng, Lihong, Kohan, Alison B

“…Intestinal lipoproteins, especially triglyceride-rich chylomicrons, are a major driver of metabolism, inflammation, and cardiovascular diseases. However,…”
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Impaired intestinal free fatty acid transport followed by chylomicron malformation, not pancreatic insufficiency, cause metabolic defects in cystic fibrosis by Teng, Lihong, Dedousis, Nikolaos, Adeshirlarijaney, Aneseh, Kanshana, Jitendra S., Liu, Min, Hodges, Craig A., Kohan, Alison B.

“…Intestinal disease is one of the earliest manifestations of cystic fibrosis (CF) in children and is closely tied to deficits in growth and nutrition, both of…”
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Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c+ Cells in Adipose Tissue and Liver by STEFANOVIC-RACIC, Maja, XIAO YANG, THOMSON, Angus W, O'DOHERTY, Robert M, TURNER, Michael S, MANTELL, Benjamin S, STOLZ, Donna B, SUMPTER, Tina L, SIPULA, Ian J, DEDOUSIS, Nikolaos, SCOTT, Donald K, MOREL, Penelope A

“…Obesity-associated increases in adipose tissue (AT) CD11c(+) cells suggest that dendritic cells (DC), which are involved in the tissue recruitment and…”
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Kupffer cells facilitate the acute effects of leptin on hepatic lipid metabolism by Metlakunta, Anantha, Huang, Wan, Stefanovic-Racic, Maja, Dedousis, Nikolaos, Sipula, Ian, O'Doherty, Robert M

“…Leptin has potent effects on lipid metabolism in a number of peripheral tissues. In liver, an acute leptin infusion (~120 min) stimulates hepatic fatty acid…”
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Adropin reduces blood glucose levels in mice by limiting hepatic glucose production by Thapa, Dharendra, Xie, Bingxian, Manning, Janet R., Zhang, Manling, Stoner, Michael W., Huckestein, Brydie R., Edmunds, Lia R., Zhang, Xueyang, Dedousis, Nikolaos L., O'Doherty, Robert M., Jurczak, Michael J., Scott, Iain

“…Adropin is a liver‐ and brain‐secreted peptide hormone with striking effects on fuel metabolism regulation in a number of tissues. Previous studies…”
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Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities by Harmon, Daniel B, Mandler, W Kyle, Sipula, Ian J, Dedousis, Nikolaos, Lewis, Sara E, Eckels, Jeremy T, Du, Jianhai, Wang, Yekai, Huckestein, Brydie R, Pagano, Patrick J, Cifuentes-Pagano, Eugenia, Homanics, Gregg E, Van't Erve, Thomas J, Stefanovic-Racic, Maja, Jurczak, Michael J, O'Doherty, Robert M, Kelley, Eric E

“…Systemic hyperuricemia (HyUA) in obesity/type 2 diabetes facilitated by elevated activity of xanthine oxidoreductase (XOR), which is the sole source of uric…”
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Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance by Belmonte, Frances R, Dedousis, Nikolaos, Sipula, Ian, Desai, Nikita A, Singhi, Aatur D, Chu, Yanxia, Zhang, Yingze, Bannwarth, Sylvie, Paquis-Flucklinger, Véronique, Harrington, Lea, Shiva, Sruti, Jurczak, Michael J, O'Doherty, Robert M, Kaufman, Brett A

“…Petite Integration Factor 1 (PIF1) is a multifunctional helicase present in nuclei and mitochondria. PIF1 knock out (KO) mice exhibit accelerated weight gain…”
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Hepatocyte-derived GDF15 suppresses feeding and improves insulin sensitivity in obese mice by Xie, Bingxian, Murali, Anjana, Vandevender, Amber M., Chen, Jeffrey, Silva, Agustin Gil, Bello, Fiona M., Chuan, Byron, Bahudhanapati, Harinath, Sipula, Ian, Dedousis, Nikolaos, Shah, Faraaz A., O’Donnell, Christopher P., Alder, Jonathan K., Jurczak, Michael J.

“…Growth differentiation factor 15 (GDF15) is a stress-induced secreted protein whose circulating levels are increased in the context of obesity. Recombinant…”
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Similar degrees of obesity induced by diet or aging cause strikingly different immunologic and metabolic outcomes by Krishna, Kanthi B., Stefanovic‐Racic, Maja, Dedousis, Nikolaos, Sipula, Ian, O'Doherty, Robert M.

“…In obesity, adipose tissue (AT) and liver are infiltrated with Th‐1 polarized immune cells, which are proposed to play an important role in the pathogenesis of…”
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2039-LB: Insulin Sensitivity Is Impaired Independent of Changes in Body Weight in Liver-Specific GDF15 Knockout Mice by Kastroll, Jake, Jurczak, Michael J, Alder, Jonathan, Vandevender, Amber, Dedousis, Nikolaos, Sipula, Ian J

“…Introduction & Objective: Growth differentiation factor 15 (GDF15), a stress-induced protein, constrains body weight gain in models of obesity by reducing…”
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3-OR: Hepatocyte Gdf15 Is Sufficient for Increased Plasma GDF15 Levels and Body Weight Constraint during High-Fat–Diet Feeding and Restores Insulin Sensitivity in a Liver-Specific Manner by XIE, BINGXIAN, MURALI, ANJANA, VANDEVENDER, AMBER, GIL SILVA, AGUSTIN A., BELLO, FIONA, SIPULA, IAN J., DEDOUSIS, NIKOLAOS, ALDER, JONATHAN, JURCZAK, MICHAEL J.

“…Growth and differentiation factor 15 (GDF15) is a stress-induced secreted protein whose plasma levels are increased in obese patients. Recombinant GDF15…”
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Cardiolipin deficiency elevates susceptibility to a lipotoxic hypertrophic cardiomyopathy by Cole, Laura K., Mejia, Edgard M., Sparagna, Genevieve C., Vandel, Marilyne, Xiang, Bo, Han, Xianlin, Dedousis, Nikolaos, Kaufman, Brett A., Dolinsky, Vernon W., Hatch, Grant M.

“…Cardiolipin (CL) is a unique tetra-acyl phospholipid localized to the inner mitochondrial membrane and essential for normal respiratory function. It has been…”
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Adipose tissue-derived free fatty acids initiate myeloid cell accumulation in mouse liver in states of lipid oversupply by Harmon, Daniel B, Wu, Chao, Dedousis, Nikolaos, Sipula, Ian J, Stefanovic-Racic, Maja, Schoiswohl, Gabriele, O'Donnell, Christopher P, Alonso, Laura C, Kershaw, Erin E, Kelley, Eric E, O'Doherty, Robert M

“…Accumulation of myeloid cells in the liver, notably dendritic cells (DCs) and monocytes/macrophages (MCs), is a major component of the metainflammation of…”
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Petite Integration Factor 1 by Belmonte, Frances R, Dedousis, Nikolaos, Sipula, Ian, Desai, Nikita A, Singhi, Aatur D, Chu, Yanxia, Zhang, Yingze, Bannwarth, Sylvie, Paquis-Flucklinger, Véronique, Harrington, Lea, Shiva, Sruti, Jurczak, Michael J, O'Doherty, Robert M, Kaufman, Brett A

“…Petite Integration Factor 1 (PIF1) is a multifunctional helicase present in nuclei and mitochondria. PIF1 knock out (KO) mice exhibit accelerated weight gain…”
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Elevated metabolic rate and skeletal muscle oxidative metabolism contribute to the reduced susceptibility of NF‐κB p50 null mice to obesity by Bhatt, Bankim A., Dedousis, Nikolaos, Sipula, Ian J., O'Doherty, Robert M.

“…Mice with a deletion of the p50 subunit of the proinflammatory nuclear factor kappa B pathway (NF‐κB p50) have reduced weight compared to wild‐type control…”
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Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c^sup +^ Cells in Adipose Tissue and Liver by Stefanovic-Racic, Maja, Yang, Xiao, Turner, Michael S, Mantell, Benjamin S, Stolz, Donna B, Sumpter, Tina L, Sipula, Ian J, Dedousis, Nikolaos, Scott, Donald K, Morel, Penelope A, Thomson, Angus W, O'Doherty, Robert M

“…Obesity-associated increases in adipose tissue (AT) CD11c(+) cells suggest that dendritic cells (DC), which are involved in the tissue recruitment and…”
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Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in [CD11c.sup.+] cells in adipose tissue and liver by Stefanovic-Racic, Maja, Yang, Xiao, Turner, Michael S, Mantell, Benjamin S, Stolz, Donna B, Sumpter, Tina L, Sipula, Ian J, Dedousis, Nikolaos, Scott, Donald K, Morel, Penelope A, Thomson, Angus W, O'Doherty, Robert M

“…Obesity-associated increases in adipose tissue (AT) [CD11c.sup.+] cells suggest that dendritic cells (DC), which are involved in the tissue recruitment and…”
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