Search Results - "Dedloff, Margaret"
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Cytochrome oxidase requirements in Bordetella reveal insights into evolution towards life in the mammalian respiratory tract
Published in PLoS pathogens (08-07-2024)“…Little is known about oxygen utilization during infection by bacterial respiratory pathogens. The classical Bordetella species, including B. pertussis, the…”
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Antiviral and Immunomodulatory Effects of Interferon Lambda at the Maternal-Fetal Interface
Published in Annual review of virology (26-09-2024)“…Interferon lambda (IFN-λ, type III IFN, IL-28/29) is a family of antiviral cytokines that are especially important at barrier sites, including the…”
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Use of Biopolymers in Mucosally-Administered Vaccinations for Respiratory Disease
Published in Materials (31-07-2019)“…Communicable respiratory infections are the cause of a significant number of infectious diseases. The introduction of vaccinations has greatly improved this…”
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A novel group of secretory cells regulates development of the immature intestinal stem cell niche through repression of the main signaling pathways driving proliferation
Published in Developmental biology (01-12-2019)“…The intestinal epithelium has constant turnover throughout the life of the organ, with apoptosis of cells at the tips of folds or villi releasing cells into…”
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Novel Therapeutic Strategies Applied to Pseudomonas aeruginosa Infections in Cystic Fibrosis
Published in Materials (07-12-2019)“…Cystic fibrosis (CF) is one of the most prevalent genetic diseases and a total of 1700 different genetic mutations can cause this condition. Patients that…”
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DegP Initiates Regulated Processing of Filamentous Hemagglutinin in Bordetella bronchiseptica
Published in mBio (29-06-2021)“…Filamentous hemagglutinin (FhaB) is a critical virulence factor for both Bordetella pertussis, the causal agent of whooping cough, and the closely related…”
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Computational Health Engineering Applied to Model Infectious Diseases and Antimicrobial Resistance Spread
Published in Applied sciences (01-06-2019)“…Infectious diseases are the primary cause of mortality worldwide. The dangers of infectious disease are compounded with antimicrobial resistance, which remains…”
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Blood or Serum Exposure Induce Global Transcriptional Changes, Altered Antigenic Profile, and Increased Cytotoxicity by Classical Bordetellae
Published in Frontiers in microbiology (07-09-2018)“…The classical bordetellae sense and respond to a variety of environments outside and within their mammalian hosts. By causing inflammation and tissue damage,…”
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