Search Results - "Dedes, Konstantin"

ARID1A mutations and PI3K/AKT pathway alterations in endometriosis and endometriosis-associated ovarian carcinomas by Samartzis, Eleftherios P, Noske, Aurelia, Dedes, Konstantin J, Fink, Daniel, Imesch, Patrick

“…Endometriosis is a common gynecological disease affecting 6%-10% of women of reproductive age and is characterized by the presence of endometrial-like tissue…”
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Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial by Vaidya, Jayant S, Bulsara, Max, Baum, Michael, Wenz, Frederik, Massarut, Samuele, Pigorsch, Steffi, Alvarado, Michael, Douek, Michael, Saunders, Christobel, Flyger, Henrik L, Eiermann, Wolfgang, Brew-Graves, Chris, Williams, Norman R, Potyka, Ingrid, Roberts, Nicholas, Bernstein, Marcelle, Brown, Douglas, Sperk, Elena, Laws, Siobhan, Sütterlin, Marc, Corica, Tammy, Lundgren, Steinar, Holmes, Dennis, Vinante, Lorenzo, Bozza, Fernando, Pazos, Montserrat, Le Blanc-Onfroy, Magali, Gruber, Günther, Polkowski, Wojciech, Dedes, Konstantin J, Niewald, Marcus, Blohmer, Jens, McCready, David, Hoefer, Richard, Kelemen, Pond, Petralia, Gloria, Falzon, Mary, Joseph, David J, Tobias, Jeffrey S

“…To determine whether risk adapted intraoperative radiotherapy, delivered as a single dose during lumpectomy, can effectively replace postoperative whole breast…”
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Emerging therapeutic targets in endometrial cancer by Dedes, Konstantin J., Wetterskog, Daniel, Ashworth, Alan, Kaye, Stan B., Reis-Filho, Jorge S.

“…Advances in the understanding of the molecular pathology of the two types of endometrial carcinoma have underpinned the first steps in the development and…”
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Effect of MRE11 loss on PARP-inhibitor sensitivity in endometrial cancer in vitro by Koppensteiner, Romana, Samartzis, Eleftherios P, Noske, Aurelia, von Teichman, Adriana, Dedes, Ioannis, Gwerder, Myriam, Imesch, Patrick, Ikenberg, Kristian, Moch, Holger, Fink, Daniel, Stucki, Manuel, Dedes, Konstantin J

“…To evaluate the frequency of MRE11/RAD50/NBS1 (MRN)-complex loss of protein expression in endometrial cancers (EC) and to determine whether loss of MRE11…”
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Contrast Media–Enhanced Breast Computed Tomography With a Photon-Counting Detector: Initial Experiences on In Vivo Image Quality and Correlation to Histology by Berger, Nicole, Marcon, Magda, Wieler, Jann, Vorburger, Denise, Dedes, Konstantin J., Frauenfelder, Thomas, Varga, Zsuzsanna, Boss, Andreas

“…The aim of this study was to investigate the feasibility, the image quality, and the correlation with histology of dedicated spiral breast computed tomography…”
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Biomarker dynamics and prognosis in breast cancer after neoadjuvant chemotherapy by Zarotti, Cristina, Papassotiropoulos, Bärbel, Elfgen, Constanze, Dedes, Konstantin, Vorburger, Denise, Pestalozzi, Bernhard, Trojan, Andreas, Varga, Zsuzsanna

“…Breast cancer is a biologically diverse disease with treatment modalities selected based on tumor stage and tumor biology. Distinct intrinsic subtypes and…”
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Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition by Samartzis, Eleftherios P, Gutsche, Katrin, Dedes, Konstantin J, Fink, Daniel, Stucki, Manuel, Imesch, Patrick

“…ARID1A mutations are observed in various tumors, including ovarian clear cell (OCCC) and endometrioid carcinomas, endometrial, and breast carcinomas. They…”
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Anesthesia and Circulating Tumor Cells in Primary Breast Cancer Patients: A Randomized Controlled Trial by Hovaguimian, Frédérique, Braun, Julia, Z’graggen, Birgit Roth, Schläpfer, Martin, Dumrese, Claudia, Ewald, Christina, Dedes, Konstantin J., Fink, Daniel, Rölli, Urs, Seeberger, Manfred, Tausch, Christoph, Papassotiropoulos, Bärbel, Puhan, Milo A., Beck-Schimmer, Beatrice

“…BACKGROUND:The effect of anesthetic drugs on cancer outcomes remains unclear. This trial aimed to assess postoperative circulating tumor cell counts—an…”
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Anesthesia and Circulating Tumor Cells in Primary Breast Cancer Patients by Hovaguimian, Frédérique, Braun, Julia, Z'graggen, Birgit Roth, Schläpfer, Martin, Dumrese, Claudia, Ewald, Christina, Dedes, Konstantin J, Fink, Daniel, Rölli, Urs, Seeberger, Manfred, Tausch, Christoph, Papassotiropoulos, Bärbel, Puhan, Milo A, Beck-Schimmer, Beatrice

“…The effect of anesthetic drugs on cancer outcomes remains unclear. This trial aimed to assess postoperative circulating tumor cell counts-an independent…”
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Molecular and functional landscape of malignant serous effusions for precision oncology by Wegmann, Rebekka, Bankel, Lorenz, Festl, Yasmin, Lau, Kate, Lee, Sohyon, Arnold, Fabian, Cappelletti, Valentina, Fehr, Aaron, Picotti, Paola, Dedes, Konstantin J., Franzen, Daniel, Lenggenhager, Daniela, Bode, Peter K., Zoche, Martin, Moch, Holger, Britschgi, Christian, Snijder, Berend

“…Personalized treatment for patients with advanced solid tumors critically depends on the deep characterization of tumor cells from patient biopsies. Here, we…”
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A Cost-Effectiveness Analysis of Nivolumab versus Docetaxel for Advanced Nonsquamous NSCLC Including PD-L1 Testing by Matter-Walstra, Klazien, Schwenkglenks, Matthias, Aebi, Stefan, Dedes, Konstantin, Diebold, Joachim, Pietrini, Mario, Klingbiel, Dirk, von Moos, Roger, Gautschi, Oliver

“…Nivolumab (NIV) was recently approved in several countries for patients with pretreated advanced NSCLC. NIV is not cost-effective compared with docetaxel (DOC)…”
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Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations by Dedes, Konstantin J., Wilkerson, Paul M., Wetterskog, Daniel, Weigelt, Britta, Ashworth, Alan, Reis-Filho, Jorge S.

“…Utilizing the concept of synthetic lethality has provided new opportunities for the development of targeted therapies, by allowing the targeting of loss of…”
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Prepectoral implant-based breast reconstruction with TiLOOP® Bra Pocket – a single-centre retrospective study by Nguyen-Sträuli, Bich Doan, Vorburger, Denise, Frauchiger-Heuer, Heike, Bringolf, Lilian, Maggi, Nadia, Talimi-Schnabel, Julia, Dedes, Konstantin J.

“…Prepectoral implant-based reconstruction using synthetic meshes is feasible with good outcomes. We present our data using TiLOOP® Bra Pocket, a novel…”
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PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors by Dedes, Konstantin J, Wetterskog, Daniel, Mendes-Pereira, Ana M, Natrajan, Rachael, Lambros, Maryou B, Geyer, Felipe C, Vatcheva, Radost, Savage, Kay, Mackay, Alan, Lord, Christopher J, Ashworth, Alan, Reis-Filho, Jorge S

“…PTEN (phosphatase and tensin homolog) loss of function is the most common genetic aberration in endometrioid endometrial carcinomas. In addition to its…”
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Breast Cancer Assessment With Pulse-Echo Speed of Sound Ultrasound From Intrinsic Tissue Reflections: Proof-of-Concept by Ruby, Lisa, Sanabria, Sergio J, Martini, Katharina, Dedes, Konstantin J, Vorburger, Denise, Oezkan, Ece, Frauenfelder, Thomas, Goksel, Orcun, Rominger, Marga B

“…PURPOSEThe aim of this study was to differentiate malignant and benign solid breast lesions with a novel ultrasound (US) technique, which measures speed of…”
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A Micro CT Study in Patients with Breast Microcalcifications Using a Mathematical Algorithm to Assess 3D Structure by Kenkel, David, Varga, Zsuzsanna, Heuer, Heike, Dedes, Konstantin J, Berger, Nicole, Filli, Lukas, Boss, Andreas

“…The aim of this study was to evaluate the relevance of the three-dimensional (3D) structure of breast microcalcifications (MC) as a predictor of malignancy…”
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A multicenter phase II trial of anti-EGFR-immunoliposomes loaded with doxorubicin in patients with advanced triple negative breast cancer by Mamot, Christoph, Wicki, Andreas, Hasler-Strub, Ursula, Riniker, Salome, Li, Qiyu, Holer, Lisa, Bärtschi, Daniela, Zaman, Khalil, von Moos, Roger, Dedes, Konstantin J., Boos, Laura A., Novak, Urban, Bodmer, Alexandre, Ritschard, Reto, Obermann, Ellen C., Tzankov, Alexandar, Ackermann, Christoph, Membrez-Antonioli, Véronique, Zürrer-Härdi, Ursina, Caspar, Clemens B., Deuster, Stefanie, Senn, Martin, Winterhalder, Ralph, Rochlitz, Christoph

“…Advanced triple negative breast cancer (TNBC) is an aggressive, but initially chemo-sensitive disease. The prognosis is poor and more than three quarters of…”
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First ultrasound diagnosis of BI-RADS 3 lesions in young patients: can 6-months follow-up be sufficient to assess stability? by Marcon, Magda, Frauenfelder, Thomas, Becker, Anton S, Dedes, Konstantin, Boss, Andreas

“…Abstract Objectives To evaluate the outcome of repeated short-term follow-up with ultrasound in no high-risk young patients with a BI-RADS3 lesion at first…”
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Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer by Brandt, Simone, Samartzis, Eleftherios P, Zimmermann, Anne-Katrin, Fink, Daniel, Moch, Holger, Noske, Aurelia, Dedes, Konstantin J

“…BRCA1/2-deficient ovarian carcinomas are recognized as target for Poly (ADP-ribose) polymerase (PARP) inhibitors. BRCA1 and BRCA2 proteins are involved in…”
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Olaparib not cost-effective as maintenance therapy for platinum-sensitive, BRCA1/2 germline-mutated metastatic pancreatic cancer by Mehra, Tarun, Lupatsch, Judith E, Kössler, Thibaud, Dedes, Konstantin, Siebenhüner, Alexander Reinhard, von Moos, Roger, Wicki, Andreas, Schwenkglenks, Matthias E

“…To assess the cost-effectiveness and budget impact of olaparib as a maintenance therapy in platinum-responsive, metastatic pancreatic cancer patients harboring…”
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