Search Results - "Decsi, Balázs"
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High-Throughput Drug Stability Assessment via Biomimetic Metalloporphyrin-Catalyzed Reactions Using Laser-Assisted Rapid Evaporative Ionization Mass Spectrometry (LA-REIMS)
Published in Pharmaceutics (27-09-2024)“…Building extensive drug candidate libraries as early in the development pipeline as possible, with high-throughput in vitro absorption, distribution,…”
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Immobilization of human tyrosine hydroxylase onto magnetic nanoparticles – A novel formulation of a therapeutic enzyme
Published in International journal of biological macromolecules (01-05-2024)“…Human tyrosine hydroxylase (hTH) has key role in the production of catecholamine neurotransmitters. The structure, function and regulation of hTH has been…”
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3
Novel biomimetic nanocomposite for investigation of drug metabolism
Published in Journal of molecular liquids (15-12-2022)“…•A novel method for immobilization of metalloporphyrin (MP) in a nanocomposite system was developed.•Advanced nanocomposite combines the advantageous…”
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Combined Nanofibrous Face Mask: Co-Formulation of Lipases and Antibiotic Agent by Electrospinning Technique
Published in Pharmaceutics (01-04-2023)“…The application of enzyme-based therapies has received significant attention in modern drug development. Lipases are one of the most versatile enzymes that can…”
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Magnetically Agitated Nanoparticle-Based Batch Reactors for Biocatalysis with Immobilized Aspartate Ammonia-Lyase
Published in Catalysts (01-04-2021)“…In this study, we investigated the influence of different modes of magnetic mixing on effective enzyme activity of aspartate ammonia-lyase from Pseudomonas…”
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Effect of Binding Linkers on the Efficiency and Metabolite Profile of Biomimetic Reactions Catalyzed by Immobilized Metalloporphyrin
Published in Metabolites (01-12-2022)“…The investigation of liver-related metabolic stability of a drug candidate is a widely used key strategy in early-stage drug discovery. Metalloporphyrin-based…”
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Biomimetic Synthesis of Drug Metabolites in Batch and Continuous‐Flow Reactors
Published in Chemistry : a European journal (02-07-2018)“…A medium‐throughput screening (MTS) of biomimetic drug metabolite synthesis is developed by using an iron porphyrin catalyst. The microplate method, in…”
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Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor
Published in Micromachines (Basel) (01-10-2019)“…Biomimetic oxidation of drugs catalyzed by metalloporphyrins can be a novel and promising way for the effective and sustainable synthesis of drug metabolites…”
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Magnetic Nanoparticles with Dual Surface Functions-Efficient Carriers for Metalloporphyrin-Catalyzed Drug Metabolite Synthesis in Batch and Continuous-Flow Reactors
Published in Nanomaterials (Basel, Switzerland) (24-11-2020)“…The dual functionalization of magnetic nanoparticles with inert (methyl) and reactive (aminopropyl) groups enables efficient immobilization of synthetic…”
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Metalloporfirin-Alapú Biomimetikus Oxidálórendszerek Fejlesztése a Hordozórendszertől Az Alkalmazásig
Published 01-01-2023“…Az ideális gyógyszert jellemző tulajdonságokat a következőképpen lehet megfogalmazni: a szervezetbe juttatás után kifejti a kívánt farmakológiai hatást,…”
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Dissertation -
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Saliva-based microfluidic point-of-care diagnostic
Published in Theranostics (01-01-2023)“…There has been a long-standing interest in point-of-care (POC) diagnostics as a tool to improve patient care because it can provide rapid, actionable results…”
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Journal Article